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Volume 121, Issue 23
June 6 2013
Issue Cover

Table of Contents

INSIDE BLOOD

TRANSPLANTATION
MEKing it easier to prevent GVHD
Paul J. Martin
View Articletitled, MEKing it easier to prevent GVHD
IMMUNOBIOLOGY
Extracellular microRNAs turn on NK cells via TLR1
Todd A. Fehniger
View Articletitled, Extracellular microRNAs turn on NK cells via TLR1
RED CELLS, IRON, & ERYTHROPOIESIS
Congenital dyserythropoietic anemias: III's a charm
Elizabeth Traxler,Mitchell J. Weiss
View Articletitled, Congenital dyserythropoietic anemias: III's a charm

BLOOD WORK

Acute promyelocytic leukemia presenting as a mass in the external ear
Matthew Seftel,Anna Serebrin
View Articletitled, Acute promyelocytic leukemia presenting as a mass in the external ear

PLENARY PAPER

MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner
Takero Shindo,Tae Kon Kim,Cara L. Benjamin,Eric D. Wieder,Robert B. Levy,Krishna V. Komanduri
View Articletitled, MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner
Supplemental data

REVIEW ARTICLE

SF3B1 mutations in chronic lymphocytic leukemia
Youzhong Wan,Catherine J. Wu
View Articletitled, <em>SF3B1</em> mutations in chronic lymphocytic leukemia

CLINICAL TRIALS AND OBSERVATIONS

The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial
Clinical Trials & Observations
Peter W. Hunt,Nancy S. Shulman,Timothy L. Hayes,Viktor Dahl,Ma Somsouk,Nicholas T. Funderburg,Bridget McLaughlin,Alan L. Landay,Oluwatoyin Adeyemi,Lee E. Gilman,Brian Clagett,Benigno Rodriguez,Jeffrey N. Martin,Timothy W. Schacker,Barbara L. Shacklett,Sarah Palmer,Michael M. Lederman,Steven G. Deeks
View Articletitled, The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial
Supplemental data
Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase 3 trial
Clinical Trials & Observations
Ulf-Henrik Mellqvist,Peter Gimsing,Oyvind Hjertner,Stig Lenhoff,Edward Laane,Kari Remes,Hlif Steingrimsdottir,Niels Abildgaard,Lucia Ahlberg,Cecilie Blimark,Inger Marie Dahl,Karin Forsberg,Tobias Gedde-Dahl,Henrik Gregersen,Astrid Gruber,Nina Guldbrandsen,Einar Haukås,Kristina Carlson,Ann Kristin Kvam,Hareth Nahi,Roald Lindås,Niels Frost Andersen,Ingemar Turesson,Anders Waage,Jan Westin,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group,for the Nordic Myeloma Study Group
View Articletitled, Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase 3 trial
Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation
Clinical Trials & Observations
Farhad Ravandi,Mona Lisa Alattar,Michael R. Grunwald,Michelle A. Rudek,Trivikram Rajkhowa,Mary Ann Richie,Sherry Pierce,Naval Daver,Guillermo Garcia-Manero,Stefan Faderl,Aziz Nazha,Marina Konopleva,Gautam Borthakur,Jan Burger,Tapan Kadia,Sara Dellasala,Michael Andreeff,Jorge Cortes,Hagop Kantarjian,Mark Levis
View Articletitled, Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and <em>FLT</em>-3 internal tandem duplication mutation
Supplemental data

IMMUNOBIOLOGY

MicroRNAs activate natural killer cells through Toll-like receptor signaling
Shun He,Jianhong Chu,Lai-Chu Wu,Hsiaoyin Mao,Yong Peng,Christopher A. Alvarez-Breckenridge,Tiffany Hughes,Min Wei,Jianying Zhang,Shunzong Yuan,Sumeet Sandhu,Sumithira Vasu,Don M. Benson, Jr,Craig C. Hofmeister,Xiaoming He,Kalpana Ghoshal,Steven M. Devine,Michael A. Caligiuri,Jianhua Yu
View Articletitled, MicroRNAs activate natural killer cells through Toll-like receptor signaling
Supplemental data
LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity
Konrad Krzewski,Aleksandra Gil-Krzewska,Victoria Nguyen,Giovanna Peruzzi,John E. Coligan
View Articletitled, LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity
Supplemental data
TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy
Olga Hennion-Tscheltzoff,Dominique Leboeuf,Simon-David Gauthier,Martine Dupuis,Brigitte Assouline,Anne Grégoire,Stéphanie Thiant,Martin Guimond
View Articletitled, TCR triggering modulates the responsiveness and homeostatic proliferation of CD4<sup>+</sup> thymic emigrants to IL-7 therapy
Supplemental data
Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity
Dominika Rudnicka,Anna Oszmiana,Donna K. Finch,Ian Strickland,Darren J. Schofield,David C. Lowe,Matthew A. Sleeman,Daniel M. Davis
View Articletitled, Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity
Supplemental data
Influence of KIR gene copy number on natural killer cell education
Brief Report
Vivien Béziat,James A. Traherne,Lisa L. Liu,Jyothi Jayaraman,Monika Enqvist,Stella Larsson,John Trowsdale,Karl-Johan Malmberg
View Articletitled, Influence of KIR gene copy number on natural killer cell education
Supplemental data

LYMPHOID NEOPLASIA

Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells
Carsten Zwick,Natalie Fadle,Evi Regitz,Maria Kemele,Stephan Stilgenbauer,Andreas Bühler,Michael Pfreundschuh,Klaus-Dieter Preuss
View Articletitled, Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells
Supplemental data
Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma
Changju Qu,Yadong Liu,Kranthi Kunkalla,Rajesh R. Singh,Marzenna Blonska,Xin Lin,Nitin Kumar Agarwal,Francisco Vega
View Articletitled, Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma
Supplemental data
Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex
Jillian F. Wise,Zuzana Berkova,Rohit Mathur,Haifeng Zhu,Frank K. Braun,Rong-Hua Tao,Anita L. Sabichi,Xue Ao,Hoyoung Maeng,Felipe Samaniego
View Articletitled, Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex
Supplemental data
CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma
James L. Rubenstein,Valerie S. Wong,Cigall Kadoch,Hua-Xin Gao,Ramon Barajas,Lingjing Chen,S. Andrew Josephson,Brian Scott,Vanja Douglas,Mekhala Maiti,Lawrence D. Kaplan,Patrick A. Treseler,Soonmee Cha,Jimmy H. Hwang,Paola Cinque,Jason G. Cyster,Clifford Lowell
View Articletitled, CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma
Supplemental data
Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations
Brief Report
Martin Neumann,Sandra Heesch,Cornelia Schlee,Stefan Schwartz,Nicola Gökbuget,Dieter Hoelzer,Nikola P. Konstandin,Bianka Ksienzyk,Sebastian Vosberg,Alexander Graf,Stefan Krebs,Helmut Blum,Thorsten Raff,Monika Brüggemann,Wolf-Karsten Hofmann,Jochen Hecht,Stefan K. Bohlander,Philipp A. Greif,Claudia D. Baldus
View Articletitled, Whole-exome sequencing in adult ETP-ALL reveals a high rate of <em>DNMT3A</em> mutations
Supplemental data
Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma
Brief Report
Saad Z. Usmani,Jeffrey Sawyer,Adam Rosenthal,Michele Cottler-Fox,Joshua Epstein,Shmuel Yaccoby,Rachael Sexton,Antje Hoering,Zeba Singh,Christoph J. Heuck,Sarah Waheed,Nabeel Chauhan,Donald Johann,Al-Ola Abdallah,Jameel Muzaffar,Nathan Petty,Clyde Bailey,John Crowley,Frits van Rhee,Bart Barlogie
View Articletitled, Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma
Supplemental data

MYELOID NEOPLASIA

A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesis
Amanda E. Conway,Paula B. Scotland,Catherine P. Lavau,Daniel S. Wechsler
View Articletitled, A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesis
Supplemental data
Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG)
Verena I. Gaidzik,Richard F. Schlenk,Peter Paschka,Anja Stölzle,Daniela Späth,Andrea Kuendgen,Marie von Lilienfeld-Toal,Wolfram Brugger,Hans Günter Derigs,Stephan Kremers,Richard Greil,Aruna Raghavachar,Mark Ringhoffer,Helmut R. Salih,Mohammed Wattad,Heinz G. Kirchen,Volker Runde,Gerhard Heil,Andreas L. Petzer,Michael Girschikofsky,Michael Heuser,Sabine Kayser,Gudrun Goehring,Maria-Veronica Teleanu,Brigitte Schlegelberger,Arnold Ganser,Jürgen Krauter,Lars Bullinger,Hartmut Döhner,Konstanze Döhner
View Articletitled, Clinical impact of <em>DNMT3A</em> mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG)
Supplemental data
Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project
Brief Report
Giovanni Barosi,Ruben Mesa,Guido Finazzi,Claire Harrison,Jean-Jacques Kiladjian,Eva Lengfelder,Mary F. McMullin,Francesco Passamonti,Alessandro M. Vannucchi,Carlos Besses,Heinz Gisslinger,Jan Samuelsson,Srdan Verstovsek,Ronald Hoffman,Animesh Pardanani,Francisco Cervantes,Ayalew Tefferi,Tiziano Barbui
View Articletitled, Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project

PLATELETS AND THROMBOPOIESIS

Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia
Soames Boyle,Richard H. White,Ann Brunson,Ted Wun
View Articletitled, Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia

RED CELLS, IRON, AND ERYTHROPOIESIS

Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23
Maria Liljeholm,Andrew F. Irvine,Ann-Louise Vikberg,Anna Norberg,Stacy Month,Herbert Sandström,Anders Wahlin,Masanori Mishima,Irina Golovleva
View Articletitled, Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, <em>KIF23</em>
Supplemental data

TRANSPLANTATION

The impact of HLA unidirectional mismatches on the outcome of myeloablative hematopoietic stem cell transplantation with unrelated donors
Carolyn Katovich Hurley,Ann Woolfrey,Tao Wang,Michael Haagenson,John Umejiego,Mahmoud Aljurf,Medhat Askar,Minoo Battiwalla,Jason Dehn,John Horan,Machteld Oudshoorn,Joseph Pidala,Wael Saber,Victoria Turner,Stephanie J. Lee,Stephen R. Spellman
View Articletitled, The impact of HLA unidirectional mismatches on the outcome of myeloablative hematopoietic stem cell transplantation with unrelated donors

CORRESPONDENCE

Development of Hodgkin lymphoma in homozygotic triplets with constitutional deletion in MKL1
Magnus Björkholm,Jan Sjöberg,Ulla Axdorph Nygell,Anna Porwit,Erik Björck
View Articletitled, Development of Hodgkin lymphoma in homozygotic triplets with constitutional deletion in <em>MKL1</em>
Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype
Kyle M. Walsh,Adam J. de Smith,Anand P. Chokkalingam,Catherine Metayer,Gary V. Dahl,Ling-i Hsu,Lisa F. Barcellos,Joseph L. Wiemels,Patricia A. Buffler
View Articletitled, Novel childhood ALL susceptibility locus <em>BMI1-PIP4K2A</em> is specifically associated with the hyperdiploid subtype
Gender influences the birth order effect in HLA-identical stem cell transplantation
Miranda P. Dierselhuis,Eric Spierings,Ronald Brand,Matthijs Hendriks,Angelica Canossi,Harry Dolstra,Jean-François Eliaou,Jürgen Enczmann,Thibaut Gervais,Brigitte Kircher,David Laurin,Pascale Loiseau,Ruhena Sergeant,Els Goulmy
View Articletitled, Gender influences the birth order effect in HLA-identical stem cell transplantation
  • Cover Image

    Cover Image

    issue cover

    The cover confocal microscopy image shows murine embryonic fibroblasts (MEFs) expressing mutated CALM-AF10 lacking the hydrophobic residues of the CALM-derived nuclear export signal (NES). Mutant CALM-AF10 is detected with an anti-Flag primary antibody and 568-conjugated anti-mouse secondary antibody (red), and nuclei are stained with DAPI (blue). Although CALM-AF10 normally localizes to the cytoplasm, point mutation of the NES prevents nuclear export and results in exclusive nuclear localization of CALM-AF10. The authors determine the CALM-derived NES is necessary and sufficient for CALM-AF10-mediated leukemogenesis, emphasizing a critical role for the nuclear export pathway in these leukemias. See the article by Conway et al on page 4758.

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