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Volume 99, Issue 2

January 15 2002

In this Issue

INSIDE BLOOD
PLENARY PAPERS
REVIEW ARTICLES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Lentiviruses get specific

Cynthia Dunbar

View Articletitled, Lentiviruses get specific

More to TTP than VWFCP

Evan Sadler

View Articletitled, More to TTP than VWFCP

PLENARY PAPERS

Targeting transgene expression to antigen-presenting cells derived from lentivirus-transduced engrafting human hematopoietic stem/progenitor cells

Yan Cui,Jonathan Golob,Erin Kelleher,Zhaohui Ye,Drew Pardoll,Linzhao Cheng

View Articletitled, Targeting transgene expression to antigen-presenting cells derived from lentivirus-transduced engrafting human hematopoietic stem/progenitor cells

REVIEW ARTICLES

Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry

Brunangelo Falini,David Y. Mason

View Articletitled, Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry

CHEMOKINES

Interleukin-10 modulates the sensitivity of peritoneal B lymphocytes to chemokines with opposite effects on stromal cell–derived factor-1 and B-lymphocyte chemoattractant

Karl Balabanian,Arnaud Foussat,Laurence Bouchet-Delbos,Jacques Couderc,Roman Krzysiek,Ali Amara,Françoise Baleux,Alain Portier,Pierre Galanaud,Dominique Emilie

View Articletitled, Interleukin-10 modulates the sensitivity of peritoneal B lymphocytes to chemokines with opposite effects on stromal cell–derived factor-1 and B-lymphocyte chemoattractant

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Factor V Leiden: a genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor–cleaving protease activity
Clinical Trials & Observations

Thomas J. Raife,Steven R. Lentz,Bonnie S. Atkinson,Sara K. Vesely,Martin J. Hessner

View Articletitled, Factor V Leiden: a genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor–cleaving protease activity

Real-time quantitation of minimal residual disease in inv(16)-positive acute myeloid leukemia may indicate risk for clinical relapse and may identify patients in a curable state
Clinical Trials & Observations

Silvia Buonamici,Emanuela Ottaviani,Nicoletta Testoni,Vittorio Montefusco,Giuseppe Visani,Francesca Bonifazi,Marilina Amabile,Carolina Terragna,Deborah Ruggeri,Pier Paolo Piccaluga,Alessandro Isidori,Michele Malagola,Michele Baccarani,Sante Tura,Giovanni Martinelli

View Articletitled, Real-time quantitation of minimal residual disease in inv(16)-positive acute myeloid leukemia may indicate risk for clinical relapse and may identify patients in a curable state

Treatment of von Willebrand disease with a high-purity factor VIII/von Willebrand factor concentrate: a prospective, multicenter study: Presented in part at the meeting of the International Society of Thrombosis and Haemostasis in Washington, DC, August 1999.
Clinical Trials & Observations

Pier M. Mannucci,Juan Chediak,Wahid Hanna,John Byrnes,Marlies Ledford,Bruce M. Ewenstein,Anastassios D. Retzios,Barbara A. Kapelan,Richard S. Schwartz,Craig Kessler,the Alphanate Study Group

View Articletitled, Treatment of von Willebrand disease with a high-purity factor VIII/von Willebrand factor concentrate: a prospective, multicenter study: Presented in part at the meeting of the International Society of Thrombosis and Haemostasis in Washington, DC, August 1999.

GENE THERAPY

Use of blood outgrowth endothelial cells for gene therapy for hemophilia A

Yi Lin,Liming Chang,Anna Solovey,John F. Healey,Pete Lollar,Robert P. Hebbel

View Articletitled, Use of blood outgrowth endothelial cells for gene therapy for hemophilia A

HEMATOPOIESIS

Identification of the earliest prethymic bipotent T/NK progenitor in murine fetal liver

Iyadh Douagi,Francesco Colucci,James P. Di Santo,Ana Cumano

View Articletitled, Identification of the earliest prethymic bipotent T/NK progenitor in murine fetal liver

Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I–cell clones

Christoph Schaniel,Ludovica Bruno,Fritz Melchers,Antonius G. Rolink

View Articletitled, Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I–cell clones

Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5

Kevin D. Bunting,Heath L. Bradley,Teresa S. Hawley,Richard Moriggl,Brian P. Sorrentino,James N. Ihle

View Articletitled, Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5

Differential gene expression profiling of adult murine hematopoietic stem cells

In-Kyung Park,Yaqin He,Fangming Lin,Ole D. Laerum,Qiang Tian,Roger Bumgarner,Christopher A. Klug,Kaijun Li,Christian Kuhr,Michelle J. Doyle,Tao Xie,Michèl Schummer,Yu Sun,Adam Goldsmith,Michael F. Clarke,Irving L. Weissman,Leroy Hood,Linheng Li

View Articletitled, Differential gene expression profiling of adult murine hematopoietic stem cells

Molecular mechanism of transforming growth factor β–mediated cell-cycle modulation in primary human CD34⁺ progenitors

Mo A. Dao,Joseph Hwa,Jan A. Nolta

View Articletitled, Molecular mechanism of transforming growth factor β–mediated cell-cycle modulation in primary human CD34+ progenitors

The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors

Christian W. Scharenberg,Michael A. Harkey,Beverly Torok-Storb

View Articletitled, The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors

Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic intraepithelial lymphocytes and natural killer 1.1⁺ T cells

Sean N. Tucker,Heidi K. Jessup,Hodaka Fujii,Christopher B. Wilson

View Articletitled, Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic intraepithelial lymphocytes and natural killer 1.1+ T cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Cytokine-inducible CD40 expression in human endothelial cells is mediated by interferon regulatory factor-1

Andreas H. Wagner,Matthias Gebauer,Beatrix Pollok-Kopp,Markus Hecker

View Articletitled, Cytokine-inducible CD40 expression in human endothelial cells is mediated by interferon regulatory factor-1

Plasma levels of endothelial protein C receptor respond to anticoagulant treatment

Deborah J. Stearns-Kurosawa,Kandice Swindle,Armando D'Angelo,Patrizia Della Valle,Annalisa Fattorini,Nathalie Caron,Marc Grimaux,Barry Woodhams,Shinichiro Kurosawa

View Articletitled, Plasma levels of endothelial protein C receptor respond to anticoagulant treatment

IMMUNOBIOLOGY

Expression of the recombination-activating genes in extrafollicular lymphocytes but no apparent reinduction in germinal center reactions in human tonsils

Nadine Meru,Andreas Jung,Irith Baumann,Gerald Niedobitek

View Articletitled, Expression of the recombination-activating genes in extrafollicular lymphocytes but no apparent reinduction in germinal center reactions in human tonsils

Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2–deficient mice

Bernhard Lange-Asschenfeldt,Wolfgang Weninger,Paula Velasco,Themis R. Kyriakides,Ulrich H. von Andrian,Paul Bornstein,Michael Detmar

View Articletitled, Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2–deficient mice

Stromal cell–derived factor 1/CXCR4 signaling is critical for early human T-cell development

Carmen Hernández-López,Alberto Varas,Rosa Sacedón,Eva Jiménez,Juan José Muñoz,Agustı́n G. Zapata,Angeles Vicente

View Articletitled, Stromal cell–derived factor 1/CXCR4 signaling is critical for early human T-cell development

CD4⁺CD25⁺ T-cell development is regulated by at least 2 distinct mechanisms

Akira Suto,Hiroshi Nakajima,Kei Ikeda,Shuichi Kubo,Toshinori Nakayama,Masaru Taniguchi,Yasushi Saito,Itsuo Iwamoto

View Articletitled, CD4+CD25+ T-cell development is regulated by at least 2 distinct mechanisms

Quantitative trait loci regulating relative lymphocyte proportions in mouse peripheral blood

Jichun Chen,David E. Harrison

View Articletitled, Quantitative trait loci regulating relative lymphocyte proportions in mouse peripheral blood

The different process of class switching and somatic hypermutation; a novel analysis by CD27⁻ naive B cells

Haruo Nagumo,Kazunaga Agematsu,Norimoto Kobayashi,Koji Shinozaki,Sho Hokibara,Hisashi Nagase,Masaya Takamoto,Kozo Yasui,Kazuo Sugane,Atsushi Komiyama

View Articletitled, The different process of class switching and somatic hypermutation; a novel analysis by CD27− naive B cells

Cooperative binding of c-Myb and Pax-5 activates theRAG-2 promoter in immature B cells

Hiroyuki Kishi,Zhe-Xiong Jin,Xing-Cheng Wei,Takuya Nagata,Tadashi Matsuda,Shigeru Saito,Atsushi Muraguchi

View Articletitled, Cooperative binding of c-Myb and Pax-5 activates theRAG-2 promoter in immature B cells

Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement

Kazunori Inabe,Tomohiro Kurosaki

View Articletitled, Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement

Adoptive transfer of simian immunodeficiency virus (SIV) naı̈ve autologous CD4⁺ cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status

Francois Villinger,Gary T. Brice,Ann E. Mayne,Pavel Bostik,Kazuyasu Mori,Carl H. June,Aftab A. Ansari

View Articletitled, Adoptive transfer of simian immunodeficiency virus (SIV) naı̈ve autologous CD4+ cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status

Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14⁺ monocytes cultured under serum-free conditions

Lyudmila A. Lyakh,Gary K. Koski,Howard A. Young,Sally E. Spence,Peter A. Cohen,Nancy R. Rice

View Articletitled, Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14+ monocytes cultured under serum-free conditions

NEOPLASIA

HLA-G protein up-regulation in primary cutaneous lymphomas is associated with interleukin-10 expression in large cell T-cell lymphomas and indolent B-cell lymphomas

Mirjana Urosevic,Joerg Willers,Beatrix Mueller,Werner Kempf,Guenter Burg,Reinhard Dummer

View Articletitled, HLA-G protein up-regulation in primary cutaneous lymphomas is associated with interleukin-10 expression in large cell T-cell lymphomas and indolent B-cell lymphomas

Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

Brian F. Skinnider,Andrew J. Elia,Randy D. Gascoyne,Bruce Patterson,Lorenz Trumper,Ursula Kapp,Tak W. Mak

View Articletitled, Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10

Ayoma Attygalle,Rajai Al-Jehani,Tim C. Diss,Phillipa Munson,Hongxiang Liu,Ming-Qing Du,Peter G. Isaacson,Ahmet Dogan

View Articletitled, Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10

Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor κB ligand on adult T-cell leukemia cells

Kisato Nosaka,Takeshi Miyamoto,Tatsunori Sakai,Hiroaki Mitsuya,Toshio Suda,Masao Matsuoka

View Articletitled, Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor κB ligand on adult T-cell leukemia cells

P-glycoprotein–actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin

Francesca Luciani,Agnese Molinari,Francesco Lozupone,Annarica Calcabrini,Luana Lugini,Annarita Stringaro,Patrizia Puddu,Giuseppe Arancia,Maurizio Cianfriglia,Stefano Fais

View Articletitled, P-glycoprotein–actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin

The Kaposi sarcoma–associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element

Jiabin An,Alan K. Lichtenstein,Gregory Brent,Matthew B. Rettig

View Articletitled, The Kaposi sarcoma–associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element

Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release

Joya Chandra,Emma Mansson,Vladimir Gogvadze,Scott H. Kaufmann,Freidoun Albertioni,Sten Orrenius

View Articletitled, Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release

Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro

Benjamin M. F. Mow,Joya Chandra,Phyllis A. Svingen,Christopher G. Hallgren,Ellen Weisberg,Timothy J. Kottke,Ven L. Narayanan,Mark R. Litzow,James D. Griffin,Edward A. Sausville,Ayalew Tefferi,Scott H. Kaufmann

View Articletitled, Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro

PHAGOCYTES

Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils

Nikolai A. Maianski,Frederik P. J. Mul,Jaap D. van Buul,Dirk Roos,Taco W. Kuijpers

View Articletitled, Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils

TRANSPLANTATION

Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin

Stanislaw M. Stepkowski,Rebecca A. Erwin-Cohen,Fariba Behbod,Mou-Er Wang,Xienui Qu,Neelam Tejpal,Zsuzsanna S. Nagy,Barry D. Kahan,Robert A. Kirken

View Articletitled, Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin

BRIEF REPORTS

HLA-DR, HLA-DQ, and TAP genes in familial Hodgkin disease
Brief Report

Lea C. Harty,Albert Y. Lin,Alisa M. Goldstein,Elaine S. Jaffe,Mary Carrington,Margaret A. Tucker,William S. Modi

View Articletitled, HLA-DR, HLA-DQ, and TAP genes in familial Hodgkin disease

PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac
Brief Report

Jong Suk Kim,Xiaodong Peng,Pradip K. De,Robert L. Geahlen,Donald L. Durden

View Articletitled, PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac

Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome
Clinical Trials & Observations Brief Report

Elizabeth M. Kang,Moniek de Witte,Harry Malech,Richard A. Morgan,Sheila Phang,Charles Carter,Susan F. Leitman,Richard Childs,A. John Barrett,Richard Little,John F. Tisdale

View Articletitled, Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome

Severe coagulation factor V deficiency caused by 2 novel frameshift mutations: 2952delT in exon 13 and 5493insG in exon 16 of factor 5 gene
Brief Report

Éva Ajzner,István Balogh,Teréz Szabó,Anikó Marosi,Gizella Haramura,László Muszbek

View Articletitled, Severe coagulation factor V deficiency caused by 2 novel frameshift mutations: 2952delT in exon 13 and 5493insG in exon 16 of factor 5 gene

P2X₇ receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia
Brief Report

Elena Adinolfi,Loredana Melchiorri,Simonetta Falzoni,Paola Chiozzi,Anna Morelli,Alessia Tieghi,Antonio Cuneo,Gianluigi Castoldi,Francesco Di Virgilio,Olavio R. Baricordi

View Articletitled, P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia

Lentiviral gene transfer into peripheral blood–derived CD34⁺ NOD/SCID-repopulating cells
Brief Report

Michaela Scherr,Karin Battmer,Ulrike Blömer,Bernd Schiedlmeier,Arnold Ganser,Manuel Grez,Matthias Eder

View Articletitled, Lentiviral gene transfer into peripheral blood–derived CD34+ NOD/SCID-repopulating cells

α₁-Acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571
Brief Report

Heather G. Jørgensen,Moira A. Elliott,Elaine K. Allan,Christine E. Carr,Tessa L. Holyoake,Kevin D. Smith

View Articletitled, α1-Acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571

Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells
Brief Report

James A. L. Fenton,Jan-Willem Vaandrager,Wilhelmina M. Aarts,Richard J. Bende,Karel Heering,Martin van Dijk,Gareth Morgan,Carel J. M. van Noesel,Ed Schuuring,Philip M. Kluin

View Articletitled, Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells

Human hematopoiesis in murine embryos after injecting human cord blood–derived hematopoietic stem cells into murine blastocysts
Brief Report

Friedrich Harder,Reinhard Henschler,Ilse Junghahn,Marinus C. Lamers,Albrecht M. Müller

View Articletitled, Human hematopoiesis in murine embryos after injecting human cord blood–derived hematopoietic stem cells into murine blastocysts

CORRESPONDENCE

Interleukin-15 as a potential costimulatory cytokine in CD154 gene therapy of chronic lymphocytic leukemia

Gabriele Anether,Ingrid Marschitz,Inge Tinhofer,Richard Greil

View Articletitled, Interleukin-15 as a potential costimulatory cytokine in CD154 gene therapy of chronic lymphocytic leukemia

Reconsidering anticoagulant therapy in venous thromboembolism

David K. Cundiff

View Articletitled, Reconsidering anticoagulant therapy in venous thromboembolism

Efficacy of lamivudine to prevent hepatitis reactivation in hepatitis B virus–infected patients treated for non-Hodgkin lymphoma

Marcello Persico,Fedele De Marino,Giovanni Di Giacomo Russo,Alessandro Severino,Bruno Palmentieri,Marco Picardi,Aristide Morante,Bruno Rotoli,Roberto Torella,Amalia De Renzo

View Articletitled, Efficacy of lamivudine to prevent hepatitis reactivation in hepatitis B virus–infected patients treated for non-Hodgkin lymphoma

Language and the clonal myeloid diseases

Marshall A. Lichtman

View Articletitled, Language and the clonal myeloid diseases

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

REVIEW ARTICLES

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Factor V Leiden: a genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor–cleaving protease activity Clinical Trials & Observations

Real-time quantitation of minimal residual disease in inv(16)-positive acute myeloid leukemia may indicate risk for clinical relapse and may identify patients in a curable state Clinical Trials & Observations

Treatment of von Willebrand disease with a high-purity factor VIII/von Willebrand factor concentrate: a prospective, multicenter study: Presented in part at the meeting of the International Society of Thrombosis and Haemostasis in Washington, DC, August 1999. Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

TRANSPLANTATION

BRIEF REPORTS

HLA-DR, HLA-DQ, and TAP genes in familial Hodgkin disease Brief Report

PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac Brief Report

Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome Clinical Trials & Observations Brief Report

Severe coagulation factor V deficiency caused by 2 novel frameshift mutations: 2952delT in exon 13 and 5493insG in exon 16 of factor 5 gene Brief Report

P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia Brief Report

Lentiviral gene transfer into peripheral blood–derived CD34+ NOD/SCID-repopulating cells Brief Report

α1-Acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571 Brief Report

Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells Brief Report

Human hematopoiesis in murine embryos after injecting human cord blood–derived hematopoietic stem cells into murine blastocysts Brief Report