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Issue Archive

Volume 113, Issue 5
January 29 2009
Issue Cover

Table of Contents

INSIDE BLOOD

PLATELETS & THROMBOPOIESIS
Megakaryocyte-derived microvesicles, please stand up!
Mariusz Z. Ratajczak
View Articletitled, Megakaryocyte-derived microvesicles, please stand up!
TRANSPLANTATION
Bone marrow cells can manipulate healing
Vincent Falanga
View Articletitled, Bone marrow cells can manipulate healing
VASCULAR BIOLOGY
The hunting of the Snrk
Jack L. Arbiser,Levi Fried
View Articletitled, The hunting of the Snrk

HOW I TREAT

How we diagnose the antiphospholipid syndrome
Bill Giannakopoulos,Freda Passam,Yiannis Ioannou,Steven A. Krilis
View Articletitled, How we diagnose the antiphospholipid syndrome

CLINICAL TRIALS AND OBSERVATIONS

High-dose therapy followed by autologous purged stem cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by the GOELAMS with final results after a median follow-up of 9 years
Clinical Trials & Observations
Emmanuel Gyan,Charles Foussard,Philippe Bertrand,Patrick Michenet,Steven Le Gouill,Christian Berthou,Hervé Maisonneuve,Vincent Delwail,Rémi Gressin,Philippe Quittet,Jean-Pierre Vilque,Bernard Desablens,Jérôme Jaubert,Jean-François Ramée,Nina Arakelyan,Antoine Thyss,Cécile Moluçon-Chabrot,Roselyne Delépine,Noël Milpied,Philippe Colombat,Eric Deconinck,for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS),for the Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS)
View Articletitled, High-dose therapy followed by autologous purged stem cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by the GOELAMS with final results after a median follow-up of 9 years
Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13
Brief Report
Todd A. Fehniger,John C. Byrd,Guido Marcucci,Camille N. Abboud,Cheryl Kefauver,Jacqueline E. Payton,Ravi Vij,William Blum
View Articletitled, Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13

GENE THERAPY

IL-7 and IL-15 allow the generation of suicide gene–modified alloreactive self-renewing central memory human T lymphocytes
Shin Kaneko,Sara Mastaglio,Attilio Bondanza,Maurilio Ponzoni,Francesca Sanvito,Luca Aldrighetti,Marina Radrizzani,Simona La Seta-Catamancio,Elena Provasi,Anna Mondino,Toshiro Nagasawa,Katharina Fleischhauer,Vincenzo Russo,Catia Traversari,Fabio Ciceri,Claudio Bordignon,Chiara Bonini
View Articletitled, IL-7 and IL-15 allow the generation of suicide gene–modified alloreactive self-renewing central memory human T lymphocytes

HEMATOPOIESIS AND STEM CELLS

Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions
Shawn W. Cochrane,Ying Zhao,Robert S. Welner,Xiao-Hong Sun
View Articletitled, Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions
Supplemental data
SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription
Hideaki Nakajima,Toshiki Tamura,Miyuki Ito,Fumi Shibata,Kana Kuroda,Yumi Fukuchi,Naohide Watanabe,Toshio Kitamura,Yasuo Ikeda,Makoto Handa
View Articletitled, SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription
Supplemental data

IMMUNOBIOLOGY

Critical role of class IA PI3K for c-Rel expression in B lymphocytes
Satoshi Matsuda,Yohei Mikami,Masashi Ohtani,Mari Fujiwara,Yasuko Hirata,Akiko Minowa,Yasuo Terauchi,Takashi Kadowaki,Shigeo Koyasu
View Articletitled, Critical role of class IA PI3K for c-Rel expression in B lymphocytes
Supplemental data
Hematopoietic cell–derived interferon controls viral replication and virus-induced disease
Philipp A. Lang,Luisa Cervantes-Barragan,Admar Verschoor,Alexander A. Navarini,Mike Recher,Marc Pellegrini,Lukas Flatz,Andreas Bergthaler,Kenya Honda,Burkhard Ludewig,Pamela S. Ohashi,Karl S. Lang
View Articletitled, Hematopoietic cell–derived interferon controls viral replication and virus-induced disease
Supplemental data

LYMPHOID NEOPLASIA

A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36
Tiemo Katzenberger,Jörg Kalla,Ellen Leich,Heike Stöcklein,Elena Hartmann,Sandra Barnickel,Swen Wessendorf,M. Michaela Ott,Hans Konrad Müller-Hermelink,Andreas Rosenwald,German Ott
View Articletitled, A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36
Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody
David M. Goldenberg,Edmund A. Rossi,Rhona Stein,Thomas M. Cardillo,Myron S. Czuczman,Francisco J. Hernandez-Ilizaliturri,Hans J. Hansen,Chien-Hsing Chang
View Articletitled, Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody
Supplemental data
Gene expression profiling of peripheral T-cell lymphoma including γδ T-cell lymphoma
Brief Report
Kana Miyazaki,Motoko Yamaguchi,Hiroshi Imai,Tohru Kobayashi,Satoshi Tamaru,Kazuhiro Nishii,Masao Yuda,Hiroshi Shiku,Naoyuki Katayama
View Articletitled, Gene expression profiling of peripheral T-cell lymphoma including γδ T-cell lymphoma
Supplemental data

MYELOID NEOPLASIA

A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene
Bin Yin,Ruud Delwel,Peter J. Valk,Margaret R. Wallace,Mignon L. Loh,Kevin M. Shannon,David A. Largaespada
View Articletitled, A retroviral mutagenesis screen reveals strong cooperation between <em>Bcl11a</em> overexpression and loss of the <em>Nf1</em> tumor suppressor gene
Supplemental data
RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia
Won-Il Kim,Ilze Matise,Miechaleen D. Diers,David A. Largaespada
View Articletitled, <em>RAS</em> oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

STIM1 is essential for Fcγ receptor activation and autoimmune inflammation
Attila Braun,J. Engelbert Gessner,David Varga-Szabo,Shahzad N. Syed,Stephanie Konrad,David Stegner,Timo Vögtle,Reinhold E. Schmidt,Bernhard Nieswandt
View Articletitled, STIM1 is essential for Fcγ receptor activation and autoimmune inflammation
Supplemental data

PLATELETS AND THROMBOPOIESIS

Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia
Daniel W. Bougie,Jessica Birenbaum,Mark Rasmussen,Mortimer Poncz,Richard H. Aster
View Articletitled, Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia
Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles
Robert Flaumenhaft,James R. Dilks,Jennifer Richardson,Eva Alden,Sunita R. Patel-Hett,Elisabeth Battinelli,Giannoula L. Klement,Martha Sola-Visner,Joseph E. Italiano, Jr
View Articletitled, Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease
Susan Yuditskaya,Ashaunta Tumblin,Gerard T. Hoehn,Guanghui Wang,Steven K. Drake,Xiuli Xu,Saixia Ying,Amy H. Chi,Alan T. Remaley,Rong-Fong Shen,Peter J. Munson,Anthony F. Suffredini,Gregory J. Kato
View Articletitled, Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease
Supplemental data
Placenta growth factor induces 5-lipoxygenase–activating protein to increase leukotriene formation in sickle cell disease
Nitin Patel,Caryn S. Gonsalves,Minyang Yang,Punam Malik,Vijay K. Kalra
View Articletitled, Placenta growth factor induces 5-lipoxygenase–activating protein to increase leukotriene formation in sickle cell disease
Supplemental data

THROMBOSIS AND HEMOSTASIS

Proteolytic inactivation of tissue factor pathway inhibitor by bacterial omptins
Thomas H. Yun,Jessica E. Cott,Richard I. Tapping,James M. Slauch,James H. Morrissey
View Articletitled, Proteolytic inactivation of tissue factor pathway inhibitor by bacterial omptins
Supplemental data
A functional calcium-binding site in the metalloprotease domain of ADAMTS13
Michelle D. Gardner,Chan K. N. K. Chion,Rens de Groot,Anuja Shah,James T. B. Crawley,David A. Lane
View Articletitled, A functional calcium-binding site in the metalloprotease domain of ADAMTS13

TRANSFUSION MEDICINE

Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation
Nilam S. Mangalmurti,Zeyu Xiong,Mei Hulver,Mrunalini Ranganathan,Xiang Hong Liu,Timothy Oriss,Meghan Fitzpatrick,Marc Rubin,Darrell Triulzi,Augustine Choi,Janet S. Lee
View Articletitled, Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation
Supplemental data

TRANSPLANTATION

Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells
Jakub Tolar,Akemi Ishida-Yamamoto,Megan Riddle,Ron T. McElmurry,Mark Osborn,Lily Xia,Troy Lund,Catherine Slattery,Jouni Uitto,Angela M. Christiano,John E. Wagner,Bruce R. Blazar
View Articletitled, Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells
Solid cancers after allogeneic hematopoietic cell transplantation
J. Douglas Rizzo,Rochelle E. Curtis,Gérard Socié,Kathleen A. Sobocinski,Ethel Gilbert,Ola Landgren,Lois B. Travis,William D. Travis,Mary E. D. Flowers,Debra L. Friedman,Mary M. Horowitz,John R. Wingard,H. Joachim Deeg
View Articletitled, Solid cancers after allogeneic hematopoietic cell transplantation

VASCULAR BIOLOGY

Dusp-5 and Snrk-1 coordinately function during vascular development and disease
Kallal Pramanik,Chang Zoon Chun,Maija K. Garnaas,Ganesh V. Samant,Keguo Li,Mark A. Horswill,Paula E. North,Ramani Ramchandran
View Articletitled, Dusp-5 and Snrk-1 coordinately function during vascular development and disease
Supplemental data
Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates
Chang Z. Chun,Sukhbir Kaur,Ganesh V. Samant,Ling Wang,Kallal Pramanik,Maija K. Garnaas,Keguo Li,Lyndsay Field,Debabrata Mukhopadhyay,Ramani Ramchandran
View Articletitled, <em>Snrk-1</em> is involved in multiple steps of angioblast development and acts via <em>notch</em> signaling pathway in artery-vein specification in vertebrates
Supplemental data

CORRESPONDENCE

Trisomy 13: prevalence and clinicopathologic correlates of another potentially lenalidomide-sensitive cytogenetic abnormality
Ruben A. Mesa,Curtis A. Hanson,Rhett P. Ketterling,Susan Schwager,Ryan A. Knudson,Ayalew Tefferi
View Articletitled, Trisomy 13: prevalence and clinicopathologic correlates of another potentially lenalidomide-sensitive cytogenetic abnormality
Intravenous administration of mesenchymal stem cells genetically modified with extracellular superoxide dismutase improves survival in irradiated mice
Aly S. Abdel-Mageed,Anthony J. Senagore,Daniel W. Pietryga,Robert H. Connors,Troy A. Giambernardi,Rick V. Hay,Weiwen Deng
View Articletitled, Intravenous administration of mesenchymal stem cells genetically modified with extracellular superoxide dismutase improves survival in irradiated mice
Elevated expression of the leukemia-associated antigen SSX2IP predicts survival in acute myeloid leukemia patients who lack detectable cytogenetic rearrangements
Barbara Guinn,Jochen Greiner,Michael Schmitt,Ken I. Mills
View Articletitled, Elevated expression of the leukemia-associated antigen SSX2IP predicts survival in acute myeloid leukemia patients who lack detectable cytogenetic rearrangements
B cells versus T cells as primary barrier to hematopoietic engraftment in allosensitized recipients
Rainer Storb
View Articletitled, B cells versus T cells as primary barrier to hematopoietic engraftment in allosensitized recipients
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