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Trastuzumab for treatment of refractory/relapsed HER2-positive adult B-ALL: results of a phase 2 GRAALL study
CBL mutation in chronic myelomonocytic leukemia secondary to familial platelet disorder with propensity to develop acute myeloid leukemia (FPD/AML)
Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML
Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study
Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation
The Dynamic International Prognostic Scoring System for myelofibrosis predicts outcomes after hematopoietic cell transplantation
Long-term outcomes after transplantation of HLA-identical related G-CSF–mobilized peripheral blood mononuclear cells versus bone marrow
Issue Archive
March 15 2012
In this Issue
Table of Contents
Inside Blood
Blood Work
Review Articles
How I Treat
Clinical Trials and Observations
Hematopoiesis and Stem Cells
S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release
Karin Golan,Yaron Vagima,Aya Ludin,Tomer Itkin,Shiri Cohen-Gur,Alexander Kalinkovich,Orit Kollet,Chihwa Kim,Amir Schajnovitz,Yossi Ovadya,Kfir Lapid,Shoham Shivtiel,Andrew J. Morris,Mariusz Z. Ratajczak,Tsvee Lapidot
Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2
Stephen B. Ting,Eric Deneault,Kristin Hope,Sonia Cellot,Jalila Chagraoui,Nadine Mayotte,Jonas F. Dorn,Jean-Philippe Laverdure,Michael Harvey,Edwin D. Hawkins,Sarah M. Russell,Paul S. Maddox,Norman N. Iscove,Guy Sauvageau
Immunobiology
Lymphoid Neoplasia
Trastuzumab for treatment of refractory/relapsed HER2-positive adult B-ALL: results of a phase 2 GRAALL study
Brief Report
Patrice Chevallier,Nelly Robillard,Aude Charbonnier,Emmanuel Raffoux,Sebastien Maury,Sylvain Carras,Cecile Chabrot,Cecile Fohrer,Marc Bernard,Jean-Sebastien Blade,Anne Etienne,Pascaline Talmant,Jacques Delaunay,Thierry Guillaume,Mohamad Mohty,Marie-Christine Bene,Norbert Ifrah,Herve Dombret
Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes
Fabien Guilloton,Gersende Caron,Cédric Ménard,Céline Pangault,Patricia Amé-Thomas,Joëlle Dulong,John De Vos,Delphine Rossille,Catherine Henry,Thierry Lamy,Olivier Fouquet,Thierry Fest,Karin Tarte
Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma
Loredana Santo,Teru Hideshima,Andrew L. Kung,Jen-Chieh Tseng,David Tamang,Min Yang,Matthew Jarpe,John H. van Duzer,Ralph Mazitschek,Walter C. Ogier,Diana Cirstea,Scott Rodig,Homare Eda,Tyler Scullen,Miriam Canavese,James Bradner,Kenneth C. Anderson,Simon S. Jones,Noopur Raje
Myeloid Neoplasia
CBL mutation in chronic myelomonocytic leukemia secondary to familial platelet disorder with propensity to develop acute myeloid leukemia (FPD/AML)
Brief Report
Norio Shiba,Daisuke Hasegawa,Myoung-ja Park,Chisato Murata,Aiko Sato-Otsubo,Chitose Ogawa,Atsushi Manabe,Hirokazu Arakawa,Seishi Ogawa,Yasuhide Hayashi
Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML
e-blood
Shinsuke Hirabayashi,Christian Flotho,Jessica Moetter,Michael Heuser,Henrik Hasle,Bernd Gruhn,Thomas Klingebiel,Felicitas Thol,Brigitte Schlegelberger,Irith Baumann,Brigitte Strahm,Jan Stary,Franco Locatelli,Marco Zecca,Eva Bergstraesser,Michael Dworzak,Marry M. van den Heuvel-Eibrink,Barbara De Moerloose,Seishi Ogawa,Charlotte M. Niemeyer,Marcin W. Wlodarski,on behalf of the European Working Group of MDS in Childhood
Phagocytes, Granulocytes, and Myelopoiesis
Red Cells, Iron, and Erythropoiesis
Thrombosis and Hemostasis
Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study
Clinical Trials & Observations
Jean-Christophe Gris,Sylvie Bouvier,Nicolas Molinari,Jean-Philippe Galanaud,Éva Cochery-Nouvellon,Érik Mercier,Pascale Fabbro-Peray,Jean-Pierre Balducchi,Pierre Marès,Isabelle Quéré,Michel Dauzat
Transplantation
Transplant tolerance is associated with reduced expression of cystathionine-γ-lyase that controls IL-12 production by dendritic cells and TH-1 immune responses
Romain Vuillefroy de Silly,Flora Coulon,Nicolas Poirier,Vojislav Jovanovic,Sophie Brouard,Véronique Ferchaud-Roucher,Gilles Blancho,Bernard Vanhove
Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation
Clinical Trials & Observations
Ekaterina Doubrovina,Banu Oflaz-Sozmen,Susan E. Prockop,Nancy A. Kernan,Sara Abramson,Julie Teruya-Feldstein,Cyrus Hedvat,Joanne F. Chou,Glenn Heller,Juliet N. Barker,Farid Boulad,Hugo Castro-Malaspina,Diane George,Ann Jakubowski,Guenther Koehne,Esperanza B. Papadopoulos,Andromachi Scaradavou,Trudy N. Small,Ramzi Khalaf,James W. Young,Richard J. O'Reilly
The Dynamic International Prognostic Scoring System for myelofibrosis predicts outcomes after hematopoietic cell transplantation
Clinical Trials & Observations
Bart L. Scott,Ted A. Gooley,Mohamed L. Sorror,Andrew R. Rezvani,Michael L. Linenberger,Jonathan Grim,Brenda M. Sandmaier,David Myerson,Thomas R. Chauncey,Rainer Storb,Veronika Buxhofer-Ausch,Jerald P. Radich,Frederick R. Appelbaum,H. Joachim Deeg
Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function
Bree Foley,Sarah Cooley,Michael R. Verneris,Michelle Pitt,Julie Curtsinger,Xianghua Luo,Sandra Lopez-Vergès,Lewis L. Lanier,Daniel Weisdorf,Jeffrey S. Miller
Long-term outcomes after transplantation of HLA-identical related G-CSF–mobilized peripheral blood mononuclear cells versus bone marrow
Brief Report
Marco Mielcarek,Barry Storer,Paul J. Martin,Stephen J. Forman,Robert S. Negrin,Mary E. Flowers,Yoshihiro Inamoto,Thomas R. Chauncey,Rainer Storb,Frederick R. Appelbaum,William I. Bensinger
Vascular Biology
BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis
Hidetaka Ohnuki,Hirofumi Inoue,Nobuaki Takemori,Hironao Nakayama,Tomohisa Sakaue,Shinji Fukuda,Daisuke Miwa,Eiji Nishiwaki,Masahiko Hatano,Takeshi Tokuhisa,Yaeta Endo,Masato Nose,Shigeki Higashiyama
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Cover Image
Cover Image
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Asymmetric cell division as a mechanism for hematopoietic stem cell (HSC) self-renewal remains enigmatic. The endocytic gene, Ap2a2, is shown to impact upon HSC self-renewal while also demonstrating asymmetric segregation during real-time videomicroscopy. In these still images taken from a videomicroscopy of a CD150+48− LSK stem cell transduced with a cherry-Ap2a2 fluorescent fusion, Ap2a2 is seen to clearly localize at one polar side during telophase, and then asymmetrically segregate into only one daughter cell after cytokinesis. See Figure 7 and supplemental videos in the article by Ting et al on page 2510.
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