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Issue Archive

Volume 99, Issue 12
June 15 2002
Blood Cover Image for Volume 99, Issue 12

Table of Contents

INSIDE BLOOD

Cure of childhood ALL: exacting a lower toll
Ching-Hon Pui
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PLENARY PAPERS

Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983
Clinical Trials & Observations
Smita Bhatia,Harland N. Sather,Olga B. Pabustan,Michael E. Trigg,Paul S. Gaynon,Leslie L. Robison
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PERSPECTIVE

Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation
James J. Biagi,John F. Seymour
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REVIEW ARTICLES

Autologous stem cell transplantation for primary systemic amyloidosis
Clinical Trials & Observations
Raymond L. Comenzo,Morie A. Gertz
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The role of cytokines in classical Hodgkin lymphoma
Brian F. Skinnider,Tak W. Mak
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CHEMOKINES

Cholesterol is essential for macrophage inflammatory protein 1β binding and conformational integrity of CC chemokine receptor 5
Dzung H. Nguyen,Dennis Taub
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Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines
Younghee Lee,Akihiko Gotoh,Hyung-Joo Kwon,Minute You,Lisa Kohli,Charlie Mantel,Scott Cooper,Giao Hangoc,Keisuke Miyazawa,Kazuma Ohyashiki,Hal E. Broxmeyer
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Lck is required for stromal cell–derived factor 1α (CXCL12)–induced lymphoid cell chemotaxis
Marit Inngjerdingen,Knut Martin Torgersen,Azzam A. Maghazachi
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis: Presented in part at the 42nd Annual Meeting of the American Society of Hematology, December 1-5, 2000, San Francisco, CA (abstract 2334).
Clinical Trials & Observations
Christian Thiede,Christine Steudel,Brigitte Mohr,Markus Schaich,Ulrike Schäkel,Uwe Platzbecker,Martin Wermke,Martin Bornhäuser,Markus Ritter,Andreas Neubauer,Gerhard Ehninger,Thomas Illmer
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Ibritumomab tiuxetan radioimmunotherapy for patients with relapsed or refractory non-Hodgkin lymphoma and mild thrombocytopenia: a phase II multicenter trial
Clinical Trials & Observations
Gregory A. Wiseman,Leo I. Gordon,Pratik S. Multani,Thomas E. Witzig,Stewart Spies,Nancy L. Bartlett,Russell J. Schilder,James L. Murray,Mansoor Saleh,Roberta S. Allen,Antonio J. Grillo-López,Christine A. White
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Gemtuzumab ozogamicin with or without interleukin 11 in patients 65 years of age or older with untreated acute myeloid leukemia and high-risk myelodysplastic syndrome: comparison with idarubicin plus continuous-infusion, high-dose cytosine arabinoside
Clinical Trials & Observations
Elihu H. Estey,Peter F. Thall,Francis J. Giles,Xue-Mei Wang,Jorge E. Cortes,Miloslav Beran,Sherry A. Pierce,Deborah A. Thomas,Hagop M. Kantarjian
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Unrelated donor bone marrow transplantation for thalassemia: the effect of extended haplotypes
Clinical Trials & Observations
Giorgio La Nasa,Claudio Giardini,Francesca Argiolu,Franco Locatelli,Marcella Arras,Piero De Stefano,Antonio Ledda,Antonella Pizzati,Maria A. Sanna,Adriana Vacca,Guido Lucarelli,Licinio Contu
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High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution
Clinical Trials & Observations
Suparno Chakrabarti,Stephen Mackinnon,Raj Chopra,Panagiotis D. Kottaridis,Karl Peggs,Peter O'Gorman,Ronjon Chakraverty,Timothy Marshall,Husam Osman,Premini Mahendra,Charles Craddock,Herman Waldmann,Geoff Hale,Christopher D. Fegan,Kwee Yong,Anthony H. Goldstone,David C. Linch,Donald W. Milligan
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Prevention of Epstein-Barr virus–lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation
Clinical Trials & Observations
Joost W. J. van Esser,Hubert G. M. Niesters,Bronno van der Holt,Ellen Meijer,Albert D. M. E. Osterhaus,Jan Willem Gratama,Leo F. Verdonck,Bob Löwenberg,Jan J. Cornelissen
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Retrospective comparison of bone marrow and granulocyte colony-stimulating factor–mobilized peripheral blood progenitor cells for allogeneic stem cell transplantation using HLA identical sibling donors in myelodysplastic syndromes
Clinical Trials & Observations
Philippe Guardiola,Volker Runde,Andrea Bacigalupo,Tapani Ruutu,Franco Locatelli,Marc A. Boogaerts,Antonio Pagliuca,Jan J. Cornelissen,Harry C. Schouten,Enric Carreras,Jürgen Finke,Anja van Biezen,Ronald Brand,Dietger Niederwieser,Eliane Gluckman,Theo M. de Witte,for the subcommittee for Myelodysplastic Syndromes of the Chronic Leukaemia Working Party of the European Blood and Marrow Transplantation Group
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Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia
Clinical Trials & Observations
Dieter Hoelzer,Nicola Gökbuget,Werner Digel,Thomas Faak,Michael Kneba,Regina Reutzel,Joanna Romejko-Jarosinska,Jacek Zwolinski,Jan Walewski,for the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia
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Detection of minimal residual disease identifies differences in treatment response between T-ALL and precursor B-ALL
Clinical Trials & Observations
Marja J. Willemse,Taku Seriu,Klaudia Hettinger,Elisabetta d'Aniello,Wim C. J. Hop,E. Renate Panzer-Grümayer,Andrea Biondi,Martin Schrappe,Willem A. Kamps,Guiseppe Masera,Helmut Gadner,Hansjoerg Riehm,Claus R. Bartram,Jacques J. M. van Dongen
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GENE THERAPY

Induction of T-cell tolerance to an MHC class I alloantigen by gene therapy
Jessamyn Bagley,Chaorui Tian,David H. Sachs,John Iacomini
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HEMATOPOIESIS

Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesis
Suzanne Burns,Murat O. Arcasoy,Li Li,Elizabeth Kurian,Katri Selander,Peter D. Emanuel,Kevin W. Harris
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Induction of granulocytic differentiation by 2 pathways
Pu Zhang,Erik Nelson,Hanna S. Radomska,Junko Iwasaki-Arai,Koichi Akashi,Alan D. Friedman,Daniel G. Tenen
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c-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors
Naoyuki Anzai,Younghee Lee,Byung-S. Youn,Seiji Fukuda,Young-June Kim,Charlie Mantel,Makoto Akashi,Hal E. Broxmeyer
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Site-directed mutagenesis of platelet glycoprotein Ibα demonstrating residues involved in the sulfation of tyrosines 276, 278, and 279
A. Sasha Tait,Jing-Fei Dong,José A. López,Ian W. Dawes,Beng H. Chong
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The cysteine knot of platelet glycoprotein Ibβ (GPIbβ) is critical for the interaction of GPIbβ with GPIX
Dermot Kenny,Patricia A. Morateck,Robert R. Montgomery
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Adenovirus encoding vascular endothelial growth factor–D induces tissue-specific vascular patterns in vivo
Tatiana V. Byzova,Corey K. Goldman,Jurek Jankau,Juhua Chen,Gustavo Cabrera,Marc G. Achen,Steven A. Stacker,Kevin A. Carnevale,Maria Siemionow,Steven R. Deitcher,Paul E. DiCorleto
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Supplemental data
Heme oxygenase-1–derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth
Kelly J. Peyton,Sylvia V. Reyna,Gary B. Chapman,Diana Ensenat,Xiao-ming Liu,Hong Wang,Andrew I. Schafer,William Durante
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A new platelet polymorphism Duva+, localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia
Vincent Jallu,Marc Meunier,Maryline Brément,Cécile Kaplan
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Identification of integrin αMβ2 as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions
Joseph M. Schober,Ningyu Chen,Tatiana M. Grzeszkiewicz,Igor Jovanovic,Eugene E. Emeson,Tatiana P. Ugarova,Richard D. Ye,Lester F. Lau,Stephen C.-T. Lam
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Arp2/3 complex is required for actin polymerization during platelet shape change
Zhi Li,Eric S. Kim,Elaine L. Bearer
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Intrinsic pathway of blood coagulation contributes to thrombogenicity of atherosclerotic plaque
Natalya M. Ananyeva,Diana V. Kouiavskaia,Midori Shima,Evgueni L. Saenko
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Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia
Gregor Theilmeier,Carine Michiels,Erik Spaepen,Ingrid Vreys,Désiré Collen,Jos Vermylen,Marc F. Hoylaerts
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Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin
Karen R. Snapp,Christine E. Heitzig,Geoffrey S. Kansas
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IMMUNOBIOLOGY

Effect of DNA methylation and chromatin structure onITGAL expression
Qianjin Lu,Donna Ray,David Gutsch,Bruce Richardson
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The lymphoproliferative defect in CTLA-4–deficient mice is ameliorated by an inhibitory NK cell receptor
Cynthia A. Chambers,Joonsoo Kang,Yongjian Wu,Werner Held,David H. Raulet,James P. Allison
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Effect of rapamycin on the cyclosporin A–resistant CD28-mediated costimulatory pathway
Paritosh Ghosh,Meredith A. Buchholz,Shingo Yano,Dennis Taub,Dan L. Longo
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NEOPLASIA

Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications
Nicholas Mitsiades,Constantine S. Mitsiades,Vassiliki Poulaki,Dharminder Chauhan,Paul G. Richardson,Teru Hideshima,Nikhil C. Munshi,Steven P. Treon,Kenneth C. Anderson
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Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis
Malgorzata Nieborowska-Skorska,Grazyna Hoser,Plamen Kossev,Mariusz A. Wasik,Tomasz Skorski
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Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma
Rosita L. ten Berge,Chris J. L. M. Meijer,Danny F. Dukers,J. Alain Kummer,Bellinda A. Bladergroen,Wim Vos,C. Erik Hack,Gert J. Ossenkoppele,Joost J. Oudejans
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Derivative chromosome 9 deletions in chronic myeloid leukemia: poor prognosis is not associated with loss of ABL-BCRexpression, elevated BCR-ABL levels, or karyotypic instability
Brian J. P. Huntly,Anthony J. Bench,Eric Delabesse,Alistair G. Reid,Juan Li,Mike A. Scott,Lynda Campbell,Jennie Byrne,Eleanor Pinto,Andre Brizard,Deitger Niedermeiser,Elizabeth P. Nacheva,Francois Guilhot,Michael Deininger,Anthony R. Green
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Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes
Christian Korz,Armin Pscherer,Axel Benner,Daniel Mertens,Claudia Schaffner,Elke Leupolt,Hartmut Döhner,Stephan Stilgenbauer,Peter Lichter
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Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells
Mario Gonzalez-Gronow,Govind Gawdi,Salvatore V. Pizzo
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The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice
Ryan P. Million,Jon Aster,D. Gary Gilliland,Richard A. Van Etten
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PHAGOCYTES

Multiple PU.1 sites cooperate in the regulation ofp40phox transcription during granulocytic differentiation of myeloid cells
Sen-Lin Li,Anthony J. Valente,Mei Qiang,Werner Schlegel,Maria Gamez,Robert A. Clark
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TRANSFUSION MEDICINE

Age at infection affects the long-term outcome of transfusion-associated chronic hepatitis C
Eliseo Minola,Daniele Prati,Fredy Suter,Franco Maggiolo,Flavio Caprioli,Aurelio Sonzogni,Mirella Fraquelli,Silvia Paggi,Dario Conte
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TRANSPLANTATION

Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
Dullei Min,Patricia A. Taylor,Angela Panoskaltsis-Mortari,Brile Chung,Dimitry M. Danilenko,Catherine Farrell,David L. Lacey,Bruce R. Blazar,Kenneth I. Weinberg
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Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell
Patricia A. Taylor,Thea M. Friedman,Robert Korngold,Randolph J. Noelle,Bruce R. Blazar
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Immunologic effects of prophylactic donor lymphocyte infusion after allogeneic marrow transplantation for multiple myeloma
Roberto Bellucci,Edwin P. Alyea,Edie Weller,Antoinette Chillemi,Ephraim Hochberg,Catherine J. Wu,Christine Canning,Robert Schlossman,Robert J. Soiffer,Kenneth C. Anderson,Jerome Ritz
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Quantitative assessment of hematopoietic chimerism after bone marrow transplantation by real-time quantitative polymerase chain reaction
Mehdi Alizadeh,Marc Bernard,Bruno Danic,Charly Dauriac,Brigitte Birebent,Christine Lapart,Thierry Lamy,Pierre-Yves Le Prisé,Alain Beauplet,Dominique Bories,Gilbert Semana,Erwann Quelvennec
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BRIEF REPORTS

Correction of the murine Wiskott-Aldrich syndrome phenotype by hematopoietic stem cell transplantation
Brief Report
Ted S. Strom,Xiuling Li,John M. Cunningham,Arthur W. Nienhuis
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Deletion analysis of p16INKa and p15INKb in relapsed childhood acute lymphoblastic leukemia
Clinical Trials & Observations Brief Report
Hagen Graf Einsiedel,Tillmann Taube,Reinhard Hartmann,Sven Wellmann,Georg Seifert,Günter Henze,Karl Seeger
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Breaking the rules? X-ray examination of hematopoietic stem cell grafts at international airports
Brief Report
Andreas L. Petzer,Hans-Georg Speth,Elisabeth Hoflehner,Johannes Clausen,David Nachbaur,Günther Gastl,Eberhard Gunsilius
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Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors
Brief Report
Ugo Testa,Giovanni F. Torelli,Roberta Riccioni,Andrea Onetti Muta,Stefania Militi,Luciana Annino,Gualtiero Mariani,Anna Guarini,Sabina Chiaretti,Jerome Ritz,Franco Mandelli,Cesare Peschle,Robin Foa
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Narrowing and genomic annotation of the commonly deleted region of the 5q− syndrome
Brief Report
Jacqueline Boultwood,Carrie Fidler,Amanda J. Strickson,Fiona Watkins,Susana Gama,Lyndal Kearney,Sabrina Tosi,Arek Kasprzyk,Jan-Fang Cheng,Rina J. Jaju,James S. Wainscoat
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CORRESPONDENCE

Outcome of major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation may be influenced by conditioning regimen
Karl S. Peggs,Emma C. Morris,Panos D. Kottaridis,Joanne Geary,Anthony H. Goldstone,David C. Linch,Stephen Mackinnon
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Effects of adenosine 5′-diphosphate (ADP) receptor blockade on platelet aggregation under flow
Shinya Goto,Noriko Tamura,Shunnosuke Handa
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Immunocytochemistry reveals RANKL expression of myeloma cells
Orhan Sezer,Ulrike Heider,Christian Jakob,Ivana Zavrski,Jan Eucker,Kurt Possinger,Christine Sers,Veit Krenn
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Recurrent involvement of the MLL gene in adult T-lineage acute lymphoblastic leukemia
Sandrine Hayette,Isabelle Tigaud,Véronique Maguer-Satta,Laurent Bartholin,Xavier Thomas,Christiane Charrin,Mylène Gadoux,Jean-Pierre Magaud,Ruth Rimokh
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Implication for how the single nucleotide polymorphism (SNP) of Fc receptor, FcγRIIIa alters the interaction with anti-CD20 monoclonal antibody
Yasuo Oshima,Akio Fujimura
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All Issues

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