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Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson
Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene
Issue Archive
April 25 2013
In this Issue
Table of Contents
Inside Blood
Blood Work
Plenary Paper
Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100
Franziska Leonhardt,Sebastian Grundmann,Martin Behe,Franziska Bluhm,Rebecca A. Dumont,Friederike Braun,Melpomeni Fani,Katarina Riesner,Gabriele Prinz,Anne-Kathrin Hechinger,Ulrike V. Gerlach,Heide Dierbach,Olaf Penack,Annette Schmitt-Gräff,Jürgen Finke,Wolfgang A. Weber,Robert Zeiser
Review Article
Evidence-Based Focused Review
Clinical Trials and Observations
Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson
Clinical Trials & Observations
Joshua J. Field,Gene Lin,Maureen M. Okam,Elaine Majerus,Jeffrey Keefer,Onyinye Onyekwere,Ainsley Ross,Federico Campigotto,Donna Neuberg,Joel Linden,David G. Nathan
Gene Therapy
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant
Jenny McIntosh,Peter J. Lenting,Cecilia Rosales,Doyoung Lee,Samira Rabbanian,Deepak Raj,Nishil Patel,Edward G. D. Tuddenham,Olivier D. Christophe,John H. McVey,Simon Waddington,Arthur W. Nienhuis,John T. Gray,Paolo Fagone,Federico Mingozzi,Shang-Zhen Zhou,Katherine A. High,Maria Cancio,Catherine Y. C. Ng,Junfang Zhou,Christopher L. Morton,Andrew M. Davidoff,Amit C. Nathwani
Hematopoiesis and Stem Cells
Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis
Maria Zingariello,Fabrizio Martelli,Fiorella Ciaffoni,Francesca Masiello,Barbara Ghinassi,Emanuela D’Amore,Margherita Massa,Giovanni Barosi,Laura Sancillo,Xiaochun Li,Judith D. Goldberg,Rosa Alba Rana,Anna Rita Migliaccio
Immunobiology
IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans
Nathalie Schmitt,Jacinta Bustamante,Laure Bourdery,Salah Eddine Bentebibel,Stephanie Boisson-Dupuis,Fran Hamlin,Mau V. Tran,Derek Blankenship,Virginia Pascual,Daniel A. Savino,Jacques Banchereau,Jean-Laurent Casanova,Hideki Ueno
Lymphoid Neoplasia
Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells
Brian A. Walker,Christopher P. Wardell,David C. Johnson,Martin F. Kaiser,Dil B. Begum,Nasrin B. Dahir,Fiona M. Ross,Faith E. Davies,David Gonzalez,Gareth J. Morgan
A European collaborative study of treatment outcomes in 346 patients with cardiac stage III AL amyloidosis
Ashutosh D. Wechalekar,Stefan O. Schonland,Efstathios Kastritis,Julian D. Gillmore,Meletios A. Dimopoulos,Thirusha Lane,Andrea Foli,Darren Foard,Paolo Milani,Lisa Rannigan,Ute Hegenbart,Philip N. Hawkins,Giampaolo Merlini,Giovanni Palladini
Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene
Brief Report
Silva Saarinen,Eevi Kaasinen,Marja-Liisa Karjalainen-Lindsberg,Kari Vesanen,Mervi Aavikko,Riku Katainen,Minna Taskinen,Soili Kytölä,Sirpa Leppä,Marja Hietala,Pia Vahteristo,Lauri A. Aaltonen
Myeloid Neoplasia
RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes
Yuka Harada,Daichi Inoue,Ye Ding,Jun Imagawa,Noriko Doki,Hirotaka Matsui,Takashi Yahata,Hiromichi Matsushita,Kiyoshi Ando,Goro Sashida,Atsushi Iwama,Toshio Kitamura,Hironori Harada
The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model
Paolo Sportoletti,Emanuela Varasano,Roberta Rossi,Oxana Bereshchenko,Debora Cecchini,Ilaria Gionfriddo,Niccolò Bolli,Enrico Tiacci,Tamara Intermesoli,Pamela Zanghì,Arianna Masciulli,Maria Paola Martelli,Franca Falzetti,Massimo F. Martelli,Brunangelo Falini
A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance
Fabio Santoro,Oronza A. Botrugno,Roberto Dal Zuffo,Isabella Pallavicini,Geoffrey M. Matthews,Leonie Cluse,Iros Barozzi,Silvia Senese,Lorenzo Fornasari,Simona Moretti,Lucia Altucci,Pier Giuseppe Pelicci,Susanna Chiocca,Ricky W. Johnstone,Saverio Minucci
Phagocytes, Granulocytes, and Myelopoiesis
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Thrombosis and Hemostasis
Transplantation
Promoting regulation via the inhibition of DNAM-1 after transplantation
Motoko Koyama,Rachel D. Kuns,Stuart D. Olver,Katie E. Lineburg,Mary Lor,Bianca E. Teal,Neil C. Raffelt,Lucie Leveque,Christopher J. Chan,Renee J. Robb,Kate A. Markey,Kylie A. Alexander,Antiopi Varelias,Andrew D. Clouston,Mark J. Smyth,Kelli P. A. MacDonald,Geoffrey R. Hill
Vascular Biology
A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing
Apurva V. Shirodkar,Rosanne St. Bernard,Anna Gavryushova,Anna Kop,Britta J. Knight,Matthew Shu-Ching Yan,Hon-Sum Jeffrey Man,Maneesh Sud,Robert P. Hebbel,Peter Oettgen,William C. Aird,Philip A. Marsden
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Cover Image
Cover Image
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Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson. Cover art by Minou Modabber, Director, DFCI Medical Arts Core. Photomicrograph provided by David M. Dorfman, MD, PhD, Department of Pathology, Brigham and Women's Hospital. See the article by Field et al on page 3329.
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