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Maureen M. O’Brien
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Journal Articles

DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia

Carolin S. Escherich, Takaya Moriyama, Zhenhua Li, Yu-Chih Hsiao, Wenjian Yang, Yizhen Li, Noemi Reyes, Megan Walker, Amit Budhraja, Sheetal Bhatara, Ernesto Diaz-Flores, Wendy Stock, Elisabeth Paietta, Marina Y. Konopleva, Steven M. Kornblau, Mark R. Litzow, Hiroto Inaba, Ching-Hon Pui, Joseph T. Opferman, Mignon L. Loh, Jiyang Yu, Maureen M. O’Brien, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2025) 145 (11): 1182–1194.
https://doi.org/10.1182/blood.2024026085
Published: 2025
Includes: Supplemental data
Journal Articles

PEPN2312: A Pediatric Early Phase Clinical Trials Network (PEP-CTN) Phase 1 Trial of Imetelstat with Fludarabine/Cytarabine in Pediatric Patients with Relapsed/Refractory AML, MDS, or JMML

Alexandra McLean Stevens, Maureen M. O'Brien, Xiaowei Liu, Charles G Minard, Olga Militano, Joel M Reid, Shyamala Navada, Todd M Cooper, Sarah K. Tasian, Elizabeth Fox, Brenda J. Weigel
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.4.
https://doi.org/10.1182/blood-2024-207907
Published: 2024
Journal Articles

A Children's Oncology Group Clinical Trial of Long-Term Outcomes in Survivors of Down Syndrome-Associated Acute Leukemia (ALTE22C1): Clinical Trial in Progress

Maria Monica Gramatges, Lauren N Sanclemente, Lacey Hall, Danielle L Mitchell, Olga A Taylor, Tanya Shannon, Tyler Brown, Michelle M Nuño, Smita Bhatia, Eric J. Chow, Kelly D. Getz, Johann K. Hitzler, Amanda M Li, Kaitlin McCloskey, Paul C Nathan, Maureen M. O'Brien, Serina Patel, Anupam Verma, Angela R Yarbrough, Geraldine Aubert, Tracie C Rosser, Lisa M Jacola, Philip J Lupo, Karen R Rabin
Journal: Blood
Blood (2024) 144 (Supplement 1): 2808.1.
https://doi.org/10.1182/blood-2024-203724
Published: 2024
Journal Articles

Blinatumomab Added to Chemotherapy Improves Disease-Free Survival in Newly Diagnosed NCI Standard Risk Pediatric B-Acute Lymphoblastic Leukemia: Results from the Randomized Children's Oncology Group Study AALL1731

Rachel E. Rau, Sumit Gupta, John A. Kairalla, Karen R Rabin, Anne Angiolillo, Cindy Wang, Andrew J. Carroll, Susan Conway, Meenakshi Devidas, Lia Gore, Ilan R. Kirsch, Holly R. Kubaney, Amanda M Li, Jennifer L. McNeer, Olga Militano, Yvonne Moyer, Maureen M. O'Brien, Maki Okada, Shalini C. Reshmi, Mary Shago, Elizabeth R. Wagner, Naomi J. Winick, Brent L. Wood, Faraz Zaman, Gerhard Zugmaier, Sue Zupanec, Stephen P. Hunger, David T. Teachey, Elizabeth A. Raetz, Mignon L. Loh
Journal: Blood
Blood (2024) 144 (Supplement 1): 1.
https://doi.org/10.1182/blood-2024-207450
Published: 2024
Journal Articles

TCL1A Is Associated with Blinatumomab Response and Immune Activation in Pediatric B-ALL

Andrew Hughes, Rawan Shraim, Lahari Uppuluri, Haley Newman, Gongping Shi, Julie Asare, Theresa Ryan, Elizabeth A. Raetz, James A. Whitlock, Maureen M. O'Brien, Deepa Bhojwani, Rachel E. Rau, Kara L. Davis, Stacy Cooper, Patrick Brown, Stephen P. Hunger, Mignon L. Loh, Laura E. Hogan, Stephan A. Grupp, Jun J. Yang, David T. Teachey, Caroline Diorio
Journal: Blood
Blood (2024) 144 (Supplement 1): 634.
https://doi.org/10.1182/blood-2024-203756
Published: 2024
Journal Articles

A Retrospective Study of Inotuzumab Ozogamicin in Individuals with Down Syndrome and B-Cell Acute Lymphoblastic Leukemia

Amanda M Li, Catherine Aftandilian, Susan Colace, Sarah Fanizzi, Kelly Elizabeth Faulk, Erin M. Guest, Ammar Hayani, Richard Ho, Anjali Khanna, Kasey Leger, David McCall, Tamara P. Miller, Holly Pacenta, Troy Quigg, Jeremy D. Rubinstein, Deepa Bhojwani, Susan R Rheingold, Maureen M. O'Brien, Karen R Rabin
Journal: Blood
Blood (2024) 144 (Supplement 1): 4204.
https://doi.org/10.1182/blood-2024-209455
Published: 2024
Journal Articles

Understanding the Associations between High-Dose Methotrexate Pharmacokinetics and the Risk of Adverse Events in Children and Adolescents with Down Syndrome Associated High-Risk Acute Lymphoblastic Leukemia

Kate D. Westmoreland, Zachary L Taylor, Tamara P. Miller, Ashley Chavana, Karen R Rabin, Austin L Brown, Melanie Brooke Bernhardt, Eric S. Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey
Journal: Blood
Blood (2024) 144 (Supplement 1): 1438.
https://doi.org/10.1182/blood-2024-211870
Published: 2024
Journal Articles

APAL2020SC Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias

Michele S. Redell, Todd A. Alonzo, Robert Gerbing, Jim Wang, Maureen M. O'Brien, Gwen Nichols, Laura Di Laurenzio, Sarah K. Tasian, C. Michel Zwaan, Dirk Reinhardt, E. Anders Kolb, Todd Cooper
Journal: Blood
Blood (2023) 142 (Supplement 1): 1492.
https://doi.org/10.1182/blood-2023-190947
Published: 2023
Journal Articles

Impact of Treatment with Inotuzumab Ozogamicin before or after Chimeric Antigen Receptor T-Cell Therapy in Children with Relapsed/Refractory Acute Lymphoblastic Leukemia

Susan R Rheingold, Lingyun Ji, Lia Gore, Xinxin Xu, Deepa Bhojwani, Nirali N. Shah, Elizabeth A. Raetz, Mignon L. Loh, Maureen M. O'Brien
Journal: Blood
Blood (2023) 142 (Supplement 1): 2876.
https://doi.org/10.1182/blood-2023-183103
Published: 2023
Journal Articles

Severe Adverse Events Associated with Concentrations of High Dose Methotrexate in Pediatric Acute Lymphoblastic Leukemia Patients

Tamara P. Miller, Nicholas P. DeGroote, Zachary Taylor, Lauren Pommert, Oluwafunbi Awoniyi, Sarah Board, Ngozi Ugboh, Vivek Joshi, Allison Weisnicht, Nicholas Ambrosino, Melanie Brooke Bernhardt, Eric S Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey
Journal: Blood
Blood (2022) 140 (Supplement 1): 2185–2186.
https://doi.org/10.1182/blood-2022-169741
Published: 2022
Journal Articles

Potential Impact of Treatment with Inotuzumab Ozogamicin on Chimeric Antigen Receptor T-Cell Therapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia

Valeria Ceolin, Erica Brivio, Susan R. Rheingold, Allison Barz Leahy, Britta Julia Vormoor, Maureen M. O'Brien, Jeremy Rubinstein, Krzysztof Kalwak, Barbara De Moerloose, Elad Jacoby, Peter Bader, José L. Fuster, Franco Locatelli, Peter Hoogerbrugge, Friso Calkoen, Christian M. Zwaan
Journal: Blood
Blood (2021) 138 (Supplement 1): 3824.
https://doi.org/10.1182/blood-2021-146556
Published: 2021
Journal Articles

Phase 1b Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Michael J. Burke, David S. Ziegler, Francisco Bautista, Andishe Attarbaschi, Lia Gore, Franco Locatelli, Maureen M. O'Brien, Melinda Pauly, Mihaela Obreja, Christopher L. Morris, Andre Baruchel
Journal: Blood
Blood (2021) 138 (Supplement 1): 1235.
https://doi.org/10.1182/blood-2021-147588
Published: 2021
Journal Articles

Comparison of Severe Toxicities Following High Dose Methotrexate Administration By Demographics and over Time in Pediatric Patients with Acute Lymphoblastic Leukemia

Tamara P. Miller, Nicholas P. DeGroote, Lauren Pommert, Oluwafunbi Awoniyi, Sarah Board, Ngozi Ugboh, Vivek Joshi, Nicholas Ambrosino, Allison Weisnicht, Heidi Hsiao, Melanie Brooke Bernhardt, Eric S Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey
Journal: Blood
Blood (2021) 138 (Supplement 1): 1970.
https://doi.org/10.1182/blood-2021-151081
Published: 2021
Journal Articles

Phase 2 Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory (R/R) Acute Lymphoblastic Leukemia (ALL)

David S. Ziegler, Van Huynh, Michael J. Burke, Lia Gore, Franco Locatelli, Maureen M. O'Brien, Christopher Kim, Mihaela Obreja, Christopher L. Morris, André Baruchel
Journal: Blood
Blood (2021) 138 (Supplement 1): 4403.
https://doi.org/10.1182/blood-2021-153865
Published: 2021
Journal Articles

A Phase 3 Randomized Trial of Inotuzumab Ozogamicin for Newly Diagnosed High-Risk B-ALL: Safety Phase Results from Children's Oncology Group Protocol AALL1732

Jennifer L. McNeer, Maureen M. O'Brien, Susan R. Rheingold, Meenakshi Devidas, Zhiguo Chen, Deepa Bhojwani, Anurag K. Agrawal, Brent Wood, Eugene Suh, Sarah Alexander, Tamara P. Miller, Olga Militano, Elizabeth A. Raetz, Mignon L. Loh
Journal: Blood
Blood (2021) 138 (Supplement 1): 3398.
https://doi.org/10.1182/blood-2021-149478
Published: 2021
Journal Articles

CD22 low /Bcl-2 high Expression Identifies Poor Response to Inotuzumab in Relapsed/ Refractory Acute Lymphoblastic Leukemia

Ernesto Diaz-Flores, Astrid Wintering, Kenichi Ishiyama, Stanley Tamaki, Courtney Tamaki, Josh Fandel, Lingyun Ji, Brent Wood, Constance M. Yuan, Nirali N. Shah, Maureen M. O'Brien, Mignon L. Loh
Journal: Blood
Blood (2021) 138 (Supplement 1): 614.
https://doi.org/10.1182/blood-2021-149037
Published: 2021
Journal Articles

Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia Harboring Heterogeneous Genomic Profiles Respond to Venetoclax in Combination with Chemotherapy

Andrew E. Place, MDPhD, Seth E. Karol, MD, Christopher J. Forlenza, MD, Marion Gambart, MD, Todd M. Cooper, DO, Christopher Fraser, MBBS, Gunnar Cario, MD PhD, Maureen M O'Brien, MD, Nicolas U. Gerber, MD, Phillip Barnette, MD, Dirk Reinhardt, MDPhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Mignon L. Loh, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-137376
Published: 2020
Journal Articles

A Phase 2 Trial of Inotuzumab Ozogamicin (InO) in Children and Young Adults with Relapsed or Refractory (R/R) CD22+ B-Acute Lymphoblastic Leukemia (B-ALL): Results from Children's Oncology Group Protocol AALL1621

Maureen M O'Brien, MD, Lingyun Ji, PhD, Nirali N. Shah, MD, Susan R. Rheingold, MD, Deepa Bhojwani, MD, Joanna S. Yi, MD, Constance M. Yuan, MD PhD, Andrew C Harris, MD, Patrick A. Brown, MD, Michael J. Borowitz, MD PhD, Olga Militano, PharmD, Meenakshi Devidas, PhD, Elizabeth A. Raetz, MD, Lia Gore, MD, Mignon L. Loh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 741.
https://doi.org/10.1182/blood-2019-128977
Published: 2019
Journal Articles

V2 Trial: A Phase I Study of Venetoclax Combined with CPX-351 for Children, Adolescents and Young Adults with Relapsed or Refractory Acute Leukemia

Laura Agresta, MD, Maureen M O'Brien, MD, Kana Mizuno, PhD, Robin Norris, MD MS, MPH, Erin H. Breese, MD PhD, Christine L Phillips, MD, Karen Burns, MD, Benjamin Mizukawa, Lynn Lee, MD, Adam Lane, PhD, Robert B. Lorsbach, MD PhD, Thomas D. Ryan, MD PhD, Pankaj B. Desai, PhD, Alexander A. Vinks, PharmD, PhD, H. Leighton Grimes, PhD, John P Perentesis, Michael J. Absalon, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3830.
https://doi.org/10.1182/blood-2019-121514
Published: 2019
Journal Articles

Phase 1b Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Michael J. Burke, MD, David S. Ziegler, MBBS, FRACP, MD, Francisco José Bautista Sirvent, MD PhD, Andishe Attarbaschi, MD, Lia Gore, MD, Franco Locatelli, MD PhD, Maureen M O'Brien, MD, Melinda Pauly, MD, Mihaela Obreja, PhD, Christopher L. Morris, PhDMD, Andre Baruchel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3873.
https://doi.org/10.1182/blood-2019-127350
Published: 2019