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Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia
A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial
A phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1
Issue Archive
August 12 2010
In this Issue
Table of Contents
Inside Blood
Editorial
Plenary Paper
Perspectives
Clinical Trials and Observations
Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia
Clinical Trials & Observations
Kumudha Balakrishnan,Dushyant Verma,Susan O'Brien,John Michael Kilpatrick,Yuling Chen,Brenita F. Tyler,Susan Bickel,Shanta Bantia,Michael J. Keating,Hagop Kantarjian,Varsha Gandhi,Farhad Ravandi
Gene therapy
A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells
Sheng Zhou,Disha Mody,Suk See DeRavin,Julia Hauer,Taihe Lu,Zhijun Ma,Salima Hacein-Bey Abina,John T. Gray,Michael R. Greene,Marina Cavazzana-Calvo,Harry L. Malech,Brian P. Sorrentino
Hematopoiesis and Stem Cells
Immunobiology
Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing
Rémy T. Boscacci,Friederike Pfeiffer,Kathrin Gollmer,Ana Isabel Checa Sevilla,Ana Maria Martin,Silvia Fernandez Soriano,Daniela Natale,Sarah Henrickson,Ulrich H. von Andrian,Yoshinori Fukui,Mario Mellado,Urban Deutsch,Britta Engelhardt,Jens V. Stein
Lymphoid Neoplasia
microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival
Simona Rossi,Masayoshi Shimizu,Elisa Barbarotto,Milena S. Nicoloso,Federica Dimitri,Deepa Sampath,Muller Fabbri,Susan Lerner,Lynn L. Barron,Laura Z. Rassenti,Li Jiang,Lianchun Xiao,Jianhua Hu,Paola Secchiero,Giorgio Zauli,Stefano Volinia,Massimo Negrini,William Wierda,Thomas J. Kipps,William Plunkett,Kevin R. Coombes,Lynne V. Abruzzo,Michael J. Keating,George A. Calin
Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling
Elena M. Hartmann,Elias Campo,George Wright,Georg Lenz,Itziar Salaverria,Pedro Jares,Wenming Xiao,Rita M. Braziel,Lisa M. Rimsza,Wing-Chung Chan,Dennis D. Weisenburger,Jan Delabie,Elaine S. Jaffe,Randy D. Gascoyne,Sandeep S. Dave,Hans-Konrad Mueller-Hermelink,Louis M. Staudt,German Ott,Sílvia Beà,Andreas Rosenwald
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)
Kinuko Hirose,Takeshi Inukai,Jiro Kikuchi,Yusuke Furukawa,Tomokatsu Ikawa,Hiroshi Kawamoto,S. Helen Oram,Berthold Göttgens,Nobutaka Kiyokawa,Yoshitaka Miyagawa,Hajime Okita,Koshi Akahane,Xiaochun Zhang,Itaru Kuroda,Hiroko Honna,Keiko Kagami,Kumiko Goi,Hidemitsu Kurosawa,A. Thomas Look,Hirotaka Matsui,Toshiya Inaba,Kanji Sugita
Myeloid Neoplasia
A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial
Clinical Trials & Observations
Christoph Röllig,Christian Thiede,Martin Gramatzki,Walter Aulitzky,Heinrich Bodenstein,Martin Bornhäuser,Uwe Platzbecker,Reingard Stuhlmann,Ulrich Schuler,Silke Soucek,Michael Kramer,Brigitte Mohr,Uta Oelschlaegel,Friedrich Stölzel,Malte von Bonin,Martin Wermke,Hannes Wandt,Gerhard Ehninger,Markus Schaich,for the Study Alliance Leukemia
Phagocytes, Granulocytes, and Myelopoiesis
A phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1
Clinical Trials & Observations
Elena Lukina,Nora Watman,Elsa Avila Arreguin,Maryam Banikazemi,Marta Dragosky,Marcelo Iastrebner,Hanna Rosenbaum,Mici Phillips,Gregory M. Pastores,Daniel I. Rosenthal,Mathilde Kaper,Tejdip Singh,Ana Cristina Puga,Peter L. Bonate,M. Judith Peterschmitt
Platelets and Thrombopoiesis
Thrombosis and Hemostasis
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis
Robert Silasi-Mansat,Hua Zhu,Narcis I. Popescu,Glenn Peer,Georgia Sfyroera,Paola Magotti,Lacramioara Ivanciu,Cristina Lupu,Tom E. Mollnes,Fletcher B. Taylor,Gary Kinasewitz,John D. Lambris,Florea Lupu
Vascular Biology
Correspondence
Poor outcome after reintroduction of imatinib in patients with chronic myeloid leukemia who interrupt therapy on account of pregnancy without having achieved an optimal response
Aya Kuwabara,Anna Babb,Amr Ibrahim,Dragana Milojkovic,Jane Apperley,Marco Bua,Alistair Reid,Letizia Foroni,Katayoun Rezvani,John Goldman,David Marin
Errata
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Cover Image
Cover Image
![issue cover]()
Visualization of T-cell extravasation into lymphoid tissue. The image shows an immunofluorescent section of transmigrated T cells (red) entering a mouse peripheral lymph node through high endothelial venules (HEVs; pink) shortly after adoptive transfer. Transferred cells are in close proximity to the laminin-positive basement membrane (blue) surrounding HEVs. The observed perivascular entrapment of transferred T cells is consistent with a transient decrease in T-cell motility shortly after transmigration as observed via dynamic twophoton microscopy imaging. See the article by Boscacci et al on page 915.
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