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Lymphocytosis and ibrutinib treatment of CLL
Changing myelofibrosis’s natural course at last
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy
Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug
Pomalidomide alone or in combination with low-dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study
Impact of ruxolitinib on the natural history of primary myelofibrosis: a comparison of the DIPSS and the COMFORT-2 cohorts
SET-NUP214 is a recurrent γδ lineage-specific fusion transcript associated with corticosteroid/chemotherapy resistance in adult T-ALL
Contribution of cerebrospinal fluid sCD19 levels to the detection of CNS lymphoma and its impact on disease outcome
Tracing the development of acute myeloid leukemia in CBL syndrome
The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT platelets in patients with primary platelet function defects
Issue Archive
March 20 2014
In this Issue
Table of Contents
INSIDE BLOOD
CLINICAL TRIALS & OBSERVATIONS
Lymphocytosis and ibrutinib treatment of CLL
Clinical Trials & Observations
CLINICAL TRIALS & OBSERVATIONS
Changing myelofibrosis’s natural course at last
Clinical Trials & Observations
BLOOD WORK
PLENARY PAPER
PERSPECTIVES
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy
Clinical Trials & Observations
Jennifer A. Woyach,Kelly Smucker,Lisa L. Smith,Arletta Lozanski,Yiming Zhong,Amy S. Ruppert,David Lucas,Katie Williams,Weiqiang Zhao,Laura Rassenti,Emanuela Ghia,Thomas J. Kipps,Rose Mantel,Jeffrey Jones,Joseph Flynn,Kami Maddocks,Susan O’Brien,Richard R. Furman,Danelle F. James,Fong Clow,Gerard Lozanski,Amy J. Johnson,John C. Byrd
Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug
CME
Clinical Trials & Observations
Ronan Desmond,Danielle M. Townsley,Bogdan Dumitriu,Matthew J. Olnes,Phillip Scheinberg,Margaret Bevans,Ankur R. Parikh,Kinneret Broder,Katherine R. Calvo,Colin O. Wu,Neal S. Young,Cynthia E. Dunbar
Pomalidomide alone or in combination with low-dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study
Clinical Trials & Observations
Paul G. Richardson,David S. Siegel,Ravi Vij,Craig C. Hofmeister,Rachid Baz,Sundar Jagannath,Christine Chen,Sagar Lonial,Andrzej Jakubowiak,Nizar Bahlis,Kevin Song,Andrew Belch,Noopur Raje,Chaim Shustik,Suzanne Lentzsch,Martha Lacy,Joseph Mikhael,Jeffrey Matous,David Vesole,Min Chen,Mohamed H. Zaki,Christian Jacques,Zhinuan Yu,Kenneth C. Anderson
Impact of ruxolitinib on the natural history of primary myelofibrosis: a comparison of the DIPSS and the COMFORT-2 cohorts
Clinical Trials & Observations
Brief Report
Francesco Passamonti,Margherita Maffioli,Francisco Cervantes,Alessandro Maria Vannucchi,Enrica Morra,Tiziano Barbui,Domenica Caramazza,Lisa Pieri,Elisa Rumi,Heinz Gisslinger,Laurent Knoops,Jean Jaques Kiladjian,Barbara Mora,Norbert Hollaender,Cristiana Pascutto,Claire Harrison,Mario Cazzola
LYMPHOID NEOPLASIA
Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma
Giovanni Franco,Carla Guarnotta,Barbara Frossi,Pier Paolo Piccaluga,Emanuela Boveri,Alessandro Gulino,Fabio Fuligni,Alice Rigoni,Rossana Porcasi,Salvatore Buffa,Elena Betto,Ada Maria Florena,Vito Franco,Emilio Iannitto,Luca Arcaini,Stefano Aldo Pileri,Carlo Pucillo,Mario Paolo Colombo,Sabina Sangaletti,Claudio Tripodo
Telomerase functions beyond telomere maintenance in primary cutaneous T-cell lymphoma
Edith Chevret,Laetitia Andrique,Martina Prochazkova-Carlotti,Jacky Ferrer,David Cappellen,Elodie Laharanne,Yamina Idrissi,Anna Boettiger,Wafa Sahraoui,Florian Ruiz,Anne Pham-Ledard,Beatrice Vergier,Francis Belloc,Pierre Dubus,Marie Beylot-Barry,Jean-Philippe Merlio
SET-NUP214 is a recurrent γδ lineage-specific fusion transcript associated with corticosteroid/chemotherapy resistance in adult T-ALL
Clinical Trials & Observations
Brief Report
Raouf Ben Abdelali,Anne Roggy,Thibaut Leguay,Agata Cieslak,Aline Renneville,Aurore Touzart,Anne Banos,Edouard Randriamalala,Denis Caillot,Bruno Lioure,Alain Devidas,Hossein Mossafa,Claude Preudhomme,Norbert Ifrah,Hervé Dombret,Elizabeth Macintyre,Vahid Asnafi
Contribution of cerebrospinal fluid sCD19 levels to the detection of CNS lymphoma and its impact on disease outcome
Brief Report
Carmen Muñiz,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Lourdes Martín-Martín,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Antonio López,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Blanca Sánchez-González,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Antonio Salar,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Julia Almeida,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Juan-Manuel Sancho,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,José María Ribera,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Cecilia Heras,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Francisco Javier Peñalver,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Marta Gómez,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Eva González-Barca,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Natalia Alonso,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Belén Navarro,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Teresa Olave,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Francisco Sala,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Eulogio Conde,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,José Antonio Márquez,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Elena Cabezudo,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Antonia Cladera,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,María García-Malo,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,María Dolores Caballero,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma,Alberto Orfao,for the Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma
MYELOID NEOPLASIA
Tracing the development of acute myeloid leukemia in CBL syndrome
Brief Report
Heiko Becker,Kenichi Yoshida,Nadja Blagitko-Dorfs,Rainer Claus,Milena Pantic,Mahmoud Abdelkarim,Christoph Niemöller,Christine Greil,Björn Hackanson,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Satoru Miyano,Konstanze Döhner,Susanne Schnittger,Philipp Henneke,Charlotte M. Niemeyer,Christian Flotho,Dietmar Pfeifer,Seishi Ogawa,Michael Lübbert
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via β2 integrins (CD11/CD18)
Ludwig T. Weckbach,Anita Gola,Michael Winkelmann,Sascha M. Jakob,Leopold Groesser,Julia Borgolte,Frank Pogoda,Robert Pick,Monika Pruenster,Josef Müller-Höcker,Elisabeth Deindl,Markus Sperandio,Barbara Walzog
PLATELETS AND THROMBOPOIESIS
The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT platelets in patients with primary platelet function defects
Clinical Trials & Observations
Giuseppe Colucci,Monika Stutz,Sophie Rochat,Tiziana Conte,Marko Pavicic,Marianne Reusser,Evelyne Giabbani,Anh Huynh,Charles Thürlemann,Peter Keller,Lorenzo Alberio
RED CELLS, IRON, AND ERYTHROPOIESIS
Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development
Vikram R. Paralkar,Tejaswini Mishra,Jing Luan,Yu Yao,Andrew V. Kossenkov,Stacie M. Anderson,Margaret Dunagin,Maxim Pimkin,Meghneel Gore,Diana Sun,Neeraja Konuthula,Arjun Raj,Xiuli An,Narla Mohandas,David M. Bodine,Ross C. Hardison,Mitchell J. Weiss
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
VASCULAR BIOLOGY
CORRESPONDENCE
RAS-associated lymphoproliferative disease evolves into severe juvenile myelo-monocytic leukemia
Nina Lanzarotti,Julie Bruneau,Amélie Trinquand,Marie-Claude Stolzenberg,Bénédicte Neven,Julien Fregeac,Eva Levy,Nadia Jeremiah,Felipe Suarez,Nizar Mahlaoui,Alain Fischer,Aude Magerus-Chatinet,Hélène Cavé,Frédéric Rieux-Laucat
Homozygous Southeast Asian ovalocytosis is a severe dyserythropoietic anemia associated with distal renal tubular acidosis
Véronique Picard,Alexis Proust,Marion Eveillard,Joanna F. Flatt,Marie-Laure Couec,Gaêlle Caillaux,Madeleine Fénéant-Thibault,Arie Finkelstein,Martine Raphaël,Jean Delaunay,Lesley J. Bruce,Serge Pissard,Caroline Thomas
CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis
Saravanan Kaliyaperumal,Benjamin Watkins,Prachi Sharma,Scott Furlan,Swetha Ramakrishnan,Cynthia Giver,Anapatricia Garcia,Cynthia Courtney,Heather Knight,Elizabeth Strobert,Eric Elder,Timothy Crenshaw,Bruce R. Blazar,Edmund K. Waller,Susan Westmoreland,Leslie S. Kean
ERRATA
CONTINUING MEDICAL EDUCATION (CME) QUESTIONS
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Cover Image
Cover Image
![issue cover]()
Peripheral blood lymphocytes of patient with Sézary syndrome: neoplastic T-cells appear with a yellow color due to combined immunostaining by anti-CD3 (AlexaFluor 594, red) and anti-CD158e/k (AlexaFluor 488, green). Normal T cells are revealed by staining with only anti-CD3 (AlexaFluor 594, red). Blue color is due to 4′,6′-diamidino-2-phenylindole (DAPI) counterstaining. See the article by Chevret et al on page 1850.
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