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Issue Archive

Volume 124, Issue 12
September 18 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
In vitro platelets in sight
Simon Stritt,Bernhard Nieswandt
View Articletitled, In vitro platelets in sight
INSIDE BLOOD COMMENTARY
Unexplained bleeding: another player to look out for!
Helen Philippou
View Articletitled, Unexplained bleeding: another player to look out for!
INSIDE BLOOD COMMENTARY
Oral anticoagulants: new and improved
Gary E. Raskob
View Articletitled, Oral anticoagulants: new and improved
INSIDE BLOOD COMMENTARY
Bringing out the DCs’ softer side in GVHD
William J. Murphy
View Articletitled, Bringing out the DCs’ softer side in GVHD
INSIDE BLOOD COMMENTARY
In utero transplantation may soon be in delivery
George E. Georges
View Articletitled, In utero transplantation may soon be in delivery

PLENARY PAPER

Platelet bioreactor-on-a-chip
Jonathan N. Thon,Linas Mazutis,Stephen Wu,Joanna L. Sylman,Allen Ehrlicher,Kellie R. Machlus,Qiang Feng,Shijiang Lu,Robert Lanza,Keith B. Neeves,David A. Weitz,Joseph E. Italiano, Jr
View Articletitled, Platelet bioreactor-on-a-chip
Supplemental data

BLOOD SPOTLIGHT

Spotlight on pathogenesis of TRALI: HNA-3a (CTL2) antibodies
CME
Emily K. Storch,Christopher D. Hillyer,Beth H. Shaz
View Articletitled, Spotlight on pathogenesis of TRALI: HNA-3a (CTL2) antibodies

REVIEW ARTICLE

The Tao of myeloma
Lawrence H. Boise,Jonathan L. Kaufman,Nizar J. Bahlis,Sagar Lonial,Kelvin P. Lee
View Articletitled, The Tao of myeloma

CLINICAL TRIALS AND OBSERVATIONS

In adults with t(8;21)AML, posttransplant RUNX1/RUNX1T1-based MRD monitoring, rather than c-KIT mutations, allows further risk stratification
Clinical Trials & Observations
Yu Wang,De-Pei Wu,Qi-Fa Liu,Ya-Zhen Qin,Jing-Bo Wang,Lan-Ping Xu,Yan-Rong Liu,Hong-Hu Zhu,Jia Chen,Min Dai,Xiao-Jun Huang
View Articletitled, In adults with t(8;21)AML, posttransplant <em>RUNX1/RUNX1T1</em>-based MRD monitoring, rather than c-KIT mutations, allows further risk stratification
GEM2005 trial update comparing VMP/VTP as induction in elderly multiple myeloma patients: do we still need alkylators?
Clinical Trials & Observations
María-Victoria Mateos,Albert Oriol,Joaquín Martínez-López,Ana-Isabel Teruel,Ana López de la Guía,Javier López,Enrique Bengoechea,Montserrat Pérez,Rafael Martínez,Luis Palomera,Felipe de Arriba,Yolanda González,José Mariano Hernández,Miquel Granell,José-Luis Bello,Joan Bargay,Francisco-Javier Peñalver,María-Luisa Martín-Mateos,Bruno Paiva,María-Angeles Montalbán,Joan Bladé,Juan-Jose Lahuerta,Jesús F. San-Miguel
View Articletitled, GEM2005 trial update comparing VMP/VTP as induction in elderly multiple myeloma patients: do we still need alkylators?

IMMUNOBIOLOGY

Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108E mutation
Sandra Salem,David Langlais,François Lefebvre,Guillaume Bourque,Venetia Bigley,Muzz Haniffa,Jean-Laurent Casanova,David Burk,Albert Berghuis,Karina M. Butler,Timothy Ronan Leahy,Sophie Hambleton,Philippe Gros
View Articletitled, Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8<sup>K108E</sup> mutation
Supplemental data

LYMPHOID NEOPLASIA

CXCR7-dependent angiogenic mononuclear cell trafficking regulates tumor progression in multiple myeloma
Abdel Kareem Azab,Ilyas Sahin,Feda Azab,Michele Moschetta,Yuji Mishima,Nicholas Burwick,Johann Zimmermann,Barbara Romagnoli,Kalpana Patel,Eric Chevalier,Aldo M. Roccaro,Irene M. Ghobrial
View Articletitled, CXCR7-dependent angiogenic mononuclear cell trafficking regulates tumor progression in multiple myeloma
Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma
Jagadish Kummetha Venkata,Ningfei An,Robert Stuart,Luciano J. Costa,Houjian Cai,Woodrow Coker,Jin H. Song,Kiwana Gibbs,Terri Matson,Elizabeth Garrett-Mayer,Zhuang Wan,Besim Ogretmen,Charles Smith,Yubin Kang
View Articletitled, Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma
Supplemental data

PLATELETS AND THROMBOPOIESIS

Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects
Brief Report
Jon P. Connelly,Erika M. Kwon,Yongxing Gao,Niraj S. Trivedi,Abdel G. Elkahloun,Marshall S. Horwitz,Linzhao Cheng,P. Paul Liu
View Articletitled, Targeted correction of <em>RUNX1</em> mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation
Shilpa M. Hattangadi,Sandra Martinez-Morilla,Heide Christine Patterson,Jiahai Shi,Karly Burke,Amalia Avila-Figueroa,Srividhya Venkatesan,Junxia Wang,Katharina Paulsen,Dirk Görlich,Maki Murata-Hori,Harvey F. Lodish
View Articletitled, Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation
Supplemental data
Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD
Anthony O. Awojoodu,Philip M. Keegan,Alicia R. Lane,Yuying Zhang,Kevin R. Lynch,Manu O. Platt,Edward A. Botchwey
View Articletitled, Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD
Supplemental data

THROMBOSIS AND HEMOSTASIS

A hereditary bleeding disorder resulting from a premature stop codon in thrombomodulin (p.Cys537Stop)
Jonathan Langdown,Roger J. Luddington,James A. Huntington,Trevor P. Baglin
View Articletitled, A hereditary bleeding disorder resulting from a premature stop codon in thrombomodulin (p.Cys537Stop)
Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism
Michael Keegan Delaney,Junling Liu,Kyungho Kim,Bo Shen,Aleksandra Stojanovic-Terpo,Yi Zheng,Jaehyung Cho,Xiaoping Du
View Articletitled, Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism
Supplemental data
Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials
Clinical Trials & Observations
Nick van Es,Michiel Coppens,Sam Schulman,Saskia Middeldorp,Harry R. Büller
View Articletitled, Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials
Supplemental data

TRANSPLANTATION

Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD
Christian M. Capitini,Nicole M. Nasholm,Christopher D. Chien,Shannon M. Larabee,Haiying Qin,Young K. Song,Peter J. Klover,Lothar Hennighausen,Javed Khan,Terry J. Fry
View Articletitled, Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD
Supplemental data
Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation
Jesse D. Vrecenak,Erik G. Pearson,Matthew T. Santore,Carlyn A. Todorow,Haiying Li,Antoneta Radu,Tricia Bhatti,William H. Peranteau,Mark P. Johnson,Alan W. Flake
View Articletitled, Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation
Supplemental data

BLOOD WORK

Uveal melanoma with diffuse bone marrow involvement
Sheng-Yen Hsiao,Tsai-Yun Chen
View Articletitled, Uveal melanoma with diffuse bone marrow involvement
Functional hyposplenism diagnosed by blood film examination
Muhajir Mohamed
View Articletitled, Functional hyposplenism diagnosed by blood film examination

CORRESPONDENCE

Arsenic trioxide and mannitol for the treatment of acute promyelocytic leukemia relapse in the central nervous system
Clinical Trials & Observations
Hong Wang,Fenglin Cao,Jinmei Li,Limin Li,Yong Li,Ce Shi,Wenjia Lan,Dandan Li,Hui Zhao,Ying Zhang,Zhuo Zhang,Xiuhua Liu,Ran Meng,Baofeng Yang,Jin Zhou
View Articletitled, Arsenic trioxide and mannitol for the treatment of acute promyelocytic leukemia relapse in the central nervous system
Second primary malignancies in adult acute lymphoblastic leukemia: a US population–based study
Clinical Trials & Observations
Krishna Bilas Ghimire,Binay Kumar Shah
View Articletitled, Second primary malignancies in adult acute lymphoblastic leukemia: a US population–based study
Genome-wide scan identifies variant in 2q12.3 associated with risk for multiple myeloma
Stephen W. Erickson,Vinay R. Raj,Owen W. Stephens,Ishwori Dhakal,Shweta S. Chavan,Naveen Sanathkumar,Elizabeth Ann Coleman,Jeannette Y. Lee,Julia A. Goodwin,Senu Apewokin,Daohong Zhou,Joshua Epstein,Christoph J. Heuck,Annette J. Vangsted
View Articletitled, Genome-wide scan identifies variant in 2q12.3 associated with risk for multiple myeloma
Supplemental data

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

TRALI: human neutrophil antigens and antibodies
CME
View Articletitled, TRALI: human neutrophil antigens and antibodies
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