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Issue Archive

Volume 124, Issue 13
September 25 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
cGVHD B(r)egs to differ
Karina Yazdanbakhsh
View Articletitled, cGVHD B(r)egs to differ
INSIDE BLOOD COMMENTARY
CCN1: a sticky issue in myeloma
G. David Roodman
View Articletitled, CCN1: a sticky issue in myeloma
INSIDE BLOOD COMMENTARY
To Gli or not to Gli
Lawrence H. Boise
View Articletitled, To Gli or not to Gli
INSIDE BLOOD COMMENTARY
ST1926 repression of Tax: ATL targeted treatment?
Raymond Césaire,Jean-Côme Meniane
View Articletitled, ST1926 repression of Tax: ATL targeted treatment?
INSIDE BLOOD COMMENTARY
VTE risk and family history: provocative findings
David A. Garcia
View Articletitled, VTE risk and family history: provocative findings
INSIDE BLOOD COMMENTARY
Intravascular hemolysis: the sacrifice of few…
Serge L. Y. Thomas
View Articletitled, Intravascular hemolysis: the sacrifice of few…

REVIEW ARTICLE

Src family kinases: at the forefront of platelet activation
Yotis A. Senis,Alexandra Mazharian,Jun Mori
View Articletitled, Src family kinases: at the forefront of platelet activation

HEMATOPOIESIS AND STEM CELLS

The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells
Zhenhua Yang,Jonathan Augustin,Chenbei Chang,Jing Hu,Kushani Shah,Chia-Wei Chang,Tim Townes,Hao Jiang
View Articletitled, The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells
Supplemental data

IMMUNOBIOLOGY

Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD
Ahmad Khoder,Anushruti Sarvaria,Abdullah Alsuliman,Claude Chew,Takuya Sekine,Nichola Cooper,Stephan Mielke,Hugues de Lavallade,Muharrem Muftuoglu,Irina Fernandez Curbelo,Enli Liu,Paolo A. Muraro,Amin Alousi,Kate Stringaris,Simrit Parmar,Nina Shah,Hila Shaim,Eric Yvon,Jeffrey Molldrem,Rayne Rouce,Richard Champlin,Ian McNiece,Claudia Mauri,Elizabeth J. Shpall,Katayoun Rezvani
View Articletitled, Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD
Supplemental data
A nonsense mutation in IKBKB causes combined immunodeficiency
Brief Report
Talal Mousallem,Jialong Yang,Thomas J. Urban,Hongxia Wang,Mehdi Adeli,Roberta E. Parrott,Joseph L. Roberts,David B. Goldstein,Rebecca H. Buckley,Xiao-Ping Zhong
View Articletitled, A nonsense mutation in <em>IKBKB</em> causes combined immunodeficiency
Supplemental data

LYMPHOID NEOPLASIA

CYR61/CCN1 overexpression in the myeloma microenvironment is associated with superior survival and reduced bone disease
Sarah K. Johnson,James P. Stewart,Rakesh Bam,Pingping Qu,Bart Barlogie,Frits van Rhee,John D. Shaughnessy, Jr,Joshua Epstein,Shmuel Yaccoby
View Articletitled, <em>CYR61</em>/CCN1 overexpression in the myeloma microenvironment is associated with superior survival and reduced bone disease
Supplemental data
A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance
Zhiqiang Liu,Jingda Xu,Jin He,Yuhuan Zheng,Haiyan Li,Yong Lu,Jianfei Qian,Pei Lin,Donna M. Weber,Jing Yang,Qing Yi
View Articletitled, A critical role of autocrine sonic hedgehog signaling in human CD138<sup>+</sup> myeloma cell survival and drug resistance
Supplemental data
Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma
Hiba El Hajj,Bariaa Khalil,Botheina Ghandour,Rihab Nasr,Sharif Shahine,Akram Ghantous,Rana Abdel-Samad,Ansam Sinjab,Hideki Hasegawa,Mark Jabbour,William W. Hall,Ghazi Zaatari,Ghassan Dbaibo,Claudio Pisano,Ali Bazarbachi,Nadine Darwiche
View Articletitled, Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma
Supplemental data
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma
Alexander Hoellein,Mohammad Fallahi,Stephanie Schoeffmann,Sabine Steidle,Franz X. Schaub,Martina Rudelius,Iina Laitinen,Lisa Nilsson,Andrei Goga,Christian Peschel,Jonas A. Nilsson,John L. Cleveland,Ulrich Keller
View Articletitled, Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma
Supplemental data

MYELOID NEOPLASIA

X chromosome inactivation analysis reveals a difference in the biology of ET patients with JAK2 and CALR mutations
Brief Report
Christopher Allen,Jonathan R. Lambert,David C. Linch,Rosemary E. Gale
View Articletitled, X chromosome inactivation analysis reveals a difference in the biology of ET patients with <em>JAK2</em> and <em>CALR</em> mutations
miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis
e-blood
Ruggiero Norfo,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Roberta Zini,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Valentina Pennucci,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Elisa Bianchi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Simona Salati,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Paola Guglielmelli,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Costanza Bogani,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Tiziana Fanelli,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Carmela Mannarelli,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Vittorio Rosti,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Daniela Pietra,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Silvia Salmoiraghi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Andrea Bisognin,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Samantha Ruberti,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Sebastiano Rontauroli,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Giorgia Sacchi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Zelia Prudente,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Giovanni Barosi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Mario Cazzola,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Alessandro Rambaldi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Stefania Bortoluzzi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Sergio Ferrari,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Enrico Tagliafico,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Alessandro M. Vannucchi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Rossella Manfredini,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators
View Articletitled, miRNA-mRNA integrative analysis in primary myelofibrosis CD34<sup>+</sup> cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis
Supplemental data

PLATELETS AND THROMBOPOIESIS

Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells
Jinlin Jiang,Donna S. Woulfe,Eleftherios T. Papoutsakis
View Articletitled, Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells
Supplemental data
JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation
Rodolphe Besancenot,Damien Roos-Weil,Carole Tonetti,Hadjer Abdelouahab,Catherine Lacout,Florence Pasquier,Christophe Willekens,Philippe Rameau,Yann Lecluse,Jean-Baptiste Micol,Stefan N. Constantinescu,William Vainchenker,Eric Solary,Stéphane Giraudier
View Articletitled, JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism
Claire Mayeur,Patricio A. Leyton,Starsha A. Kolodziej,Binglan Yu,Kenneth D. Bloch
View Articletitled, BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism
Supplemental data

THROMBOSIS AND HEMOSTASIS

Factors that predict thrombosis in relatives of patients with venous thromboembolism
Francis Couturaud,Christophe Leroyer,Cecile Tromeur,Jim A. Julian,Susan R. Kahn,Jeffrey S. Ginsberg,Philip S. Wells,James D. Douketis,Dominique Mottier,Clive Kearon
View Articletitled, Factors that predict thrombosis in relatives of patients with venous thromboembolism
Supplemental data

TRANSPLANTATION

Donor CD4+ Foxp3+ regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice
Sudipto Ganguly,Duncan B. Ross,Angela Panoskaltsis-Mortari,Christopher G. Kanakry,Bruce R. Blazar,Robert B. Levy,Leo Luznik
View Articletitled, Donor CD4<sup>+</sup> Foxp3<sup>+</sup> regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice
Supplemental data

VASCULAR BIOLOGY

Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy
George Haddad,Pavel Zhabyeyev,Maikel Farhan,Lin Fu Zhu,Zamaneh Kassiri,David C. Rayner,Bart Vanhaesebroeck,Gavin Y. Oudit,Allan G. Murray
View Articletitled, Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy
Supplemental data
Hemolysis is a primary ATP-release mechanism in human erythrocytes
Jacek Sikora,Sergei N. Orlov,Kishio Furuya,Ryszard Grygorczyk
View Articletitled, Hemolysis is a primary ATP-release mechanism in human erythrocytes
Supplemental data

BLOOD WORK

Hematoidin
Kenneth Hennrick,David Yang
View Articletitled, Hematoidin
Diffuse large B-cell lymphoma in leukemic phase
Biswadip Hazarika
View Articletitled, Diffuse large B-cell lymphoma in leukemic phase
  • Cover Image

    Cover Image

    issue cover

    Biomechanical and notably shear forces are essential for megakaryocytic maturation and platelet biogenesis, but also for generating megakaryocytic microparticles, which are capable of programming hematopoietic stem and progenitor cells to differentiate into megakaryocytes. This immunofluorescent image shows a partially disintegrated human polyploid megakaryocyte giving rise to various megakaryocytic particles through β1 tubulin (green) extensions. F-actin is shown in red and the nuclear structures are shown in blue (TO-PRO-3). See the article by Jiang et al on page 2094.

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