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Issue Archive

Volume 113, Issue 3
January 15 2009
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
MYB and miR: a pair well matched
Marc A. Kerenyi,Ernst W. Müllner
View Articletitled, MYB and miR: a pair well matched
THROMBOSIS & HEMOSTASIS
Bleeding hearts
Nigel Mackman
View Articletitled, Bleeding hearts
CLINICAL TRIALS
At least Type VWD2B is a discrete variant of VWD, isn't it?
Robert R. Montgomery
View Articletitled, At least Type VWD2B is a discrete variant of VWD, isn't it?

EDITORIALS

“Ghostbusting” at Blood
Cynthia E. Dunbar,Martin S. Tallman
View Articletitled, “Ghostbusting” at <em>Blood</em>

PLENARY PAPERS

The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells
Huiwu Zhao,Anna Kalota,Shenghao Jin,Alan M. Gewirtz
View Articletitled, The c-<em>myb</em> proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells

REVIEW ARTICLES

The role of Dickkopf-1 in bone development, homeostasis, and disease
Joseph J. Pinzone,Brett M. Hall,Nanda K. Thudi,Martin Vonau,Ya-Wei Qiang,Thomas J. Rosol,John D. Shaughnessy, Jr
View Articletitled, The role of Dickkopf-1 in bone development, homeostasis, and disease

CLINICAL TRIALS AND OBSERVATIONS

Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients
Clinical Trials & Observations
Augusto B. Federici,Pier M. Mannucci,Giancarlo Castaman,Luciano Baronciani,Paolo Bucciarelli,Maria T. Canciani,Alessandro Pecci,Peter J. Lenting,Philip G. De Groot
View Articletitled, Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients
Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab
Brief Report
Farrukh T. Awan,Neil E. Kay,Melanie E. Davis,Wenting Wu,Susan M. Geyer,Nelson Leung,Diane F. Jelinek,Renee C. Tschumper,Charla R. Secreto,Thomas S. Lin,Michael R. Grever,Tait D. Shanafelt,Clive S. Zent,Timothy G. Call,Nyla A. Heerema,Gerard Lozanski,John C. Byrd,David M. Lucas
View Articletitled, Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab

GENE THERAPY

Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector–mediated gene therapy
Victoria M. Velazquez,David G. Bowen,Christopher M. Walker
View Articletitled, Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector–mediated gene therapy
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation
Tiago C. Luis,Floor Weerkamp,Brigitta A. E. Naber,Miranda R. M. Baert,Edwin F. E. de Haas,Tatjana Nikolic,Sjanneke Heuvelmans,Ronald R. De Krijger,Jacques J. M. van Dongen,Frank J. T. Staal
View Articletitled, Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation
Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration
Masaya Ueno,Machiko Itoh,Kazushi Sugihara,Masahide Asano,Nobuyuki Takakura
View Articletitled, Both alleles of <em>PSF1</em> are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration
Supplemental data
Both primitive and definitive blood cells are derived from Flk-1+ mesoderm
Brief Report
Jesse J. Lugus,Changwon Park,Yunglin D. Ma,Kyunghee Choi
View Articletitled, Both primitive and definitive blood cells are derived from Flk-1<sup>+</sup> mesoderm

IMMUNOBIOLOGY

Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner
Lizhen Chen,Shiyun Xiao,Nancy R. Manley
View Articletitled, Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner
Supplemental data
Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck
Manik C. Ghosh,Dolgor Baatar,Gary Collins,Arnell Carter,Fred Indig,Arya Biragyn,Dennis D. Taub
View Articletitled, Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck
Supplemental data
Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells
Zania Stamataki,Claire Shannon-Lowe,Jean Shaw,David Mutimer,Alan B. Rickinson,John Gordon,David H. Adams,Peter Balfe,Jane A. McKeating
View Articletitled, Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells
Supplemental data
Extracellular ligation-dependent CD45RB enzymatic activity negatively regulates lipid raft signal transduction
Kaushal Parikh,Sibrand Poppema,Maikel P. Peppelenbosch,Lydia Visser
View Articletitled, Extracellular ligation-dependent CD45RB enzymatic activity negatively regulates lipid raft signal transduction
Supplemental data
Functional Epstein-Barr virus reservoir in plasma cells derived from infected peripheral blood memory B cells
Yassine Al Tabaa,Edouard Tuaillon,Karine Bollore,Vincent Foulongne,Gael Petitjean,Jean-Marie Seigneurin,Christophe Duperray,Claude Desgranges,Jean-Pierre Vendrell
View Articletitled, Functional Epstein-Barr virus reservoir in plasma cells derived from infected peripheral blood memory B cells
Supplemental data
Bone marrow–based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis
Mirko Paiardini,Barbara Cervasi,Jessica C. Engram,Shari N. Gordon,Nichole R. Klatt,Alagarraju Muthukumar,James Else,Robert S. Mittler,Silvija I. Staprans,Donald L. Sodora,Guido Silvestri
View Articletitled, Bone marrow–based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis
Impaired negative regulation of homeostatically proliferating T cells
Brief Report
Anna Shvets,Rabindranath Chakrabarti,Rosana Gonzalez-Quintial,Roberto Baccala,Argyrios N. Theofilopoulos,Gérald J. Prud'homme
View Articletitled, Impaired negative regulation of homeostatically proliferating T cells
Supplemental data

LYMPHOID NEOPLASIA

Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia
Xavier Leleu,Lian Xu,Xiaoying Jia,Antonio Sacco,Mena Farag,Zachary R. Hunter,Anne-Sophie Moreau,Hai T. Ngo,Evdoxia Hatjiharissi,Allen W. Ho,Daniel D. Santos,Sofia Adamia,Kelly O'Connor,Bryan Ciccarelli,Jacob Soumerai,Robert J. Manning,Christopher J. Patterson,Aldo M. Roccaro,Irene M. Ghobrial,Steven P. Treon
View Articletitled, Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia
Gene expression profiling of pulmonary mucosa-associated lymphoid tissue lymphoma identifies new biologic insights with potential diagnostic and therapeutic applications
Wee J. Chng,Ellen D. Remstein,Rafael Fonseca,P. Leif Bergsagel,Julie A. Vrana,Paul J. Kurtin,Ahmet Dogan
View Articletitled, Gene expression profiling of pulmonary mucosa-associated lymphoid tissue lymphoma identifies new biologic insights with potential diagnostic and therapeutic applications
Supplemental data
Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia
Brief Report
Lyndal Kearney,David Gonzalez De Castro,Jenny Yeung,Julia Procter,Sharon W. Horsley,Minenori Eguchi-Ishimae,Caroline M. Bateman,Kristina Anderson,Tracy Chaplin,Bryan D. Young,Christine J. Harrison,Helena Kempski,Chi Wai E. So,Anthony M. Ford,Mel Greaves
View Articletitled, Specific <em>JAK2</em> mutation (<em>JAK2</em>R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia
Supplemental data

MYELOID NEOPLASIA

Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD
Andrew J. Mhyre,A. Mario Marcondes,Emily Y. Spaulding,H. Joachim Deeg
View Articletitled, Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD
Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines
Taichun Qin,Jaroslav Jelinek,Jiali Si,Jingmin Shu,Jean-Pierre J. Issa
View Articletitled, Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

In vivo expansion of cells expressing acquired CSF3R mutations in patients with severe congenital neutropenia
Brief Report
Manuela Germeshausen,Karl Welte,Matthias Ballmaier
View Articletitled, In vivo expansion of cells expressing acquired <em>CSF3R</em> mutations in patients with severe congenital neutropenia
Supplemental data
Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection
Brief Report
Xu Wang,Li Ye,Wei Hou,Yu Zhou,Yan-Jian Wang,David S. Metzger,Wen-Zhe Ho
View Articletitled, Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection

PLATELETS AND THROMBOPOIESIS

R93W mutation in Orai1 causes impaired calcium influx in platelets
Brief Report
Wolfgang Bergmeier,Masatsugu Oh-hora,Christie-Ann McCarl,R. Claire Roden,Paul F. Bray,Stefan Feske
View Articletitled, R93W mutation in Orai1 causes impaired calcium influx in platelets
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism
Dunja Ferring-Appel,Matthias W. Hentze,Bruno Galy
View Articletitled, Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism
Supplemental data
Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness
Jaroslav Truksa,Pauline Lee,Ernest Beutler
View Articletitled, Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness
Supplemental data

THROMBOSIS AND HEMOSTASIS

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain
Eric S. Mullins,Keith W. Kombrinck,Kathryn E. Talmage,Maureen A. Shaw,David P. Witte,Joni M. Ullman,Sandra J. Degen,William Sun,Matthew J. Flick,Jay L. Degen
View Articletitled, Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain
Supplemental data
Vascular smooth muscle–derived tissue factor is critical for arterial thrombosis after ferric chloride–induced injury
Li Wang,Christine Miller,Robert F. Swarthout,Mohan Rao,Nigel Mackman,Mark B. Taubman
View Articletitled, Vascular smooth muscle–derived tissue factor is critical for arterial thrombosis after ferric chloride–induced injury
A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells
Aya Shibamiya,Karin Hersemeyer,Thomas Schmidt Wöll,Daniel Sedding,Jan-Marcus Daniel,Stefan Bauer,Takatoshi Koyama,Klaus T. Preissner,Sandip M. Kanse
View Articletitled, A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells
Supplemental data
Severe bleeding complications caused by an autoantibody against the B subunit of plasma factor XIII: a novel form of acquired factor XIII deficiency
Brief Report
Éva Ajzner,Ágota Schlammadinger,Adrienne Kerényi,Zsuzsanna Bereczky,Éva Katona,Gizella Haramura,Zoltán Boda,László Muszbek
View Articletitled, Severe bleeding complications caused by an autoantibody against the B subunit of plasma factor XIII: a novel form of acquired factor XIII deficiency

TRANSPLANTATION

Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia
Sarah Cooley,Elizabeth Trachtenberg,Tracy L. Bergemann,Koy Saeteurn,John Klein,Chap T. Le,Steven G. E. Marsh,Lisbeth A. Guethlein,Peter Parham,Jeffrey S. Miller,Daniel J. Weisdorf
View Articletitled, Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia
Supplemental data
Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT
Allison L. Bayer,Monica Jones,Jackeline Chirinos,Lesley de Armas,Taylor H. Schreiber,Thomas R. Malek,Robert B. Levy
View Articletitled, Host CD4<sup>+</sup>CD25<sup>+</sup> T cells can expand and comprise a major component of the Treg compartment after experimental HCT
Supplemental data

VASCULAR BIOLOGY

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression
Yixin Tang,Elizabeth A. Scheef,Shoujian Wang,Christine M. Sorenson,Craig B. Marcus,Colin R. Jefcoate,Nader Sheibani
View Articletitled, CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression
Supplemental data
Critical role of scavenger receptor-BI–expressing bone marrow–derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer
Yingmei Feng,Miranda van Eck,Eline Van Craeyveld,Frank Jacobs,Vincent Carlier,Sophie Van Linthout,Martin Erdel,Marc Tjwa,Bart De Geest
View Articletitled, Critical role of scavenger receptor-BI–expressing bone marrow–derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer
Supplemental data
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