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Volume 106, Issue 5

September 1 2005

In this Issue

INSIDE BLOOD
BLOOD WORK
REVIEW ARTICLES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

HEMATOPOIESIS

A new spin on hESC differentiation

Manfred Baetscher

View Articletitled, A new spin on hESC differentiation

CLINICAL OBSERVATIONS

Anti-D immune globulin: protecting platelets at a cost

Alan R. Cohen

View Articletitled, Anti-D immune globulin: protecting platelets at a cost

HEMOSTASIS

ICAM-2: regulator of leukocyte migration and angiogenesis

Dietmar Vestweber

View Articletitled, ICAM-2: regulator of leukocyte migration and angiogenesis

HEMATOPOIESIS

Controlled megakaryocytic gene expression

Jerry Ware

View Articletitled, Controlled megakaryocytic gene expression

NEOPLASIA

More and more about less and less

Bruce Matthew Camitta

View Articletitled, More and more about less and less

IMMUNOBIOLOGY

Old and new drugs join forces against hematologic malignancies

Fabio Malavasi

View Articletitled, Old and new drugs join forces against hematologic malignancies

IMMUNOBIOLOGY

Finding a less toxic stem cell therapy for multiple sclerosis

Richard K. Burt

View Articletitled, Finding a less toxic stem cell therapy for multiple sclerosis

RED CELLS

Erythroid Bcl-xL: better late than never

Jeffery L. Miller

View Articletitled, Erythroid Bcl-xL: better late than never

TRANSPLANTATION

Progenitor cell mobilization gets a boost from CXCR4 inhibition

Susan F. Leitman

View Articletitled, Progenitor cell mobilization gets a boost from CXCR4 inhibition

BLOOD WORK

Auer rod

View Articletitled, Auer rod

REVIEW ARTICLES

Effect of transcription-factor concentrations on leukemic stem cells

Frank Rosenbauer,Steffen Koschmieder,Ulrich Steidl,Daniel G. Tenen

View Articletitled, Effect of transcription-factor concentrations on leukemic stem cells

Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells

David A. Ingram,Noel M. Caplice,Mervin C. Yoder

View Articletitled, Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh_o(D) immune globulin intravenous administration for immune thrombocytopenic purpura
Clinical Trials & Observations

Ann Reed Gaines

View Articletitled, Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rho(D) immune globulin intravenous administration for immune thrombocytopenic purpura

Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010
Clinical Trials & Observations

Lawrence D. Kaplan,Jeannette Y. Lee,Richard F. Ambinder,Joseph A. Sparano,Ethel Cesarman,Amy Chadburn,Alexandra M. Levine,David T. Scadden

View Articletitled, Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010

GENE THERAPY

Chimeric NK-receptor–bearing T cells mediate antitumor immunotherapy

Tong Zhang,Bethany A. Lemoi,Charles L. Sentman

View Articletitled, Chimeric NK-receptor–bearing T cells mediate antitumor immunotherapy

Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer

Yubin Kang,Litao Xie,Diane Thi Tran,Colleen S. Stein,Melissa Hickey,Beverly L. Davidson,Paul B. McCray, Jr

View Articletitled, Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer

HEMATOPOIESIS

Conditional overexpression of transgenes in megakaryocytes and platelets in vivo

Hao G. Nguyen,Guangyao Yu,Maria Makitalo,Dan Yang,Hou-Xiang Xie,Matthew R. Jones,Katya Ravid

View Articletitled, Conditional overexpression of transgenes in megakaryocytes and platelets in vivo

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chain^null mice

Fumihiko Ishikawa,Masaki Yasukawa,Bonnie Lyons,Shuro Yoshida,Toshihiro Miyamoto,Goichi Yoshimoto,Takeshi Watanabe,Koichi Akashi,Leonard D. Shultz,Mine Harada

View Articletitled, Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice

Supplemental data

A novel stem-cell population in adult liver with potent hematopoietic-reconstitution activity

Darrell N. Kotton,Attila J. Fabian,Richard C. Mulligan

View Articletitled, A novel stem-cell population in adult liver with potent hematopoietic-reconstitution activity

Supplemental data

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells

Marc Pellegrini,Sue Bath,Vanessa S. Marsden,David C. S. Huang,Donald Metcalf,Alan W. Harris,Andreas Strasser

View Articletitled, FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells

Supplemental data

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Hiromi Iwasaki,Chamorro Somoza,Hirokazu Shigematsu,Estelle A. Duprez,Junko Iwasaki-Arai,Shin-ichi Mizuno,Yojiro Arinobu,Kristin Geary,Pu Zhang,Tajhal Dayaram,Maris L. Fenyus,Shannon Elf,Susan Chan,Philippe Kastner,Claudia S. Huettner,Richard Murray,Daniel G. Tenen,Koichi Akashi

View Articletitled, Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Supplemental data

Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation
Brief Report

Elizabeth S. Ng,Richard P. Davis,Lisa Azzola,Edouard G. Stanley,Andrew G. Elefanty

View Articletitled, Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Tissue-factor–bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation

Ian del Conde,Corie N. Shrimpton,Perumal Thiagarajan,José A. López

View Articletitled, Tissue-factor–bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation

Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression

Yuko Katoh-Fukui,Akiko Owaki,Yoshiro Toyama,Masatomo Kusaka,Yuko Shinohara,Mamiko Maekawa,Kiyotaka Toshimori,Ken-ichirou Morohashi

View Articletitled, Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression

The heparin-binding site of antithrombin is crucial for antiangiogenic activity

Weiqing Zhang,Richard Swanson,Gonzalo Izaguirre,Yan Xiong,Lester F. Lau,Steven T. Olson

View Articletitled, The heparin-binding site of antithrombin is crucial for antiangiogenic activity

Inhibition of APC anticoagulant activity on oxidized phospholipid by anti–β₂-glycoprotein I monoclonal antibodies

Omid Safa,Charles T. Esmon,Naomi L. Esmon

View Articletitled, Inhibition of APC anticoagulant activity on oxidized phospholipid by anti–β2-glycoprotein I monoclonal antibodies

Endothelial intercellular adhesion molecule (ICAM)–2 regulates angiogenesis

Miao-Tzu Huang,Justin C. Mason,Graeme M. Birdsey,Valerie Amsellem,Nicole Gerwin,Dorian O. Haskard,Anne J. Ridley,Anna M. Randi

View Articletitled, Endothelial intercellular adhesion molecule (ICAM)–2 regulates angiogenesis

Interplay between P2Y₁, P2Y₁₂, and P2X₁ receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling

Gwen Tolhurst,Catherine Vial,Catherine Léon,Christian Gachet,Richard J. Evans,Martyn P. Mahaut-Smith

View Articletitled, Interplay between P2Y1, P2Y12, and P2X1 receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling

Supplemental data

IMMUNOBIOLOGY

Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95ΔTM), is the basis for ALPS Ia in a family with duplicated 3′ splice site AG in CD95 intron 5 on one allele
Clinical Trials & Observations

Joachim Roesler,Jose-Maria Izquierdo,Martin Ryser,Angela Rösen-Wolff,Manfred Gahr,Juan Valcarcel,Michael J. Lenardo,Lixin Zheng

View Articletitled, Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95ΔTM), is the basis for ALPS Ia in a family with duplicated 3′ splice site AG in CD95 intron 5 on one allele

Supplemental data

Early proliferation of CCR5⁺ CD38⁺⁺⁺ antigen-specific CD4⁺ Th1 effector cells during primary HIV-1 infection

John J. Zaunders,Mee Ling Munier,Daniel E. Kaufmann,Susanna Ip,Pat Grey,Don Smith,Tim Ramacciotti,Dick Quan,Robert Finlayson,John Kaldor,Eric S. Rosenberg,Bruce D. Walker,David A. Cooper,Anthony D. Kelleher,on behalf of the PHAEDRA Study Team

View Articletitled, Early proliferation of CCR5+ CD38+++ antigen-specific CD4+ Th1 effector cells during primary HIV-1 infection

Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation

Mark M. W. Chong,Donald Metcalf,Emma Jamieson,Warren S. Alexander,Thomas W. H. Kay

View Articletitled, Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation

Supplemental data

Malaria-specific transgenic CD4⁺ T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance

Robin Stephens,Frank R. Albano,Stuart Quin,Benjamin J. Pascal,Vicky Harrison,Brigitta Stockinger,Dimitris Kioussis,Hans-Ulrich Weltzien,Jean Langhorne

View Articletitled, Malaria-specific transgenic CD4+ T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance

Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions

Keita Minami,Yoshiki Yanagawa,Kazuya Iwabuchi,Nobuo Shinohara,Toru Harabayashi,Katsuya Nonomura,Kazunori Onoé

View Articletitled, Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions

Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression

Christine Chauveau,Séverine Rémy,Pierre Joseph Royer,Marcelo Hill,Séverine Tanguy-Royer,François-Xavier Hubert,Laurent Tesson,Régis Brion,Gaëlle Beriou,Marc Gregoire,Régis Josien,Maria Cristina Cuturi,Ignacio Anegon

View Articletitled, Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression

Supplemental data

Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn

Mark Löwenberg,Jurriaan Tuynman,Joyce Bilderbeek,Timo Gaber,Frank Buttgereit,Sander van Deventer,Maikel Peppelenbosch,Daniel Hommes

View Articletitled, Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn

Supplemental data

Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand–expressing tumor cells

Jérôme D. Coudert,Jacques Zimmer,Elena Tomasello,Marek Cebecauer,Marco Colonna,Eric Vivier,Werner Held

View Articletitled, Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand–expressing tumor cells

Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys

Domenico Mavilio,Janet Benjamin,Diana Kim,Gabriella Lombardo,Marybeth Daucher,Audrey Kinter,Elizabeth Nies-Kraske,Emanuela Marcenaro,Alessandro Moretta,Anthony S. Fauci

View Articletitled, Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys

Cooperating pre–T-cell receptor and TCF-1–dependent signals ensure thymocyte survival

Delphine Goux,Jérôme D. Coudert,Diane Maurice,Leonardo Scarpellino,Grégoire Jeannet,Stefano Piccolo,Kathleen Weston,Joerg Huelsken,Werner Held

View Articletitled, Cooperating pre–T-cell receptor and TCF-1–dependent signals ensure thymocyte survival

Efficient migration of dendritic cells toward lymph node chemokines and induction of T_H1 responses require maturation stimulus and apoptotic cell interaction

Nicolas Bertho,Henri Adamski,Louis Toujas,Martine Debove,Jean Davoust,Veronique Quillien

View Articletitled, Efficient migration of dendritic cells toward lymph node chemokines and induction of TH1 responses require maturation stimulus and apoptotic cell interaction

Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis

Arnon P. Kater,Frank Dicker,Massimo Mangiola,Kate Welsh,Richard Houghten,John Ostresh,Adel Nefzi,John C. Reed,Clemencia Pinilla,Thomas J. Kipps

View Articletitled, Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis

Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia

W. Nicholas Haining,Donna S. Neuberg,Heather L. Keczkemethy,John W. Evans,Stephen Rivoli,Rebecca Gelman,Howard M. Rosenblatt,William T. Shearer,Javier Guenaga,Daniel C. Douek,Lewis B. Silverman,Stephen E. Sallan,Eva C. Guinan,Lee M. Nadler

View Articletitled, Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia

Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy

Emanuela Zappia,Simona Casazza,Enrico Pedemonte,Federica Benvenuto,Ivan Bonanni,Ezio Gerdoni,Debora Giunti,Antonella Ceravolo,Francesco Cazzanti,Francesco Frassoni,Gianluigi Mancardi,Antonio Uccelli

View Articletitled, Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy

NEOPLASIA

AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping
Clinical Trials & Observations

Christian Hoffmann,Markus Tiemann,Carsten Schrader,Dirk Janssen,Eva Wolf,Mathias Vierbuchen,Reza Parwaresch,Karen Ernestus,Andreas Plettenberg,Albrecht Stoehr,Gerd Fatkenheuer,Christoph Wyen,Mark Oette,Heinz-August Horst

View Articletitled, AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping

Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma
Clinical Trials & Observations

Hiroyuki Tagawa,Miyuki Suguro,Shinobu Tsuzuki,Keitaro Matsuo,Sivasundaram Karnan,Koichi Ohshima,Masataka Okamoto,Yasuo Morishima,Shigeo Nakamura,Masao Seto

View Articletitled, Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma

Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment

Gianluigi Zaza,Meyling Cheok,Wenjian Yang,John C. Panetta,Ching-Hon Pui,Mary V. Relling,William E. Evans

View Articletitled, Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment

Supplemental data

Wnts induce migration and invasion of myeloma plasma cells

Ya-Wei Qiang,Katie Walsh,Lei Yao,Noemi Kedei,Peter M. Blumberg,Jeffrey S. Rubin,John Shaughnessy, Jr,Stuart Rudikoff

View Articletitled, Wnts induce migration and invasion of myeloma plasma cells

Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis

Kenji Ishitsuka,Teru Hideshima,Makoto Hamasaki,Noopur Raje,Shaji Kumar,Hiromasa Hideshima,Norihiko Shiraishi,Hiroshi Yasui,Aldo M. Roccaro,Paul Richardson,Klaus Podar,Steven Le Gouill,Dharminder Chauhan,Kazuo Tamura,Jack Arbiser,Kenneth C. Anderson

View Articletitled, Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis

A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein β and NF-κB activity in Hodgkin and anaplastic large cell lymphomas

Franziska Jundt,Nina Raetzel,Christine Müller,Cornelis F. Calkhoven,Katharina Kley,Stephan Mathas,Andreas Lietz,Achim Leutz,Bernd Dörken

View Articletitled, A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein β and NF-κB activity in Hodgkin and anaplastic large cell lymphomas

Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression

Erwan Le Scolan,Dimitri Pchejetski,Yoshiko Banno,Nicole Denis,Patrick Mayeux,William Vainchenker,Thierry Levade,Françoise Moreau-Gachelin

View Articletitled, Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression

Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia

Amy Holleman,Monique L. den Boer,Karin M. Kazemier,H. Berna Beverloo,Anne R. M. von Bergh,Gritta E. Janka-Schaub,Rob Pieters

View Articletitled, Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia

Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells

Meike Burger,Tanja Hartmann,Myriam Krome,Justyna Rawluk,Hirokazu Tamamura,Nobutaka Fujii,Thomas J. Kipps,Jan A. Burger

View Articletitled, Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells

Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis
Clinical Trials & Observations

Elena Ruiz-Ballesteros,Manuela Mollejo,Antonia Rodriguez,Francisca I. Camacho,Patrocinio Algara,Nerea Martinez,Marina Pollán,Abel Sanchez-Aguilera,Javier Menarguez,Elias Campo,Pedro Martinez,Marisol Mateo,Miguel A. Piris

View Articletitled, Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis

The fully human anti-CD30 antibody 5F11 activates NF-κB and sensitizes lymphoma cells to bortezomib-induced apoptosis
Brief Report

Boris Böll,Hinrich Hansen,Friederike Heuck,Katrin Reiners,Peter Borchmann,Achim Rothe,Andreas Engert,Elke Pogge von Strandmann

View Articletitled, The fully human anti-CD30 antibody 5F11 activates NF-κB and sensitizes lymphoma cells to bortezomib-induced apoptosis

PHAGOCYTES

Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes

Valérie Abadie,Edgar Badell,Patrice Douillard,Danielle Ensergueix,Pieter J. M. Leenen,Myriam Tanguy,Laurence Fiette,Sem Saeland,Brigitte Gicquel,Nathalie Winter

View Articletitled, Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes

Supplemental data

RED CELLS

Life-threatening nonspherocytic hemolytic anemia in a patient with a null mutation in the PKLR gene and no compensatory PKM gene expression
Clinical Trials & Observations

Amalia Diez,Florinda Gilsanz,Joaquin Martinez,Susana Pérez-Benavente,Néstor W. Meza,José M. Bautista

View Articletitled, Life-threatening nonspherocytic hemolytic anemia in a patient with a null mutation in the PKLR gene and no compensatory PKM gene expression

Bcl-x_L prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin

Melissa M. Rhodes,Prapaporn Kopsombut,Maurice C. Bondurant,James O. Price,Mark J. Koury

View Articletitled, Bcl-xL prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin

Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
Clinical Trials & Observations Brief Report

Erwin Kemna,Peter Pickkers,Elizabeta Nemeth,Hans van der Hoeven,Dorine Swinkels

View Articletitled, Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS

TRANSPLANTATION

The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone

Neal Flomenberg,Steven M. Devine,John F. DiPersio,Jane L. Liesveld,John M. McCarty,Scott D. Rowley,David H. Vesole,Karin Badel,Gary Calandra

View Articletitled, The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone

Tolerance induction by bone marrow transplantation in a multiple sclerosis model

Martin M. Herrmann,Susanne Gaertner,Christine Stadelmann,Jens van den Brandt,Robert Böscke,Wilfried Budach,Holger M. Reichardt,Robert Weissert

View Articletitled, Tolerance induction by bone marrow transplantation in a multiple sclerosis model

CORRESPONDENCE

Analyses of protein S function

Kenneth G. Mann

View Articletitled, Analyses of protein S function

CD34 expression by mast cells: of mice and men

Erin Drew,Claudia S. Huettner,Daniel G. Tenen,Kelly M. McNagny

View Articletitled, CD34 expression by mast cells: of mice and men

Independent clones at separable stages of differentiation, bearing different GATA1 mutations, in the same TMD patient with Down syndrome

Jürgen Groet,Claire Mulligan,Monica Spinelli,Anna Serra,Suzanne McElwaine,Finbarr E. Cotter,Franca Dagna-Bricarelli,Giuseppe Saglio,Giuseppe Basso,Dean Nizetic

View Articletitled, Independent clones at separable stages of differentiation, bearing different GATA1 mutations, in the same TMD patient with Down syndrome

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Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

REVIEW ARTICLES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rho(D) immune globulin intravenous administration for immune thrombocytopenic purpura Clinical Trials & Observations

Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010 Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95ΔTM), is the basis for ALPS Ia in a family with duplicated 3′ splice site AG in CD95 intron 5 on one allele Clinical Trials & Observations

NEOPLASIA

AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping Clinical Trials & Observations

Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma Clinical Trials & Observations

Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis Clinical Trials & Observations

The fully human anti-CD30 antibody 5F11 activates NF-κB and sensitizes lymphoma cells to bortezomib-induced apoptosis Brief Report

PHAGOCYTES

RED CELLS

Life-threatening nonspherocytic hemolytic anemia in a patient with a null mutation in the PKLR gene and no compensatory PKM gene expression Clinical Trials & Observations

Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS Clinical Trials & Observations Brief Report

TRANSPLANTATION

CORRESPONDENCE

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh_o(D) immune globulin intravenous administration for immune thrombocytopenic purpura
Clinical Trials & Observations

Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010
Clinical Trials & Observations

Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation
Brief Report

Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95ΔTM), is the basis for ALPS Ia in a family with duplicated 3′ splice site AG in CD95 intron 5 on one allele
Clinical Trials & Observations

AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping
Clinical Trials & Observations

Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma
Clinical Trials & Observations

Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis
Clinical Trials & Observations

The fully human anti-CD30 antibody 5F11 activates NF-κB and sensitizes lymphoma cells to bortezomib-induced apoptosis
Brief Report

Life-threatening nonspherocytic hemolytic anemia in a patient with a null mutation in the PKLR gene and no compensatory PKM gene expression
Clinical Trials & Observations

Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
Clinical Trials & Observations Brief Report