Skip Nav Destination
Inhibition of von Willebrand factor–platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons
Outcome of hematopoietic stem cell transplantation for adenosine deaminase–deficient severe combined immunodeficiency
Issue Archive
October 25 2012
In this Issue
Table of Contents
Inside Blood
Blood Work
Review Article
How I Treat
Clinical Trials and Observations
Gene Therapy
Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF–induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems
Yosuke Yokota,Hiroyuki Inoue,Yumiko Matsumura,Haruka Nabeta,Megumi Narusawa,Ayumi Watanabe,Chika Sakamoto,Yasuki Hijikata,Mutsunori Iga-Murahashi,Koichi Takayama,Fumiyuki Sasaki,Yoichi Nakanishi,Takehiko Yokomizo,Kenzaburo Tani
Hematopoiesis and Stem Cells
Immunobiology
Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection
Lydie Trautmann,Florentin-Martial Mbitikon-Kobo,Jean-Philippe Goulet,Yoav Peretz,Yu Shi,Julien Van Grevenynghe,Francesco Andrea Procopio,Mohamad Rachid Boulassel,Jean-Pierre Routy,Nicolas Chomont,Elias K. Haddad,Rafick-Pierre Sekaly
IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells
Solenne Vigne,Gaby Palmer,Praxedis Martin,Céline Lamacchia,Deborah Strebel,Emiliana Rodriguez,Maria L. Olleros,Dominique Vesin,Irene Garcia,Francesca Ronchi,Federica Sallusto,John E. Sims,Cem Gabay
Lymphoid Neoplasia
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
Shannon L. Maude,Sarah K. Tasian,Tiffaney Vincent,Junior W. Hall,Cecilia Sheen,Kathryn G. Roberts,Alix E. Seif,David M. Barrett,I-Ming Chen,J. Racquel Collins,Charles G. Mullighan,Stephen P. Hunger,Richard C. Harvey,Cheryl L. Willman,Jordan S. Fridman,Mignon L. Loh,Stephan A. Grupp,David T. Teachey
Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition
Michele Cea,Antonia Cagnetta,Mariateresa Fulciniti,Yu-Tzu Tai,Teru Hideshima,Dharminder Chauhan,Aldo Roccaro,Antonio Sacco,Teresa Calimeri,Francesca Cottini,Jana Jakubikova,Sun-Young Kong,Franco Patrone,Alessio Nencioni,Marco Gobbi,Paul Richardson,Nikhil Munshi,Kenneth C. Anderson
Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma
Christian Steidl,Arjan Diepstra,Tang Lee,Fong Chun Chan,Pedro Farinha,King Tan,Adele Telenius,Lorena Barclay,Sohrab P. Shah,Joseph M. Connors,Anke van den Berg,Randy D. Gascoyne
Myeloid Neoplasia
Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion
Claudio Tripodo,Sabina Sangaletti,Carla Guarnotta,Pier P. Piccaluga,Matilde Cacciatore,Michela Giuliano,Giovanni Franco,Claudia Chiodoni,Marika Sciandra,Silvia Miotti,Giuseppe Calvaruso,Alessandra Carè,Ada M. Florena,Katia Scotlandi,Attilio Orazi,Stefano A. Pileri,Mario P. Colombo
Phagocytes, Granulocytes, and Myelopoiesis
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Thrombosis and Hemostasis
Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura
Filip Callewaert,Jan Roodt,Hans Ulrichts,Thomas Stohr,Walter Janse van Rensburg,Seb Lamprecht,Stefaan Rossenu,Sofie Priem,Wouter Willems,Josefin-Beate Holz
Inhibition of von Willebrand factor–platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons
Brief Report
Hendrik B. Feys,Jan Roodt,Nele Vandeputte,Inge Pareyn,Harald Mottl,Sam Hou,Seb Lamprecht,Walter J. Van Rensburg,Hans Deckmyn,Karen Vanhoorelbeke
Transplantation
Outcome of hematopoietic stem cell transplantation for adenosine deaminase–deficient severe combined immunodeficiency
CME
Clinical Trials & Observations
Amel Hassan,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Claire Booth,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Alex Brightwell,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Zoe Allwood,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Paul Veys,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Kanchan Rao,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Manfred Hönig,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Wilhelm Friedrich,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Andrew Gennery,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Mary Slatter,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Robbert Bredius,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Andrea Finocchi,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Caterina Cancrini,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Alessandro Aiuti,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Fulvio Porta,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Arnalda Lanfranchi,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Michela Ridella,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Colin Steward,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Alexandra Filipovich,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Rebecca Marsh,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Victoria Bordon,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Saleh Al-Muhsen,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Hamoud Al-Mousa,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Zobaida Alsum,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Hasan Al-Dhekri,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Abdulaziz Al Ghonaium,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Carsten Speckmann,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Alain Fischer,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Nizar Mahlaoui,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Kim E. Nichols,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Eyal Grunebaum,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Daifulah Al Zahrani,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Chaim M. Roifman,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Jaap Boelens,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,E. Graham Davies,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Marina Cavazzana-Calvo,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,Luigi Notarangelo,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency,H. Bobby Gaspar,on behalf of the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation and European Society for Immunodeficiency
Retraction
Other Departments
-
Cover Image
Cover Image
![issue cover]()
Adult hematopoiesis occurs primarily in the bone marrow space where hematopoietic cells interact with stromal niche cells such as osteoblasts. The cover image shows a region of fibrous dysplasia in the bone marrow in the ColI(2.3)+/Rs1+ transgenic mouse model of increased Gs-GPCR signaling in osteoblastic cells. Interspersed between the thin trabeculae of bone are many fibrous stromal cells, including osteoblasts, and small clusters of hematopoietic cells (center). Our findings indicate that long-term activation of Gs signaling in osteoblastic cells leads to contextual changes in the bone marrow niche that adversely affect HSC maintenance and blood homeostasis. The image is a tiled compilation of photos acquired on a Leica DMI4000B microscope (40× objective, with DMC400 camera) of an H&E section from a femur of a 12-week-old ColI(2.3)+/Rs1+ mouse. Image by Dr Edward Hsiao. See the article by Schepers et al on page 3425.
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkBack Matter
- PDF Icon PDF LinkAdvertising
- PDF Icon PDF LinkEditorial Board
Advertisement intended for health care professionals
Email alerts
Advertisement intended for health care professionals
