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Volume 108, Issue 8

October 15 2006

In this Issue

INSIDE BLOOD
REVIEW IN TRANSLATIONAL HEMATOLOGY
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
STEM CELLS IN HEMATOLOGY
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

GENE THERAPY

The SINister side of retrovirus vectors

David W. Emery

View Articletitled, The SINister side of retrovirus vectors

CLINICAL TRIALS AND OBSERVATIONS

Autologous transplantation for follicular lymphoma? Not too soon!
Clinical Trials & Observations

Koen van Besien

View Articletitled, Autologous transplantation for follicular lymphoma? Not too soon!

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Thymus colonization: a shared responsibility

Graham Anderson

View Articletitled, Thymus colonization: a shared responsibility

HEMOSTASIS

Impaired megakaryocytopoiesis in type 2B von Willebrand disease

Augusto B. Federici

View Articletitled, Impaired megakaryocytopoiesis in type 2B von Willebrand disease

NEOPLASIA

Gene expression relates WM to CLL

Adrian Wiestner

View Articletitled, Gene expression relates WM to CLL

NEOPLASIA

ALK-mediated oncogenesis: mechanisms that matter

Stephan W. Morris

View Articletitled, ALK-mediated oncogenesis: mechanisms that matter

NEOPLASIA

FLT3: the root of the problem

Mark Levis

View Articletitled, FLT3: the root of the problem

PHAGOCYTES

Neutrophil chemotaxis: a tail of 2 GTPases

Mary C. Dinauer

View Articletitled, Neutrophil chemotaxis: a tail of 2 GTPases

PHAGOCYTES

Supplying neutrophils from the bone marrow to the tissues

David C. Dale

View Articletitled, Supplying neutrophils from the bone marrow to the tissues

TRANSPLANTATION

Chronic GVHD and health status in long-term survivors

Gérard Socie

View Articletitled, Chronic GVHD and health status in long-term survivors

RED CELLS

A novel defense against hemolytic-oxidative stress

Gregory J. Kato,Mark T. Gladwin

View Articletitled, A novel defense against hemolytic-oxidative stress

PHAGOCYTES

Nanotechnology and antiretroviral therapy

Masanori Baba

View Articletitled, Nanotechnology and antiretroviral therapy

HEMOSTASIS

VEGF calls its receptors from the recycling compartment

Yihai Cao

View Articletitled, VEGF calls its receptors from the recycling compartment

REVIEW IN TRANSLATIONAL HEMATOLOGY

Current concepts in the pathophysiology and treatment of aplastic anemia
Clinical Trials & Observations

Neal S. Young,Rodrigo T. Calado,Phillip Scheinberg

View Articletitled, Current concepts in the pathophysiology and treatment of aplastic anemia

Dangerous small B-cell clones

Giampaolo Merlini,Marvin J. Stone

View Articletitled, Dangerous small B-cell clones

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization

Cunlan Liu,Fumi Saito,Zhijie Liu,Yu Lei,Shoji Uehara,Paul Love,Martin Lipp,Shunzo Kondo,Nancy Manley,Yousuke Takahama

View Articletitled, Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization

Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Standard chemotherapy with interferon compared with CHOP followed by high-dose therapy with autologous stem cell transplantation in untreated patients with advanced follicular lymphoma: the GELF-94 randomized study from the Groupe d'Etude des Lymphomes de l'Adulte (GELA)
Clinical Trials & Observations

Catherine Sebban,Nicolas Mounier,Nicole Brousse,Coralie Belanger,Pauline Brice,Corinne Haioun,Herve Tilly,Pierre Feugier,Redah Bouabdallah,Chantal Doyen,Gilles Salles,Bertrand Coiffier

View Articletitled, Standard chemotherapy with interferon compared with CHOP followed by high-dose therapy with autologous stem cell transplantation in untreated patients with advanced follicular lymphoma: the GELF-94 randomized study from the Groupe d'Etude des Lymphomes de l'Adulte (GELA)

GENE THERAPY

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

Ute Modlich,Jens Bohne,Manfred Schmidt,Christof von Kalle,Sabine Knöss,Axel Schambach,Christopher Baum

View Articletitled, Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

Supplemental data

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

Alan L. Parker,Simon N. Waddington,Campbell G. Nicol,Dmitry M. Shayakhmetov,Suzanne M. Buckley,Laura Denby,Geoffrey Kemball-Cook,Shaoheng Ni,Andre Lieber,John H. McVey,Stuart A. Nicklin,Andrew H. Baker

View Articletitled, Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

HEMATOPOIESIS

Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis

Craig H. Mermel,Morgan L. McLemore,Fulu Liu,Shalini Pereira,Jill Woloszynek,Clifford A. Lowell,Daniel C. Link

View Articletitled, Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis

Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo

Climent Casals-Pascual,Oscar Kai,Joyce O. P. Cheung,Senani Williams,Brett Lowe,Mike Nyanoti,Thomas N. Williams,Kathryn Maitland,Malcolm Molyneux,Charles R. J. C. Newton,Norbert Peshu,Suzanne M. Watt,David J. Roberts

View Articletitled, Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo

Supplemental data

CD99 expressed on human mobilized peripheral blood CD34⁺ cells is involved in transendothelial migration

Anne-Marie Imbert,Ghania Belaaloui,Florence Bardin,Cecile Tonnelle,Marc Lopez,Christian Chabannon

View Articletitled, CD99 expressed on human mobilized peripheral blood CD34+ cells is involved in transendothelial migration

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia
Clinical Trials & Observations

Paquita Nurden,Najet Debili,William Vainchenker,Regis Bobe,Raymonde Bredoux,Elisabeth Corvazier,Robert Combrie,Edith Fressinaud,Dominique Meyer,Alan T. Nurden,Jocelyne Enouf

View Articletitled, Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia

Supplemental data

Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo

Junling Liu,Malinda E. Fitzgerald,Michael C. Berndt,Carl W. Jackson,T. Kent Gartner

View Articletitled, Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo

A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation
Clinical Trials & Observations

Michiel Coppens,Marlene H. van de Poel,Ivan Bank,Karly Hamulyak,Jan van der Meer,Nic J. Veeger,Martin H. Prins,Harry R. Buller,Saskia Middeldorp

View Articletitled, A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation

Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells

Pierre Fons,Sophie Chabot,Judith E. Cartwright,Francoise Lenfant,Fatima L'Faqihi,Jerome Giustiniani,Jean-Pascal Herault,Genevieve Gueguen,Françoise Bono,Pierre Savi,Maryse Aguerre-Girr,Sylvie Fournel,François Malecaze,Armand Bensussan,Jean Plouët,Philippe Le Bouteiller

View Articletitled, Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells

Supplemental data

Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase

Lynette M. Kilpatrick,Roger L. Harris,Kate A. Owen,Rosemary Bass,Christine Ghorayeb,Amit Bar-Or,Vincent Ellis

View Articletitled, Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase

VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment

Alexandra Gampel,Lara Moss,Matt C. Jones,Val Brunton,Jim C. Norman,Harry Mellor

View Articletitled, VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment

IMMUNOBIOLOGY

Molecular strategies for detection and quantitation of clonal cytotoxic T-cell responses in aplastic anemia and myelodysplastic syndrome

Marcin W. Wlodarski,Lukasz P. Gondek,Zachary P. Nearman,Magdalena Plasilova,Matt Kalaycio,Eric D. Hsi,Jaroslaw P. Maciejewski

View Articletitled, Molecular strategies for detection and quantitation of clonal cytotoxic T-cell responses in aplastic anemia and myelodysplastic syndrome

CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells

Dominic F. Kelly,Mathew D. Snape,Elizabeth A. Clutterbuck,Sarah Green,Claire Snowden,Linda Diggle,Ly-mee Yu,Astrid Borkowski,E. Richard Moxon,Andrew J. Pollard

View Articletitled, CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells

Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab

Julie A. Bowles,Siao-Yi Wang,Brian K. Link,Barrett Allan,Gregory Beuerlein,Mary-Ann Campbell,David Marquis,Brian Ondek,James E. Wooldridge,Brian J. Smith,James B. Breitmeyer,George J. Weiner

View Articletitled, Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab

Expansion of FOXP3^high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients

Devi K. Banerjee,Madhav V. Dhodapkar,Elyana Matayeva,Ralph M. Steinman,Kavita M. Dhodapkar

View Articletitled, Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients

Identification of an immunogenic CD8⁺ T-cell epitope derived from γ-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia

Naoto Hirano,Marcus O. Butler,Zhinan Xia,Alla Berezovskaya,Andrew P. Murray,Sascha Ansén,Seiji Kojima,Lee M. Nadler

View Articletitled, Identification of an immunogenic CD8+ T-cell epitope derived from γ-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia

c-Myc mediates pre-TCR-induced proliferation but not developmental progression

Marei Dose,Irum Khan,Zhuyan Guo,Damian Kovalovsky,Andreas Krueger,Harald von Boehmer,Khashayarsha Khazaie,Fotini Gounari

View Articletitled, c-Myc mediates pre-TCR-induced proliferation but not developmental progression

DIgR2, dendritic cell-derived immunoglobulin receptor 2, is one representative of a family of IgSF inhibitory receptors and mediates negative regulation of dendritic cell-initiated antigen-specific T-cell responses

Liyun Shi,Kun Luo,Dajing Xia,Taoyong Chen,Guoyou Chen,Yingming Jiang,Nan Li,Xuetao Cao

View Articletitled, DIgR2, dendritic cell-derived immunoglobulin receptor 2, is one representative of a family of IgSF inhibitory receptors and mediates negative regulation of dendritic cell-initiated antigen-specific T-cell responses

A role for BLyS in the activation of innate immune cells

Sook Kyung Chang,Bonnie K. Arendt,Jaime R. Darce,Xiaosheng Wu,Diane F. Jelinek

View Articletitled, A role for BLyS in the activation of innate immune cells

Supplemental data

BCL11B participates in the activation of IL2 gene expression in CD4⁺ T lymphocytes

Valeriu B. Cismasiu,Sailaja Ghanta,Javier Duque,Diana I. Albu,Hong-Mei Chen,Rohini Kasturi,Dorina Avram

View Articletitled, BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes

Supplemental data

BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces κ gene rearrangement

Mutsumi Yamamoto,Katsuhiko Hayashi,Takuya Nojima,Yumi Matsuzaki,Yohei Kawano,Hajime Karasuyama,Ryo Goitsuka,Daisuke Kitamura

View Articletitled, BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces κ gene rearrangement

B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation

Bernd Jahrsdörfer,Sue E. Blackwell,James E. Wooldridge,Jian Huang,Melinda W. Andreski,Laura S. Jacobus,Christiana M. Taylor,George J. Weiner

View Articletitled, B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation

Supplemental data

NEOPLASIA

FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma
Clinical Trials & Observations

Dong Hwan Kim,Hee Du Jung,Jong Gwang Kim,Je-Jung Lee,Deok-Hwan Yang,Yeon Hee Park,Young Rok Do,Ho Jin Shin,Min Kyoung Kim,Myung Soo Hyun,Sang Kyun Sohn

View Articletitled, FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma

Supplemental data

SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice

Yupo Ma,Wei Cui,Jianchang Yang,Jun Qu,Chunhui Di,Hesham M. Amin,Raymond Lai,Jerome Ritz,Diane S. Krause,Li Chai

View Articletitled, SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice

Characterization of a humanized IgG4 anti-HLA-DR monoclonal antibody that lacks effector cell functions but retains direct antilymphoma activity and increases the potency of rituximab

Rhona Stein,Zhengxing Qu,Susan Chen,David Solis,Hans J. Hansen,David M. Goldenberg

View Articletitled, Characterization of a humanized IgG4 anti-HLA-DR monoclonal antibody that lacks effector cell functions but retains direct antilymphoma activity and increases the potency of rituximab

Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor

Patrick P. Ng,Gustavo Helguera,Tracy R. Daniels,Simon Z. Lomas,Jose A. Rodriguez,Gary Schiller,Benjamin Bonavida,Sherie L. Morrison,Manuel L. Penichet

View Articletitled, Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor

Supplemental data

Gene-expression profiling of Waldenström macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma

Wee J. Chng,Roelandt F. Schop,Tammy Price-Troska,Irene Ghobrial,Neil Kay,Diane F. Jelinek,Morie A. Gertz,Angela Dispenzieri,Martha Lacy,Robert A. Kyle,Philip R. Greipp,Renee C. Tschumper,Rafael Fonseca,Peter Leif Bergsagel

View Articletitled, Gene-expression profiling of Waldenström macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma

Supplemental data

FLT3 internal tandem duplication in CD34⁺/CD33^- precursors predicts poor outcome in acute myeloid leukemia
Clinical Trials & Observations

Jessica A. Pollard,Todd A. Alonzo,Robert B. Gerbing,William G. Woods,Beverly J. Lange,David A. Sweetser,Jerald P. Radich,Irwin D. Bernstein,Soheil Meshinchi

View Articletitled, FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia

JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

Thomas Mercher,Gerlinde Wernig,Sandra A. Moore,Ross L. Levine,Ting-Lei Gu,Stefan Fröhling,Dana Cullen,Roberto D. Polakiewicz,Olivier A. Bernard,Titus J. Boggon,Benjamin H. Lee,D. Gary Gilliland

View Articletitled, JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

Supplemental data

A “liaison dangereuse” between AUF1/hnRNPD and the oncogenic tyrosine kinase NPM-ALK

Mohamad Fawal,Florence Armstrong,Severine Ollier,Henri Dupont,Christian Touriol,Bernard Monsarrat,Georges Delsol,Bernard Payrastre,Dominique Morello

View Articletitled, A “liaison dangereuse” between AUF1/hnRNPD and the oncogenic tyrosine kinase NPM-ALK

Dysregulation of IL-15-mediated T-cell homeostasis in TGF-β dominant-negative receptor transgenic mice

Philip J. Lucas,Seong-Jin Kim,Crystal L. Mackall,William G. Telford,Yu-Waye Chu,Frances T. Hakim,Ronald E. Gress

View Articletitled, Dysregulation of IL-15-mediated T-cell homeostasis in TGF-β dominant-negative receptor transgenic mice

Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK⁺ anaplastic large-cell lymphoma

Yajun Han,Hesham M. Amin,Bevin Franko,Christine Frantz,Xinzhe Shi,Raymond Lai

View Articletitled, Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma

Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications

Masood A. Shammas,Paola Neri,Hemanta Koley,Ramesh B. Batchu,Robert C. Bertheau,Vidit Munshi,Rao Prabhala,Mariateresa Fulciniti,Yu tzu Tai,Steven P. Treon,Raj K. Goyal,Kenneth C. Anderson,Nikhil C. Munshi

View Articletitled, Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications

Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia
Clinical Trials & Observations Brief Report

Craig Kovitz,Hagop Kantarjian,Guillermo Garcia-Manero,Lynne V. Abruzzo,Jorge Cortes

View Articletitled, Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia

PHAGOCYTES

Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis

Kersi N. Pestonjamasp,Carol Forster,Chunxiang Sun,Elisabeth M. Gardiner,Ben Bohl,Orion Weiner,Gary M. Bokoch,Michael Glogauer

View Articletitled, Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis

Supplemental data

Timing of neutrophil tissue repopulation predicts restoration of innate immune protection in a murine bone marrow transplantation model

Chrisovalantou Cheretakis,Roland Leung,Chun Xiang Sun,Yigal Dror,Michael Glogauer

View Articletitled, Timing of neutrophil tissue repopulation predicts restoration of innate immune protection in a murine bone marrow transplantation model

Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery

Huanyu Dou,Christopher J. Destache,Justin R. Morehead,R. Lee Mosley,Michael D. Boska,Jeffrey Kingsley,Santhi Gorantla,Larisa Poluektova,Jay A. Nelson,Mahesh Chaubal,Jane Werling,James Kipp,Barrett E. Rabinow,Howard E. Gendelman

View Articletitled, Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery

Supplemental data

RED CELLS

MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells

Evan P. Kransdorf,Shou Zhen Wang,Sheng Zu Zhu,Timothy B. Langston,Jeremy W. Rupon,Gordon D. Ginder

View Articletitled, MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells

Supplemental data

Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein
Brief Report

Marianne Jensby Nielsen,Steen Vang Petersen,Christian Jacobsen,Claus Oxvig,David Rees,Holger Jon Møller,Søren Kragh Moestrup

View Articletitled, Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein

STEM CELLS IN HEMATOLOGY

Non-side-population hematopoietic stem cells in mouse bone marrow

Yohei Morita,Hideo Ema,Satoshi Yamazaki,Hiromitsu Nakauchi

View Articletitled, Non-side-population hematopoietic stem cells in mouse bone marrow

Supplemental data

VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133⁺ stem cells after intra-arterial transplantation

Manuela Gavina,Marzia Belicchi,Barbara Rossi,Linda Ottoboni,Fabio Colombo,Mirella Meregalli,Maurizio Battistelli,Laura Forzenigo,Piero Biondetti,Federica Pisati,Daniele Parolini,Andrea Farini,Andrew C. Issekutz,Nereo Bresolin,Franco Rustichelli,Gabriela Constantin,Yvan Torrente

View Articletitled, VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation

TRANSPLANTATION

Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor Study

Christopher J. Fraser,Smita Bhatia,Kirsten Ness,Andrea Carter,Liton Francisco,Mukta Arora,Pablo Parker,Stephen Forman,Daniel Weisdorf,James G. Gurney,K. Scott Baker

View Articletitled, Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor Study

Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantation

Claudio G. Brunstein,Daniel J. Weisdorf,Todd DeFor,Juliet N. Barker,Jakub Tolar,Jo-Anne H. van Burik,John E. Wagner

View Articletitled, Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantation

CORRESPONDENCE

Varying response to escalating the dose of imatinib in patients with CML who “acquire” a BCR-ABL^M244V mutant allele

Mona Anand,Jamshid Khorashad,David Marin,Jane F. Apperley,John M. Goldman,Jaspal Singh Kaeda

View Articletitled, Varying response to escalating the dose of imatinib in patients with CML who “acquire” a BCR-ABLM244V mutant allele

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Issue Archive

Table of Contents

INSIDE BLOOD

Autologous transplantation for follicular lymphoma? Not too soon! Clinical Trials & Observations

REVIEW IN TRANSLATIONAL HEMATOLOGY

Current concepts in the pathophysiology and treatment of aplastic anemia Clinical Trials & Observations

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia Clinical Trials & Observations

A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation Clinical Trials & Observations

IMMUNOBIOLOGY

NEOPLASIA

FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma Clinical Trials & Observations

FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia Clinical Trials & Observations

Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia Clinical Trials & Observations Brief Report

PHAGOCYTES

RED CELLS

Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein Brief Report

STEM CELLS IN HEMATOLOGY

TRANSPLANTATION

CORRESPONDENCE

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Autologous transplantation for follicular lymphoma? Not too soon!
Clinical Trials & Observations

Current concepts in the pathophysiology and treatment of aplastic anemia
Clinical Trials & Observations

Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia
Clinical Trials & Observations

A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation
Clinical Trials & Observations

FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma
Clinical Trials & Observations

FLT3 internal tandem duplication in CD34⁺/CD33^- precursors predicts poor outcome in acute myeloid leukemia
Clinical Trials & Observations

Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia
Clinical Trials & Observations Brief Report

Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein
Brief Report