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Journal Articles

Establishing contemporary benchmarks for Acute Myeloid Leukemia outcomes and measurable residual disease: Real-world data utilization from the ELN-david MRD international working group

Free
Gail Roboz, Tom Reuvekamp, Jacqueline Cloos, Malte Von Bonin, Francesco Buccisano, Lukas Haaksma, Maura Ikoma-Colturato, Joana Brioso Infante, Dennis Kim, Chrysavgi Lalayanni, David de Leeuw, Josephine Anne Lucero, Francesco Mannelli, Luca Maurillo, Federico Moretti, Josep F Nomdedeu Guinot, Apostolia Papalexandri, Guillermo Ramil López, Maximilian Röhnert, Christoph Röllig, Anderson João Simione, Daniela Späth, Felicitas R Thol, Anne Tierens, Adriano Venditti, Francois Vergez, Michael Heuser, Konstanze Döhner
Journal: Blood
Blood (2025) 146 (Supplement 1): 5183.
https://doi.org/10.1182/blood-2025-5183
Published: 2025
Journal Articles

Proteogenomic analysis of NPM1-mutated AML reveals clinical heterogeneity related to differentiation states and mitochondrial metabolism

Free
Sebastian Wolf, Josefine Jakob, Björn Häupl, Annika Meid, Daniela Späth, Felicitas R Thol, Hubert Serve, Konstanze Döhner, Hartmut Döhner, Thomas Oellerich
Journal: Blood
Blood (2025) 146 (Supplement 1): 660.
https://doi.org/10.1182/blood-2025-660
Published: 2025
Journal Articles

Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)

Free
Carmelo Gurnari, Tiziana Ottone, Alfonso Piciocchi, Daniela Späth, Annika Meid, Giovanni Marsili, Emiliano Fabiani, Francesca Romano, Maria Rosaria Pascale, Patrizia Chiusolo, Mauro Di Ianni, Marta Sobas, Lorenzo Brunetti, Guadalupe Oñate, Joana Brioso Infante, Jacopo Nanni, Calogero Vetro, Matilde Boada, Anna Candoni, Jorge Sierra, Nicola Potter, Amanda Gilkes, Sean Johnson, Ian Thomas, Brain Huntley, Nigel Russell, Richard Dillon, Hartmut Döhner, Konstanze Döhner, Maria Teresa Voso
Journal: Blood
Blood (2025) 146 (Supplement 1): 217.
https://doi.org/10.1182/blood-2025-217
Published: 2025
Journal Articles

The addition of a tyrosine kinase inhibitor to intensive chemotherapy significantly improves outcome in de novo BCR::ABL1+ acute myeloid leukemia treated with intensive chemotherapy

Free
Sarah Bertoli, Niklas Landberg, Emilie Bérard, Camille Gondran, Laetitia Largeaud, Véronique De Mas, Pierre-Yves Dumas, Arnaud Pigneux, Audrey Bidet, Sylvain Garciaz, Ludovic Gabellier, Gabrielle Roth-Guepin, Corentin Orvain, Pierre Peterlin, Rudy Birsen, Magda Alexis, Martin Carre, Emmanuelle Tavernier, Marion Boissard Simonet, Chantal Himberlin, Marc Maynadié, Kamel Laribi, Cécile Moluçon-Chabrot, Amine Belhabri, Samy Chraibi, Quentin Cabrera, Delphine Lebon, Emmanuel Raffoux, Thomas Cluzeau, Jean-Baptiste Micol, Mathieu Leclerc, Céline Berthon, Herve Dombret, Gunnar Juliusson, Anna Robelius, Sören Lehmann, Martin Jädersten, Lovisa Wennström, Pau Montesinos, Carmen Botella, Juan Miguel Bergua Burgues, Raimundo Garcia, Josefina Serrano, Mariluz Amigo, Patricia Garcia Ramirez, Claudia Sossa, Juan Manuel Alonso-Dominguez, Hartmut Döhner, Konstanze Döhner, Daniela Späth, Michael Kühn, Claudia Lengerke, Hans-Jörg Tischler, Christoph Röllig, Leo Ruhnke, Christian Thiede, Andreas Burchert, Hubert Serve, Carsten Mueller-Tidow, Claudia Baldus, Jurjen Versluis, Peter Valk, Daniel Kristensen, Anne Stidsholt Roug, Jiri Mayer, Mika Kontro, Pia Ettala, Vladimir Lazarevic, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 991.
https://doi.org/10.1182/blood-2025-991
Published: 2025
Journal Articles

Impact of Donor Type on Outcome after Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia Patients: Analysis of the German-Austrian Acute Myeloid Leukemia Study Group (AMLSG)

Free
Florian Kuchenbauer, MD PhD, Donald W. Bunjes, MD, Wolfgang Herr, MD, Michael Heuser, MD, Daniela Späth, MSc, Jochen Casper, MD, Heinz-August Horst, MD, Peter Brossart, MD, Gerhard Held, MD, Guido Kobbe, MD, Mark Ringhoffer, MD, Mohammed Wattad, MD, Helmut R Salih, MD, Katharina Götze, Gerald Wulf, MD, Matthias Theobald, MD PhD, Mathias J Rummel, MD, Walter Fiedler, MD, Jörg Westermann, MD PhD, Hans Salwender, MD, Andreas L. Petzer, MD, Frank Hartmann, MD, Michael Lübbert, Uwe Martens, MD, Richard Greil, MD, Hartmut H. Kirchner, MD, Peter Paschka, MD, Verena I. Gaidzik, MD, Veronica Teleanu, MD, Felicitas Thol, MD, Gudrun Göhring, PD, Konstanze Döhner, MD, Arnold Ganser, Hartmut Döhner, MD, Richard F. Schlenk, MD
Journal: Blood
Blood (2014) 124 (21): 1254.
https://doi.org/10.1182/blood.V124.21.1254.1254
Published: 2014
Journal Articles

Differential impact of allelic ratio and insertion site in FLT3 -ITD–positive AML with respect to allogeneic transplantation

Free
Clinical Trials & Observations
Richard F. Schlenk, Sabine Kayser, Lars Bullinger, Guido Kobbe, Jochen Casper, Mark Ringhoffer, Gerhard Held, Peter Brossart, Michael Lübbert, Helmut R. Salih, Thomas Kindler, Heinz A. Horst, Gerald Wulf, David Nachbaur, Katharina Götze, Alexander Lamparter, Peter Paschka, Verena I. Gaidzik, Veronica Teleanu, Daniela Späth, Axel Benner, Jürgen Krauter, Arnold Ganser, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2014) 124 (23): 3441–3449.
https://doi.org/10.1182/blood-2014-05-578070
Published: 2014
Includes: Supplemental data
Journal Articles

Impact Of The Pretreatment Characteristics As Well As Cyto- and Molecular-Genetic Profile On Outcome After Relapse In Acute Myeloid Leukemia

Free
Richard F. Schlenk, MD, Peter Frech, Sabine Kayser, MD, Daniela Späth, MSc, Peter Brossart, MD, Heinz-August Horst, MD, Doris M Kraemer, M.D., Gerhard Held, Mark Ringhoffer, MD, Alexander Burchardt, M.D., Andrea Kündgen, M.D., Katharina Goetze, MD, David Nachbaur, MD, Thomas Kindler, MD, Michael Lübbert, MD, Helmut R. Salih, MD, Hans Salwender, MD, Gerald Wulf, MD, Elisabeth Koller, MD, Mohammed Wattad, MD, Walter Fiedler, MD, Stephan Kremers, MD, Heinz Kirchen, MD, Bernd Hertenstein, MD, Peter Paschka, MD, Verena I. Gaidzik, MD, Veronica Teleanu, MD, Michael Heuser, MD, Felicitas Thol, MD, Arnold Ganser, MD, Konstanze Döhner, MD, Hartmut Döhner, MD
Journal: Blood
Blood (2013) 122 (21): 830.
https://doi.org/10.1182/blood.V122.21.830.830
Published: 2013
Journal Articles

Prospective Phase III Trial Of Valproic Acid (VPA) In Combination With All-Trans Retinoic Acid (ATRA) and Intensive Induction Therapy For AML In Older Patients: Final and Molecular Subset Analyses Of The AMLSG 06-04 Study

Free
Michela Giulia Tassara, MD, Konstanze Döhner, MD, Peter Brossart, MD, Gerhard Held, Katharina Goetze, MD, Heinz-August Horst, MD, Mark Ringhoffer, MD, Claus-Henning Kohne, MD, Stephan Kremers, MD, Aruna Raghavachar, MD, Gerald Wulf, MD, Heinz Kirchen, MD, David Nachbaur, MD, Hans-Günter Derigs, M.D., Mohammed Wattad, MD, Elisabeth Koller, MD, Wolfram Brugger, MD, Axel C. Matzdorff, MD, PhD, Richard Greil, MD, Gerhard Heil, MD, Daniela Späth, MSc, Peter Paschka, MD, Verena I. Gaidzik, MD, Martin Göttlicher, M.D., Hartmut Döhner, MD, Richard F. Schlenk, MD
Journal: Blood
Blood (2013) 122 (21): 3927.
https://doi.org/10.1182/blood.V122.21.3927.3927
Published: 2013
Journal Articles

Minimal Residual Disease (MRD) Monitoring in NPM1 Mutated Acute Myeloid Leukemia (AML): Impact of Concurrent FLT3 -ITD and DNMT3A Mutations on MRD Kinetics and Clinical Outcome

Free
Silke Kapp-Schwoerer, Jan Krönke, MD, Andrea Corbacioglu, PhD, Verena I. Gaidzik, MD, Peter Paschka, MD, Karina Eiwen, Daniela Späth, MSc, Gudrun Göhring, MD, Brigitte Schlegelberger, MD, PhD, Michael Lübbert, MD, Thomas Kindler, MD, Mohammed Wattad, MD, Ulrich Germing, MD, David Nachbaur, MD, Walter Fiedler, MD, Felicitas Thol, MD, Michael Heuser, MD, Jürgen Krauter, MD, Arnold Ganser, MD, Richard F. Schlenk, MD, Hartmut Döhner, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2013) 122 (21): 2555.
https://doi.org/10.1182/blood.V122.21.2555.2555
Published: 2013
Journal Articles

Treatment Results In Acute Myeloid Leukemia Over a Time Period Of 20 Years: Analysis Of The German-Austrian Acute Myeloid Leukemia Study Group (AMLSG)

Free
Richard F. Schlenk, MD, Konstanze Döhner, MD, Michael Heuser, MD, Daniela Späth, MSc, Carina Morlok, Alexander Lamparter, Klaus-Henning Koehne, M.D., Heinz-August Horst, MD, Peter Brossart, MD, Gerhard Held, Andrea Kündgen, M.D., Mark Ringhoffer, MD, Mohammed Wattad, MD, Helmut R. Salih, MD, Katharina S. Goetze, MD, Gerald Wulf, MD, Matthias Theobald, MD, PhD, Mathias J. Rummel, MD, Walter Fiedler, MD, Jörg Westermann, MD, Hans Salwender, MD, Andreas L. Petzer, MD, Frank Hartmann, MD, Michael Lübbert, MD, Uwe M. Martens, MD, Richard Greil, MD, Hartmut Kirchner, MD, Peter Paschka, MD, Verena I. Gaidzik, MD, Sabine Kayser, MD, Veronica Teleanu, MD, Felicitas Thol, MD, Gudrun Göhring, MD, Arnold Ganser, MD, Hartmut Döhner, MD
Journal: Blood
Blood (2013) 122 (21): 3878.
https://doi.org/10.1182/blood.V122.21.3878.3878
Published: 2013
Journal Articles

Clinical Impact of GATA2 Mutations in Acute Myeloid Leukemia Patients Harboring CEBPA Mutations: A Study of the AML Study Group (AMLSG)

Free
Frauke Theis, Andrea Corbacioglu, PhD, Verena I. Gaidzik, MD, Peter Paschka, MD, Daniela Späth, MSc, Michaela Rehrl, Lars Bullinger, MD, PhD, Brigitte Schlegelberger, MD, PhD, Gudrun Göhring, MD, Claus-Henning Köhne, MD, Ulrich Germing, MD, Peter Brossart, MD, Heinz-August Horst, MD, Detlef Haase, MD, Katharina S. Götze, MD, Mark Ringhoffer, MD, Walter Fiedler, MD, David Nachbaur, MD, Thomas Kindler, MD, Gerhard Held, Michael Lübbert, MD, Mohammed Wattad, MD, Helmut R. Salih, MD, Jürgen Krauter, MD, Michael Heuser, MD, Arnold Ganser, MD, Hartmut Döhner, MD, Richard F. Schlenk, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2013) 122 (21): 1332.
https://doi.org/10.1182/blood.V122.21.1332.1332
Published: 2013
Journal Articles

Clonal evolution in relapsed NPM1 -mutated acute myeloid leukemia

Free
Jan Krönke, Lars Bullinger, Veronica Teleanu, Florian Tschürtz, Verena I. Gaidzik, Michael W. M. Kühn, Frank G. Rücker, Karlheinz Holzmann, Peter Paschka, Silke Kapp-Schwörer, Daniela Späth, Thomas Kindler, Marcus Schittenhelm, Jürgen Krauter, Arnold Ganser, Gudrun Göhring, Brigitte Schlegelberger, Richard F. Schlenk, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2013) 122 (1): 100–108.
https://doi.org/10.1182/blood-2013-01-479188
Published: 2013
Includes: Supplemental data
Journal Articles

Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG)

Free
Verena I. Gaidzik, Richard F. Schlenk, Peter Paschka, Anja Stölzle, Daniela Späth, Andrea Kuendgen, Marie von Lilienfeld-Toal, Wolfram Brugger, Hans Günter Derigs, Stephan Kremers, Richard Greil, Aruna Raghavachar, Mark Ringhoffer, Helmut R. Salih, Mohammed Wattad, Heinz G. Kirchen, Volker Runde, Gerhard Heil, Andreas L. Petzer, Michael Girschikofsky, Michael Heuser, Sabine Kayser, Gudrun Goehring, Maria-Veronica Teleanu, Brigitte Schlegelberger, Arnold Ganser, Jürgen Krauter, Lars Bullinger, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2013) 121 (23): 4769–4777.
https://doi.org/10.1182/blood-2012-10-461624
Published: 2013
Includes: Supplemental data
Journal Articles

Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG)

Free
Peter Paschka, Juan Du, Richard F. Schlenk, Verena I. Gaidzik, Lars Bullinger, Andrea Corbacioglu, Daniela Späth, Sabine Kayser, Brigitte Schlegelberger, Jürgen Krauter, Arnold Ganser, Claus-Henning Köhne, Gerhard Held, Marie von Lilienfeld-Toal, Heinz Kirchen, Mathias Rummel, Katharina Götze, Heinz-August Horst, Mark Ringhoffer, Michael Lübbert, Mohammed Wattad, Helmut R. Salih, Andrea Kündgen, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2013) 121 (1): 170–177.
https://doi.org/10.1182/blood-2012-05-431486
Published: 2013
Includes: Supplemental data
Journal Articles

Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies

Free
Clinical Trials & Observations
Sabine Kayser, Manuela Zucknick, Konstanze Döhner, Jürgen Krauter, Claus-Henning Köhne, Heinz A. Horst, Gerhard Held, Marie von Lilienfeld-Toal, Sibylla Wilhelm, Mathias Rummel, Ulrich Germing, Katharina Götze, David Nachbaur, Brigitte Schlegelberger, Gudrun Göhring, Daniela Späth, Carina Morlok, Veronica Teleanu, Arnold Ganser, Hartmut Döhner, Richard F. Schlenk, for the German-Austrian AML Study Group
Journal: Blood
Blood (2012) 119 (2): 551–558.
https://doi.org/10.1182/blood-2011-07-367508
Published: 2012
Includes: Supplemental data
Journal Articles

The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML

Free
Clinical Trials & Observations
Sabine Kayser, Konstanze Döhner, Jürgen Krauter, Claus-Henning Köhne, Heinz A. Horst, Gerhard Held, Marie von Lilienfeld-Toal, Sibylla Wilhelm, Andrea Kündgen, Katharina Götze, Mathias Rummel, David Nachbaur, Brigitte Schlegelberger, Gudrun Göhring, Daniela Späth, Carina Morlok, Manuela Zucknick, Arnold Ganser, Hartmut Döhner, Richard F. Schlenk, for the German-Austrian AMLSG
Journal: Blood
Blood (2011) 117 (7): 2137–2145.
https://doi.org/10.1182/blood-2010-08-301713
Published: 2011
Includes: Supplemental data
Journal Articles

Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome

Free
Clinical Trials & Observations
Sabine Kayser, Richard F. Schlenk, Martina Correa Londono, Frank Breitenbuecher, Kerstin Wittke, Juan Du, Silja Groner, Daniela Späth, Jürgen Krauter, Arnold Ganser, Hartmut Döhner, Thomas Fischer, Konstanze Döhner, for the German-Austrian AML Study Group (AMLSG)
Journal: Blood
Blood (2009) 114 (12): 2386–2392.
https://doi.org/10.1182/blood-2009-03-209999
Published: 2009
Journal Articles

Clinical Impact of WT1 Mutations in the Context of Other Molecular Markers in Cytogenetically Normal Acute Myeloid Leukemia (AML): A Study of the German-Austrian AML Study Group (AMLSG).

Free
Verena I. Gaidzik, MD, Marianne Habdank, Simone Moschny, Silja Groner, Daniela Spath, Jurgen Krauter, MD, Brigitte Schlegelberger, MD, Arnold Ganser, MD, Hartmut Dohner, MD, Richard F. Schlenk, Konstanze Dohner, MD
Journal: Blood
Blood (2007) 110 (11): 364.
https://doi.org/10.1182/blood.V110.11.364.364
Published: 2007