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Issue Archive

Volume 114, Issue 8
August 20 2009
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
Stem cells unscramble yolk sac hematopoiesis
Paul Gadue,Mitchell J. Weiss
View Articletitled, Stem cells unscramble yolk sac hematopoiesis
CLINICAL TRIALS
Finishing off fibrils
Morie Gertz
View Articletitled, Finishing off fibrils
IMMUNOBIOLOGY
Blocking PD-1 in cancer immunotherapy
Gianpietro Dotti
View Articletitled, Blocking PD-1 in cancer immunotherapy
MYELOID NEOPLASIA
Taking aim at protein translation in AML
Martin Carroll
View Articletitled, Taking aim at protein translation in AML
TRANSFUSION MEDICINE
A case of mistaken identity
Sergio Querol
View Articletitled, A case of mistaken identity

REVIEW ARTICLES

Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells
Thierry VandenDriessche,Zoltán Ivics,Zsuzsanna Izsvák,Marinee K. L. Chuah
View Articletitled, Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells

HOW I TREAT

How I treat mantle cell lymphoma
Michele Ghielmini,Emanuele Zucca
View Articletitled, How I treat mantle cell lymphoma

CLINICAL TRIALS AND OBSERVATIONS

Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele
Clinical Trials & Observations
Paola Guglielmelli,Giovanni Barosi,Giorgina Specchia,Alessandro Rambaldi,Francesco Lo Coco,Elisabetta Antonioli,Lisa Pieri,Alessandro Pancrazzi,Vanessa Ponziani,Federica Delaini,Giovanni Longo,Emanuele Ammatuna,Vincenzo Liso,Alberto Bosi,Tiziano Barbui,Alessandro M. Vannucchi
View Articletitled, Identification of patients with poorer survival in primary myelofibrosis based on the burden of <em>JAK2</em>V617F mutated allele
Risk of arterial cardiovascular events in patients after pulmonary embolism
Clinical Trials & Observations
Frederikus A. Klok,Inge C.M. Mos,Lisette Broek,Jouke T. Tamsma,Frits R. Rosendaal,Albert de Roos,Menno V. Huisman
View Articletitled, Risk of arterial cardiovascular events in patients after pulmonary embolism
Weekly and twice-weekly bortezomib in patients with systemic AL amyloidosis: results of a phase 1 dose-escalation study
Clinical Trials & Observations
Donna E. Reece,Vaishali Sanchorawala,Ute Hegenbart,Giampaolo Merlini,Giovanni Palladini,Jean-Paul Fermand,Robert A. Vescio,Xiangyang Liu,Yusri A. Elsayed,Andrew Cakana,Raymond L. Comenzo,for the VELCADE CAN2007 Study Group
View Articletitled, Weekly and twice-weekly bortezomib in patients with systemic AL amyloidosis: results of a phase 1 dose-escalation study
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis
Aleksandra Rizo,Sandra Olthof,Lina Han,Edo Vellenga,Gerald de Haan,Jan Jacob Schuringa
View Articletitled, Repression of BMI1 in normal and leukemic human CD34<sup>+</sup> cells impairs self-renewal and induces apoptosis
A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell–derived primitive hematopoiesis
Olena Klimchenko,Marcella Mori,Antonio DiStefano,Thierry Langlois,Frédéric Larbret,Yann Lecluse,Olivier Feraud,William Vainchenker,Françoise Norol,Najet Debili
View Articletitled, A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell–derived primitive hematopoiesis
Supplemental data

IMMUNOBIOLOGY

Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q
Mariko Yoshizaki,Aya Tazawa,Eiji Kasumi,Shigemi Sasawatari,Kenji Itoh,Taeko Dohi,Takehiko Sasazuki,Kayo Inaba,Andrew P. Makrigiannis,Noriko Toyama-Sorimachi
View Articletitled, Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q
Supplemental data
Programmed death 1 signaling on chronic myeloid leukemia–specific T cells results in T-cell exhaustion and disease progression
Sabine Mumprecht,Christian Schürch,Juerg Schwaller,Max Solenthaler,Adrian F. Ochsenbein
View Articletitled, Programmed death 1 signaling on chronic myeloid leukemia–specific T cells results in T-cell exhaustion and disease progression
Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
Mojgan Ahmadzadeh,Laura A. Johnson,Bianca Heemskerk,John R. Wunderlich,Mark E. Dudley,Donald E. White,Steven A. Rosenberg
View Articletitled, Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model
Long Zhang,Thomas F. Gajewski,Justin Kline
View Articletitled, PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model
Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response
Christof Geldmacher,Ian S. Metzler,Sodsai Tovanabutra,Tedi E. Asher,Emma Gostick,David R. Ambrozak,Constantinos Petrovas,Alexandra Schuetz,Njabulo Ngwenyama,Gustavo Kijak,Leonard Maboko,Michael Hoelscher,Francine McCutchan,David A. Price,Daniel C. Douek,Richard A. Koup
View Articletitled, Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response
Supplemental data

LYMPHOID NEOPLASIA

Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM
Roberto Alonso,Mónica López-Guerra,Ramanda Upshaw,Shanta Bantia,Caroline Smal,Françoise Bontemps,Chantal Manz,Thomas Mehrling,Neus Villamor,Elias Campo,Emili Montserrat,Dolors Colomer
View Articletitled, Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM
Supplemental data
Genetic fingerprinting of the development and progression of T-cell lymphoma in a murine model of atypical myeloproliferative disorder initiated by the ZNF198–fibroblast growth factor receptor-1 chimeric tyrosine kinase
Mingqiang Ren,Xiurong Li,John K. Cowell
View Articletitled, Genetic fingerprinting of the development and progression of T-cell lymphoma in a murine model of atypical myeloproliferative disorder initiated by the ZNF198–fibroblast growth factor receptor-1 chimeric tyrosine kinase
Supplemental data
The proteomic signature of NPM/ALK reveals deregulation of multiple cellular pathways
Megan S. Lim,Mary L. Carlson,David K. Crockett,G. Chris Fillmore,David R. Abbott,Olaotan F. Elenitoba-Johnson,Sheryl R. Tripp,George Z. Rassidakis,L. Jeffrey Medeiros,Philippe Szankasi,Kojo S. J. Elenitoba-Johnson
View Articletitled, The proteomic signature of NPM/ALK reveals deregulation of multiple cellular pathways
Supplemental data

MYELOID NEOPLASIA

Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation
Ayten Kandilci,Gerard C. Grosveld
View Articletitled, Reintroduction of CEBPA in <em>MN1</em>-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation
KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation
Yukimasa Shiotsu,Hitoshi Kiyoi,Yuichi Ishikawa,Ryohei Tanizaki,Makiko Shimizu,Hiroshi Umehara,Kenichi Ishii,Yumiko Mori,Kazutaka Ozeki,Yosuke Minami,Akihiro Abe,Hiroshi Maeda,Tadakazu Akiyama,Yutaka Kanda,Yuko Sato,Shiro Akinaga,Tomoki Naoe
View Articletitled, KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated <em>BCR/ABL</em> translocation
Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia
Jerome Tamburini,Alexa S. Green,Valerie Bardet,Nicolas Chapuis,Sophie Park,Lise Willems,Madalina Uzunov,Norbert Ifrah,François Dreyfus,Catherine Lacombe,Patrick Mayeux,Didier Bouscary
View Articletitled, Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia
Supplemental data
Analysis of the Ten-Eleven Translocation 2 (TET2) gene in familial myeloproliferative neoplasms
Brief Report
Cécile Saint-Martin,Gwendoline Leroy,François Delhommeau,Gérard Panelatti,Sabrina Dupont,Chloé James,Isabelle Plo,Dominique Bordessoule,Christine Chomienne,André Delannoy,Alain Devidas,Martine Gardembas-Pain,Françoise Isnard,Yves Plumelle,Olivier Bernard,William Vainchenker,Albert Najman,Christine Bellanné-Chantelot,the French Group of Familial Myeloproliferative Disorders
View Articletitled, Analysis of the Ten-Eleven Translocation 2 (<em>TET2</em>) gene in familial myeloproliferative neoplasms
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Surface RANKL of Toll-like receptor 4–stimulated human neutrophils activates osteoclastic bone resorption
Arpita Chakravarti,Marie-Astrid Raquil,Philippe Tessier,Patrice E. Poubelle
View Articletitled, Surface RANKL of Toll-like receptor 4–stimulated human neutrophils activates osteoclastic bone resorption

PLATELETS AND THROMBOPOIESIS

Role of sialic acid for platelet life span: exposure of β-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor–expressing liver macrophages and hepatocytes
Anne Louise Sørensen,Viktoria Rumjantseva,Sara Nayeb-Hashemi,Henrik Clausen,John H. Hartwig,Hans H. Wandall,Karin M. Hoffmeister
View Articletitled, Role of sialic acid for platelet life span: exposure of β-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor–expressing liver macrophages and hepatocytes
Association of hereditary thrombocythemia and distal limb defects with a thrombopoietin gene mutation
Brief Report
Claudio Graziano,Simona Carone,Emanuele Panza,Flora Marino,Pamela Magini,Giovanni Romeo,Andrea Pession,Marco Seri
View Articletitled, Association of hereditary thrombocythemia and distal limb defects with a thrombopoietin gene mutation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation
Fionnuala Ni Ainle,Roger J. S. Preston,P. Vincent Jenkins,Hendrik J. Nel,Jennifer A. Johnson,Owen P. Smith,Barry White,Padraic G. Fallon,James S. O'Donnell
View Articletitled, Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
Thomas J. Raife,Wenjing Cao,Bonnie S. Atkinson,Bruce Bedell,Robert R. Montgomery,Steven R. Lentz,George F. Johnson,X. Long Zheng
View Articletitled, Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies
Surya V. Seshan,Claus-Werner Franzke,Patricia Redecha,Marc Monestier,Nigel Mackman,Guillermina Girardi
View Articletitled, Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies

TRANSFUSION MEDICINE

Mislabeled units of umbilical cord blood detected by a quality assurance program at the transplantation center
Jeffrey McCullough,David McKenna,Diane Kadidlo,David Maurer,Harriett J. Noreen,Kathy French,Claudio Brunstein,John E. Wagner
View Articletitled, Mislabeled units of umbilical cord blood detected by a quality assurance program at the transplantation center

TRANSPLANTATION

Impact of HLA disparity in the graft-versus-host direction on engraftment in adult patients receiving reduced-intensity cord blood transplantation
Naofumi Matsuno,Atsushi Wake,Naoyuki Uchida,Kazuya Ishiwata,Hideki Araoka,Shinsuke Takagi,Masanori Tsuji,Hisashi Yamamoto,Daisuke Kato,Yoshiko Matsuhashi,Sachiko Seo,Kazuhiro Masuoka,Shigesaburo Miyakoshi,Shigeyoshi Makino,Akiko Yoneyama,Yoshinobu Kanda,Shuichi Taniguchi
View Articletitled, Impact of HLA disparity in the graft-versus-host direction on engraftment in adult patients receiving reduced-intensity cord blood transplantation

VASCULAR BIOLOGY

Direct crosstalk between mast cell–TNF and TNFR1-expressing endothelia mediates local tissue inflammation
Manfred Kneilling,Reinhard Mailhammer,Lothar Hültner,Tanja Schönberger,Kerstin Fuchs,Martin Schaller,Daniel Bukala,Steffen Massberg,Christian A. Sander,Heidi Braumüller,Martin Eichner,Konrad L. Maier,Rupert Hallmann,Bernd J. Pichler,Roland Haubner,Meinrad Gawaz,Klaus Pfeffer,Tilo Biedermann,Martin Röcken
View Articletitled, Direct crosstalk between mast cell–TNF and TNFR1-expressing endothelia mediates local tissue inflammation
Supplemental data
EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures
Ombretta Salvucci,Dragan Maric,Matina Economopoulou,Shuhei Sakakibara,Simone Merlin,Antonia Follenzi,Giovanna Tosato
View Articletitled, EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures
Supplemental data

CORRESPONDENCE

Sensitivity of serum free light chain measurement of residual disease in multiple myeloma patients
Graham Peter Mead,Mark Trehane Drayson
View Articletitled, Sensitivity of serum free light chain measurement of residual disease in multiple myeloma patients
A novel G6PC3 homozygous 1-bp deletion as a cause of severe congenital neutropenia
Juan I. Aróstegui,José Sánchez de Toledo,Mariona Pascal,Carlos García,Jordi Yagüe,Cristina Díaz de Heredia
View Articletitled, A novel <em>G6PC3</em> homozygous 1-bp deletion as a cause of severe congenital neutropenia

ERRATUM

Harir et al. Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade. Blood. 2008;112(6):2463-2473.
View Articletitled, Harir et al. Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade. <em>Blood</em>. 2008;112(6):2463-2473.
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