Ursula Creutzig,on behalf of the AML Committee of the International BFM Study Group,Marry M. van den Heuvel-Eibrink,on behalf of the AML Committee of the International BFM Study Group,Brenda Gibson,on behalf of the AML Committee of the International BFM Study Group,Michael N. Dworzak,on behalf of the AML Committee of the International BFM Study Group,Souichi Adachi,on behalf of the AML Committee of the International BFM Study Group,Eveline de Bont,on behalf of the AML Committee of the International BFM Study Group,Jochen Harbott,on behalf of the AML Committee of the International BFM Study Group,Henrik Hasle,on behalf of the AML Committee of the International BFM Study Group,Donna Johnston,on behalf of the AML Committee of the International BFM Study Group,Akitoshi Kinoshita,on behalf of the AML Committee of the International BFM Study Group,Thomas Lehrnbecher,on behalf of the AML Committee of the International BFM Study Group,Guy Leverger,on behalf of the AML Committee of the International BFM Study Group,Ester Mejstrikova,on behalf of the AML Committee of the International BFM Study Group,Soheil Meshinchi,on behalf of the AML Committee of the International BFM Study Group,Andrea Pession,on behalf of the AML Committee of the International BFM Study Group,Susana C. Raimondi,on behalf of the AML Committee of the International BFM Study Group,Lillian Sung,on behalf of the AML Committee of the International BFM Study Group,Jan Stary,on behalf of the AML Committee of the International BFM Study Group,Christian M. Zwaan,on behalf of the AML Committee of the International BFM Study Group,Gertjan J. L. Kaspers,on behalf of the AML Committee of the International BFM Study Group,Dirk Reinhardt,on behalf of the AML Committee of the International BFM Study Group

View Articletitled, Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel

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How I Treat

How I treat amyloidosis: the importance of accurate diagnosis and amyloid typing

Nelson Leung,Samih H. Nasr,Sanjeev Sethi

View Articletitled, How I treat amyloidosis: the importance of accurate diagnosis and amyloid typing

Clinical Trials and Observations

Clinical and prognostic implications of low or high level of von Willebrand factor in patients with Waldenström macroglobulinemia
Clinical Trials & Observations

Benedicte Hivert,Claudine Caron,Stephanie Petit,Cecile Charpy,Corinne Fankam-Siaka,Stephanie Lecocq,Christophe Zawadzki,Sophie Susen,Manuela Rusu,Alain Duhamel,Olivier Tournilhac,Jenny Goudemand,Pierre Morel

View Articletitled, Clinical and prognostic implications of low or high level of von Willebrand factor in patients with Waldenström macroglobulinemia

Supplemental data

Final results of a multicenter trial addressing role of CSF flow cytometric analysis in NHL patients at high risk for CNS dissemination
Clinical Trials & Observations

Giulia Benevolo,on behalf of the Fondazione Italiana Linfomi,Alessandra Stacchini,on behalf of the Fondazione Italiana Linfomi,Michele Spina,on behalf of the Fondazione Italiana Linfomi,Andrés J. M. Ferreri,on behalf of the Fondazione Italiana Linfomi,Marcella Arras,on behalf of the Fondazione Italiana Linfomi,Laura Bellio,on behalf of the Fondazione Italiana Linfomi,Barbara Botto,on behalf of the Fondazione Italiana Linfomi,Pietro Bulian,on behalf of the Fondazione Italiana Linfomi,Maria Cantonetti,on behalf of the Fondazione Italiana Linfomi,Lorella Depaoli,on behalf of the Fondazione Italiana Linfomi,Nicola Di Renzo,on behalf of the Fondazione Italiana Linfomi,Alice Di Rocco,on behalf of the Fondazione Italiana Linfomi,Andrea Evangelista,on behalf of the Fondazione Italiana Linfomi,Silvia Franceschetti,on behalf of the Fondazione Italiana Linfomi,Laura Godio,on behalf of the Fondazione Italiana Linfomi,Francesco Mannelli,on behalf of the Fondazione Italiana Linfomi,Vincenzo Pavone,on behalf of the Fondazione Italiana Linfomi,Pietro Pioltelli,on behalf of the Fondazione Italiana Linfomi,Umberto Vitolo,on behalf of the Fondazione Italiana Linfomi,Enrico M. Pogliani,on behalf of the Fondazione Italiana Linfomi

View Articletitled, Final results of a multicenter trial addressing role of CSF flow cytometric analysis in NHL patients at high risk for CNS dissemination

Hematopoiesis and Stem Cells

Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age

Jonathan Kenyon,Pingfu Fu,Karen Lingas,Emily Thomas,Anshul Saurastri,Gabriela Santos Guasch,David Wald,Stanton L. Gerson

View Articletitled, Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age

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Immunobiology

Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8⁺ T cells

Corey Smith,Diah Elhassen,Stephanie Gras,Katherine K. Wynn,Vijayendra Dasari,Judy Tellam,Siok-Keen Tey,Sweera Rehan,Yu Chih Liu,Jamie Rossjohn,Scott R. Burrows,Rajiv Khanna

View Articletitled, Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells

Endogenous HLA class II epitopes that are immunogenic in vivo show distinct behavior toward HLA-DM and its natural inhibitor HLA-DO

Anita N. Kremer,Edith D. van der Meijden,Maria W. Honders,Jelle J. Goeman,Emmanuel J. H. J. Wiertz,J. H. Frederik Falkenburg,Marieke Griffioen

View Articletitled, Endogenous HLA class II epitopes that are immunogenic in vivo show distinct behavior toward HLA-DM and its natural inhibitor HLA-DO

Supplemental data

Regulation of plasmacytoid dendritic cell responses by PIR-B
Brief Report

Yoshiya Mitsuhashi,Akira Nakamura,Shota Endo,Kazuya Takeda,Toshiki Yabe-Wada,Toshihiro Nukiwa,Toshiyuki Takai

View Articletitled, Regulation of plasmacytoid dendritic cell responses by PIR-B

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Lymphoid Neoplasia

Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma

Deborah J. Kuhn,Zuzana Berkova,Richard J. Jones,Richard Woessner,Chad C. Bjorklund,Wencai Ma,R. Eric Davis,Pei Lin,Hua Wang,Timothy L. Madden,Caimiao Wei,Veerabhadran Baladandayuthapani,Michael Wang,Sheeba K. Thomas,Jatin J. Shah,Donna M. Weber,Robert Z. Orlowski

View Articletitled, Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma

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Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells

Marta Coscia,Candida Vitale,Silvia Peola,Myriam Foglietta,Micol Rigoni,Valentina Griggio,Barbara Castella,Daniela Angelini,Sabina Chiaretti,Chiara Riganti,Anna Guarini,Daniela Drandi,Marco Ladetto,Amalia Bosia,Robin Foà,Luca Battistini,Mario Boccadoro,Jean-Jacques Fournié,Massimo Massaia

View Articletitled, Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells

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Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial

King L. Tan,David W. Scott,Fangxin Hong,Brad S. Kahl,Richard I. Fisher,Nancy L. Bartlett,Ranjana H. Advani,Rena Buckstein,Lisa M. Rimsza,Joseph M. Connors,Christian Steidl,Leo I. Gordon,Sandra J. Horning,Randy D. Gascoyne

View Articletitled, Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial

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Transcriptome sequencing in Sézary syndrome identifies Sézary cell and mycosis fungoides-associated lncRNAs and novel transcripts

Carolyn S. Lee,Alexander Ungewickell,Aparna Bhaduri,Kun Qu,Dan E. Webster,Randall Armstrong,Wen-Kai Weng,Cody J. Aros,Angela Mah,Richard O. Chen,Meihong Lin,Uma Sundram,Howard Y. Chang,Markus Kretz,Youn H. Kim,Paul A. Khavari

View Articletitled, Transcriptome sequencing in Sézary syndrome identifies Sézary cell and mycosis fungoides-associated lncRNAs and novel transcripts

Supplemental data

Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL

Sandrine Le Noir,Raouf Ben Abdelali,Marc Lelorch,Julie Bergeron,Stephanie Sungalee,Dominique Payet-Bornet,Patrick Villarèse,Arnaud Petit,Céline Callens,Ludovic Lhermitte,Laurence Baranger,Isabelle Radford-Weiss,Marie-José Grégoire,Hervé Dombret,Norbert Ifrah,Salvatore Spicuglia,Serge Romana,Jean Soulier,Bertrand Nadel,Elizabeth Macintyre,Vahid Asnafi

View Articletitled, Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL

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Myeloid Neoplasia

Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3

De-Chen Lin,Tong Yin,Maya Koren-Michowitz,Ling-Wen Ding,Saskia Gueller,Sigal Gery,Takayuki Tabayashi,Ulla Bergholz,Julhash U. Kazi,Lars Rönnstrand,Carol Stocking,H. Phillip Koeffler

View Articletitled, Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3

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Platelets and Thrombopoiesis

Defective regulatory B-cell compartment in patients with immune thrombocytopenia

Xiaojuan Li,Hui Zhong,Weili Bao,Nayla Boulad,Jessie Evangelista,Muhammad Anis Haider,James Bussel,Karina Yazdanbakhsh

View Articletitled, Defective regulatory B-cell compartment in patients with immune thrombocytopenia

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CD16⁺ monocytes control T-cell subset development in immune thrombocytopenia

Hui Zhong,Weili Bao,Xiaojuan Li,Allison Miller,Caroline Seery,Naznin Haq,James Bussel,Karina Yazdanbakhsh

View Articletitled, CD16+ monocytes control T-cell subset development in immune thrombocytopenia

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Red Cells, Iron, and Erythropoiesis

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis

Anu Laitala,Ellinoora Aro,Gail Walkinshaw,Joni M. Mäki,Maarit Rossi,Minna Heikkilä,Eeva-Riitta Savolainen,Michael Arend,Kari I. Kivirikko,Peppi Koivunen,Johanna Myllyharju

View Articletitled, Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis

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Thrombosis and Hemostasis

Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes

Krystin Krauel,Claudia Weber,Sven Brandt,Ulrich Zähringer,Uwe Mamat,Andreas Greinacher,Sven Hammerschmidt

View Articletitled, Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes

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Transplantation

Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation

Régis Peffault de Latour,Rodrigo T. Calado,Marc Busson,Jeffrey Abrams,Nadir Adoui,Marie Robin,Jérôme Larghero,Nathalie Dhedin,Alienor Xhaard,Emmanuel Clave,Dominique Charron,Antoine Toubert,Pascale Loiseau,Gérard Socié,Neal S. Young

View Articletitled, Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation

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Vascular Biology

Autoantibodies specific to a peptide of β₂-glycoprotein I cross-react with TLR4, inducing a proinflammatory phenotype in endothelial cells and monocytes

Tania Colasanti,Cristiano Alessandri,Antonella Capozzi,Maurizio Sorice,Federica Delunardo,Agostina Longo,Marina Pierdominici,Fabrizio Conti,Simona Truglia,Alessandra Siracusano,Guido Valesini,Elena Ortona,Paola Margutti

View Articletitled, Autoantibodies specific to a peptide of β2-glycoprotein I cross-react with TLR4, inducing a proinflammatory phenotype in endothelial cells and monocytes

Supplemental data

Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1–induced collective directional migration and angiogenic sprouting

Malika Oubaha,Michelle I. Lin,Yoran Margaron,Dominic Filion,Emily N. Price,Leonard I. Zon,Jean-François Côté,Jean-Philippe Gratton

View Articletitled, Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1–induced collective directional migration and angiogenic sprouting

Supplemental data

Correspondence

Characteristics and outcomes of patients with V299L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors

Elias Jabbour,Van Morris,Hagop Kantarjian,Cameron C. Yin,Elizabeth Burton,Jorge Cortes

View Articletitled, Characteristics and outcomes of patients with V299L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors

Prognostic implications of cumulative dosing in total therapy 3

Bart Barlogie,John Crowley

View Articletitled, Prognostic implications of cumulative dosing in total therapy 3

Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40^phox in humans but not in mice

Juhi Bagaitkar,Juan D. Matute,Anthony Austin,Andres A. Arias,Mary C. Dinauer

View Articletitled, Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40phox in humans but not in mice

Cover Image

Cover Image

The authors investigate the functional consequences of SF3B1 haploinsufficiency in myelodysplastic syndromes. The SF3B1 gene is commonly mutated in refractory anemia with ring sideroblasts, and encodes a protein involved in RNA splicing. Meayamycin, a SF3b splicing inhibitor, induces formation of ringed sideroblasts when added to cultured bone marrow cells from healthy individuals. Cover art by Dr Heesun J. Rogers and Edy Hasrouni. See the article by Visconte et al on page 3173.
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