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A longer acting rFVIII, safe and effective
Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A
Early assessment of minimal residual disease identifies patients at very high relapse risk in NPM-ALK–positive anaplastic large-cell lymphoma
Issue Archive
January 16 2014
In this Issue
Table of Contents
INSIDE BLOOD
CLINICAL TRIALS & OBSERVATIONS
A longer acting rFVIII, safe and effective
Clinical Trials & Observations
BLOOD WORK
PLENARY PAPER
Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A
Clinical Trials & Observations
Johnny Mahlangu,Jerry S. Powell,Margaret V. Ragni,Pratima Chowdary,Neil C. Josephson,Ingrid Pabinger,Hideji Hanabusa,Naresh Gupta,Roshni Kulkarni,Patrick Fogarty,David Perry,Amy Shapiro,K. John Pasi,Shashikant Apte,Ivan Nestorov,Haiyan Jiang,Shuanglian Li,Srividya Neelakantan,Lynda M. Cristiano,Jaya Goyal,Jurg M. Sommer,Jennifer A. Dumont,Nigel Dodd,Karen Nugent,Gloria Vigliani,Alvin Luk,Aoife Brennan,Glenn F. Pierce,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators,for the A-LONG Investigators
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
Early assessment of minimal residual disease identifies patients at very high relapse risk in NPM-ALK–positive anaplastic large-cell lymphoma
Clinical Trials & Observations
Brief Report
Christine Damm-Welk,Lara Mussolin,Martin Zimmermann,Marta Pillon,Wolfram Klapper,Ilske Oschlies,Emanuele S. G. d’Amore,Alfred Reiter,Wilhelm Woessmann,Angelo Rosolen
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell–engaging antibody AMG 330
Christina Krupka,Peter Kufer,Roman Kischel,Gerhard Zugmaier,Jan Bögeholz,Thomas Köhnke,Felix S. Lichtenegger,Stephanie Schneider,Klaus H. Metzeler,Michael Fiegl,Karsten Spiekermann,Patrick A. Baeuerle,Wolfgang Hiddemann,Gert Riethmüller,Marion Subklewe
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
A. A. Roger Thompson,Philip M. Elks,Helen M. Marriott,Suttida Eamsamarng,Kathryn R. Higgins,Amy Lewis,Lynne Williams,Selina Parmar,Gary Shaw,Emmet E. McGrath,Federico Formenti,Fredericus J. Van Eeden,Vuokko L. Kinnula,Christopher W. Pugh,Ian Sabroe,David H. Dockrell,Edwin R. Chilvers,Peter A. Robbins,Melanie J. Percy,M. Celeste Simon,Randall S. Johnson,Stephen A. Renshaw,Moira K. B. Whyte,Sarah R. Walmsley
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSFUSION MEDICINE
TRANSPLANTATION
Small molecule Me6TREN mobilizes hematopoietic stem/progenitor cells by activating MMP-9 expression and disrupting SDF-1/CXCR4 axis
Jing Zhang,Xiangliang Ren,Wei Shi,Sihan Wang,Haixu Chen,Bowen Zhang,Zhidong Wang,Yong Zhou,Lin Chen,Rui Zhang,Yang Lv,Junnian Zhou,Xue Nan,Lijuan He,Wen Yue,Yanhua Li,Xuetao Pei
VASCULAR BIOLOGY
G protein–dependent basal and evoked endothelial cell vWF secretion
Luiza Rusu,Alexandra Andreeva,David J. Visintine,Kyungho Kim,Stephen M. Vogel,Aleksandra Stojanovic-Terpo,Olga Chernaya,Guoquan Liu,Farnaz R. Bakhshi,Sandra L. Haberichter,Hiroko Iwanari,Osamu Kusano-Arai,Nobuchika Suzuki,Takao Hamakubo,Tohru Kozasa,Jaehyung Cho,Xiaoping Du,Richard D. Minshall
CORRESPONDENCE
ERRATA
CONTINUING MEDICAL EDUCATION (CME) QUESTIONS
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Cover Image
Cover Image
![issue cover]()
Confocal image of von Willebrand factor (vWF), immunostaining (green), and DAPI nuclear staining (blue) in endothelial-cell Weibel-Palade bodies (WPBs) (Zeiss LSM510: 63× 1.2 NA objective; 405/488 nm ex lasers; 2048 × 2048 pixel image size; and pinhole set to achieve 1 Airy unit). The authors describe the role of Ga12 and Gaq/11 in RhoA- and Ca2+/a-SNAP–dependent mobilization and fusion of WPBs. They demonstrate that direct interaction of Gα12 with α-SNAP serves as a catalyst for basal and evoked vWF secretion. See the article by Rusu et al on page 442.
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