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Journal Articles

Ibrutinib, Fludarabine, Cyclophosphamide and Obinutuzumab (iFCG) for Firstline Treatment of Patients with CLL with Mutated IGHV and without Del(17p)/ TP53 Mutation: Six-Year Follow-up Analyses

Nitin Jain, Philip Thompson, Akhil Jain, Jan A. Burger, Alessandra Ferrajoli, Jayastu Senapati, Koichi Takahashi, Mahesh Swaminathan, Zeev Estrov, Gautam Borthakur, Prithviraj Bose, Tapan M. Kadia, Naveen Pemmaraju, Koji Sasaki, Divyam Bansal, Marina Y. Konopleva, Elias Jabbour, Naveen Garg, Xuemei Wang, Rashmi Kanagal-Shamanna, Keyur P. Patel, Wei Wang, Sa A. Wang, Jeffrey L. Jorgensen, Wanda Lopez, Ana Ayala, William Plunkett, Varsha Gandhi, Hagop M. Kantarjian, Susan M. O'Brien, Michael J. Keating, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3267.
https://doi.org/10.1182/blood-2023-188084
Published: 2023
Journal Articles

Inhibition of EZH2 Improves CART19 Immunotherapy By Reprogramming Lymphoma Tumor Cells and Enhancing T-Cell Functionality

Patrizia Porazzi, Yusuke Isshiki, Guido Ghilardi, Siena Nason, Ziqi Yang, Alberto Carturan, Linhui Chen, Yunlin Zhang, Ruchi P. Patel, Puneeth Guruprasad, Ositadimma Ugwuanyi, Ivan J Cohen, Stephen J Schuster, Ari M Melnick, Wendy Béguelin, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 1018.
https://doi.org/10.1182/blood-2023-182440
Published: 2023
Journal Articles

Azacitidine, Venetoclax and Allogeneic NK Cells in Newly Diagnosed Acute Myeloid Leukemia (ADVENT-AML): An Investigator-Initiated Multicenter Phase Ib Trial

Abhishek Maiti, Muharrem Muftuoglu, James J. Ignatz-Hoover, Courtney D. DiNardo, Farhad Ravandi, Michael Andreeff, Lianchun Xiao, Xuelin Huang, Keyur P. Patel, Jason B Litten, Eliot Bourk, Stephanie Astrow, Hagop M. Kantarjian, Ben K. Tomlinson, Naval Daver, David Wald
Journal: Blood
Blood (2023) 142 (Supplement 1): 4863.
https://doi.org/10.1182/blood-2023-182885
Published: 2023
Journal Articles

Deeper Insight into Splicing Mutations in Myelofibrosis

Julie Braish, Prithviraj Bose, Naveen Pemmaraju, Sherry Pierce, Koji Sasaki, Keyur P. Patel, Hagop Kantarjian, Lucia Masarova
Journal: Blood
Blood (2023) 142 (Supplement 1): 4580.
https://doi.org/10.1182/blood-2023-189168
Published: 2023
Journal Articles

Modulation of the Btla-HVEM Axis to Enhance CAR T Cell Immunotherapy Against Cancer

Puneeth Guruprasad, Alberto Carturan, Yunlin Zhang, Kingsley Gideon Kumashie, Ivan J Cohen, Guido Ghilardi, Ki-Hyun Kim, Jong-Seo Lee, Yoon Lee, Jong-Hoon Kim, Junho Chung, Maksim Shestov, Raymone Pajarillo, Jaryse Harris, Yong Gu Lee, Michael Wang, Hatcher Ballard, Aasha Gupta, Ositadimma Ugwuanyi, Seok Jae Hong, Linhui Chen, Luca Paruzzo, Shane Kammerman, Ruchi P. Patel, Olga Shestova, Laura Vella, Stephen J. Schuster, Jakub Svoboda, Patrizia Porazzi, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 768.
https://doi.org/10.1182/blood-2023-189633
Published: 2023
Journal Articles

Clinical and Prognostic Implications of WT1 Mutations in De Novo and Relapsed Acute Myeloid Leukemia

Himachandana Atluri, Jeremy DiGennaro, Keyur P. Patel, Mark Routbort, Betul Oran, Ghayas C. Issa, Nicholas J. Short, Naval Daver, Tapan M. Kadia, Farhad Ravandi, Uday R. Popat, Richard E. Champlin, Elizabeth J. Shpall, Sherry Pierce, Rashmi Kanagal-Shamanna, Chi Young Ok, Guilin Tang, Sa A. Wang, Raja Luthra, Audrey Lasry, Bettina Nadorp, Antonia Chroni, Ann-Kathrin Eisfeld, Iannis Aifantis, Najla H Al Ali, David A Sallman, Jeffrey Lancet, Onyee Chan, Eric Padron, Zhuoer Xie, L. Jeffrey Medeiros, Courtney D. DiNardo, Rami S. Komrokji, Sanam Loghavi
Journal: Blood
Blood (2023) 142 (Supplement 1): 959.
https://doi.org/10.1182/blood-2023-188319
Published: 2023
Journal Articles

Evaluation of GBT021601 As a Therapeutic Agent to Restore Bone Marrow Health and Effective Erythropoiesis in a Sickle Mouse Model

Britney Hernandez, Anupama Priyadarshini, Zachary Kostamo, Yankai Zhang, Ashwin P Patel, Michael A Pendergast, Madhulika Jupelli, Heli Huang, Annie Nguyen Dang, Mira Patel Pochron, Kobina Dufu, Vivien A Sheehan
Journal: Blood
Blood (2023) 142 (Supplement 1): 16.
https://doi.org/10.1182/blood-2023-175022
Published: 2023
Journal Articles

Primary Analysis and Results of Bendamustine, Rituximab, and Venetoclax (BR-VEN) for Initial Treatment of Mantle Cell Lymphoma in Subjects over 60 Years of Age (PrE0405)

Craig A. Portell, Opeyemi Jegede, N. Nora Bennani, Seema Naik, Christopher M. Reynolds, Priyank P. Patel, Michael J. Robertson, Brad S. Kahl
Journal: Blood
Blood (2023) 142 (Supplement 1): 733.
https://doi.org/10.1182/blood-2023-182374
Published: 2023
Journal Articles

Evaluation of the Impact of a Naturally Occurring Beta Hemoglobin Variant, Hb G-Makassar, on Mature Red Blood Cell Function and Pathology in a Sickle Cell Disease Mouse Model

Zachary Kostamo, Jawa Darazim, Britney Hernandez, Alex Pendergast, Jordan Zgodny, Erica N Evans, Yankai Zhang, Ashwin P Patel, Celeste K. Kanne, Elizabeth Budak, Rebecca Jenkins, Daniel Haupt, Valerie Winton, Bo Yan, Adam Hartigan, Haihua Chu, Giuseppe Ciaramella, Vivien A. Sheehan
Journal: Blood
Blood (2023) 142 (Supplement 1): 2251.
https://doi.org/10.1182/blood-2023-186237
Published: 2023
Journal Articles

A First-in-Human Phase I Study of AT101, a Novel Anti-CD19 Chimeric Antigen Receptor T Cell Product Targeting a Membrane-Proximal Domain of CD19 in Adults with Relapsed or Refractory B Cell Non-Hodgkin Lymphoma

Yunlin Zhang, Ruchi P. Patel, Ki Hyun Kim, Hyungwoo Cho, Jae-Cheol Cho, Seong Hyun Jeong, Sung Yong Oh, Yoon Seok Choi, Sung-Hyun Kim, Ji Hyun Lee, Mathew G. Angelos, Puneeth Guruprasad, Ivan J Cohen, Ositadimma Ugwuanyi, Yong Gu Lee, Raymone Pajarillo, Jong Hyun Cho, Alberto Carturan, Luca Paruzzo, Guido Ghilardi, Soohwan Kim, Sung Min Kim, Hyun Jong Lee, Ji Ho Park, Lei Guang Cui, Tae Bum Lee, Insik Hwang, Youngha Lee, Yong-Jun Lee, Patrizia Porazzi, Dongfang Liu, Yoon Lee, Jong Hoon Kim, Jong Seo Lee, Dok Hyun Yoon, Junho Chung, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 2096.
https://doi.org/10.1182/blood-2023-189369
Published: 2023
Journal Articles

BRAF -Mutated Acute Myeloid Leukemia (AML) Represents a Distinct, Prognostically Poor Subgroup Enriched in Myelodysplasia-Related (MR-)AML

Yazan Abu-Shihab, Deedra Nicolet, Krzysztof Mrózek, Mark Routbort, Keyur P. Patel, Christopher J. Walker, Jill Buss, Andrew Stiff, Andrea Laganson, Courtney D. DiNardo, Naval Daver, Tapan M. Kadia, Gautam Borthakur, Farhad Ravandi, Andrew J Carroll, Jonathan E Kolitz, Bayard L Powell, William Blum, Maria R. Baer, Guido Marcucci, Geoffrey L Uy, Wendy Stock, Richard M Stone, L. Jeffrey Medeiros, Robert L. Bowman, John C. Byrd, James S. Blachly, Linde A. Miles, Ann-Kathrin Eisfeld, Sanam Loghavi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1575.
https://doi.org/10.1182/blood-2023-185135
Published: 2023
Journal Articles

Acalabrutinib with Rituximab As First-Line Therapy for Older Patients with Mantle Cell Lymphoma - a Phase II Clinical Trial

Preetesh Jain, Chi Young OK, Loretta J. Nastoupil, Jason Westin, Holly A Hill, Ranjit Nair, Swami P. Iyer, Ahmed Fetooh, Hun Ju Lee, Sairah Ahmed, Rashmi Kanagal-Shamanna, Fatima Z Jelloul, Luis Enrique Malpica Castillo, Yang Liu, Yijing Li, Jovanny Vargas, Lei Feng, Maria Badillo, Selvi Thirumurthi, Guofan Xu, Anita Deswal, Cezar Iliescu, Vinh Quang Nguyen, Guilin Tang, Keyur P. Patel, Francisco Vega, L. Jeffrey Medeiros, Michael L. Wang, Christopher R. Flowers
Journal: Blood
Blood (2023) 142 (Supplement 1): 3036.
https://doi.org/10.1182/blood-2023-181216
Published: 2023
Journal Articles

Radchip: A Laminin-Lined Red Blood Cell (RBC) Adhesion Device for Functional Characterization and Clinical Evaluation of Sickle RBCs at Steady-State

Erica N Evans, Evelyn K Williams, Celeste K. Kanne, Kirby A Fibben, Ashwin P. Patel, Lindsey Abel, Meredith Ellen Fay, Akshay A Patwardhan, Jawa Darazim, Zachary Kostamo, Wilbur Lam, Vivien A. Sheehan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3657.
https://doi.org/10.1182/blood-2023-186769
Published: 2023
Journal Articles

Fratricide-Resistant Anti-CD2 Chimeric Antigen Receptor T-Cells with Endogenous CD2 Knockout Are Highly Effective Against T-Cell Neoplasms

Mathew G. Angelos, Ruchi P. Patel, Yi-Hao Chiang, Wei Xie, Raymone Pajarillo, Carolyn E. Shaw, Ekta Singh, Jason Xu, Avery D. Posey, Alain Rook, Antonia Rotolo, Vinodh Pillai, Stefano A. Pileri, David T. Teachey, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 885.
https://doi.org/10.1182/blood-2023-181282
Published: 2023
Journal Articles

TP53 Y220C Mutations in Patients with Myeloid Malignancies

Georgina Gener-Ricos, Jan Philipp Bewersdorf, Sanam Loghavi, Aaron D. Goldberg, Christopher Famulare, Ghayas C. Issa, Gautam Borthakur, Tapan M. Kadia, Bing Z. Carter, Keyur P. Patel, Michael Andreeff, Eytan M. Stein, Courtney D. DiNardo
Journal: Blood
Blood (2023) 142 (Supplement 1): 1477.
https://doi.org/10.1182/blood-2023-189343
Published: 2023
Journal Articles

Senza5 TM CART5 : An Autologous CD5-Deleted Anti-CD5 CART Product with Enhanced Anti-T-Cell Lymphoma Activity

Adam E. Snook, Ruchi P. Patel, Guido Ghilardi, Aditya Nimmagadda, Steven Yang, Dean Qian, Patrizia Porazzi, Rosemary Mazanet, Stephen J Schuster, Stefan K. Barta, Trang Vu, Marco Ruella, Nicholas A. Siciliano
Journal: Blood
Blood (2023) 142 (Supplement 1): 3462.
https://doi.org/10.1182/blood-2023-190386
Published: 2023
Journal Articles

Phase I/II Study of Quizartinib, Venetoclax, and Decitabine Triple Combination in FLT3-ITD Mutated AML

Musa Yilmaz, Muharrem Muftuoglu, Courtney D. DiNardo, Tapan M. Kadia, Marina Y. Konopleva, Gautam Borthakur, Naveen Pemmaraju, Nicholas J. Short, Yesid Alvarado Valero, Abhishek Maiti, Lucia Masarova, Guillermo Montalban-Bravo, Carissa Jurisprudencia, Allison Pike, Sanam Loghavi, Keyur P. Patel, Guilin Tang, Jairo Matthews, Steven M. Kornblau, Elias Jabbour, Guillermo Garcia-Manero, Farhad Ravandi, Michael Andreeff, Naval Daver
Journal: Blood
Blood (2023) 142 (Supplement 1): 158.
https://doi.org/10.1182/blood-2023-186699
Published: 2023
Journal Articles

Red Cell Rheology and Blood Viscosity in Pediatric Individuals Having Received Allogenic Hematopoietic Stem Cell Transplantation or Ex Vivo Autologous Gene Therapy for Sickle Cell Disease

Ashwin P. Patel, Celeste K. Kanne, Elizabeth O Stenger, Tami D. John, Vivien A. Sheehan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1076.
https://doi.org/10.1182/blood-2023-188045
Published: 2023
Journal Articles

Impact of Vaso-Occlusive Crises on the Transcriptomes of Patients with Sickle Cell Disease

Varsha Bhat, Alka A Potdar, Ashwin P Patel, Gregory Gibson, G. Karen Yu, Vivien A Sheehan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1116.
https://doi.org/10.1182/blood-2023-179366
Published: 2023
Journal Articles

Rheological Characteristics of Elderly Individuals with Sickle Cell Disease Compared with an Adult Sickle Cell Population

Justin J Yoo, Jordan Zgodny, Britney Hernandez, Jawa Darazim, Ashwin P Patel, Fuad El Rassi, G. Karen Yu, Alka A Potdar, Vivien A. Sheehan
Journal: Blood
Blood (2023) 142 (Supplement 1): 926.
https://doi.org/10.1182/blood-2023-177791
Published: 2023