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Issue Archive

Volume 113, Issue 12
March 19 2009
Issue Cover

Table of Contents

INSIDE BLOOD

INSIDE BLOOD
Unraveling ALK signaling through phosphoproteomics
Megan S. Lim
View Articletitled, Unraveling ALK signaling through phosphoproteomics
PHAGOCYTES & GRANULOCYTES
The expanding universe of the basophil
Michael F. Gurish
View Articletitled, The expanding universe of the basophil
PLATELETS & THROMBOPOIESIS
To give and take — life of a platelet
Jan Palmblad
View Articletitled, To give and take — life of a platelet

REVIEW ARTICLES

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome
Sébastien Malinge,Shai Izraeli,John D. Crispino
View Articletitled, Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

CLINICAL TRIALS AND OBSERVATIONS

Age-related Epstein-Barr virus (EBV)–associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients
Clinical Trials & Observations
Naoko Asano,Kazuhito Yamamoto,Jun-Ichi Tamaru,Takashi Oyama,Fumihiro Ishida,Koichi Ohshima,Tadashi Yoshino,Naoya Nakamura,Shigeo Mori,Osamu Yoshie,Yoshie Shimoyama,Yasuo Morishima,Tomohiro Kinoshita,Shigeo Nakamura
View Articletitled, Age-related Epstein-Barr virus (EBV)–associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients
Supplemental data
Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
Clinical Trials & Observations
Mitch A. Phelps,Thomas S. Lin,Amy J. Johnson,Eunju Hurh,Darlene M. Rozewski,Katherine L. Farley,Di Wu,Kristie A. Blum,Beth Fischer,Sarah M. Mitchell,Mollie E. Moran,Michelle Brooker-McEldowney,Nyla A. Heerema,David Jarjoura,Larry J. Schaaf,John C. Byrd,Michael R. Grever,James T. Dalton
View Articletitled, Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia

GENE THERAPY

A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation
Xiufen Zheng,Costin Vladau,Xusheng Zhang,Motohiko Suzuki,Thomas E. Ichim,Zhu-Xu Zhang,Mu Li,Ewa Carrier,Bertha Garcia,Anthony M. Jevnikar,Wei-Ping Min
View Articletitled, A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Distinct roles of stress-activated protein kinases in Fanconi anemia type C–deficient hematopoiesis
M. Reza Saadatzadeh,Khadijeh Bijangi-Vishehsaraei,Reuben Kapur,Laura S. Haneline
View Articletitled, Distinct roles of stress-activated protein kinases in Fanconi anemia type C–deficient hematopoiesis
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle
Alex J. Tipping,Cristina Pina,Anders Castor,Dengli Hong,Neil P. Rodrigues,Lorenza Lazzari,Gillian E. May,Sten Eirik W. Jacobsen,Tariq Enver
View Articletitled, High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle
Supplemental data

IMMUNOBIOLOGY

Antigen-loaded exosomes alone induce Th1-type memory through a B cell–dependent mechanism
Khaleda Rahman Qazi,Ulf Gehrmann,Emilie Domange Jordö,Mikael C. I. Karlsson,Susanne Gabrielsson
View Articletitled, Antigen-loaded exosomes alone induce Th1-type memory through a B cell–dependent mechanism
Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry
Takashi Miwa,Lin Zhou,Yuko Kimura,David Kim,Avinash Bhandoola,Wen-Chao Song
View Articletitled, Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry
Supplemental data
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
Jayme D. Allen,Zahara M. Jaffer,Su-Jung Park,Sarah Burgin,Clemens Hofmann,Mary Ann Sells,Shi Chen,Ethel Derr-Yellin,Elizabeth G. Michels,Andrew McDaniel,Waylan K. Bessler,David A. Ingram,Simon J. Atkinson,Jeffrey B. Travers,Jonathan Chernoff,D. Wade Clapp
View Articletitled, p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
Supplemental data
Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells
Don M. Benson, Jr,Jianhua Yu,Brian Becknell,Min Wei,Aharon G. Freud,Amy K. Ferketich,Rossana Trotta,Danilo Perrotti,Roger Briesewitz,Michael A. Caligiuri
View Articletitled, Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells
Hypomethylating drugs convert HA-1–negative solid tumors into targets for stem cell–based immunotherapy
Lothar Hambach,Kam-Wing Ling,Jos Pool,Zohara Aghai,Els Blokland,Hans J. Tanke,Jan A. Bruijn,Hans Halfwerk,Hester van Boven,Brigitte Wieles,Els Goulmy
View Articletitled, Hypomethylating drugs convert HA-1–negative solid tumors into targets for stem cell–based immunotherapy
Supplemental data
VEGF-mediated cross-talk within the neonatal murine thymus
Andrew R. Cuddihy,Shundi Ge,Judy Zhu,Julie Jang,Ann Chidgey,Gavin Thurston,Richard Boyd,Gay M. Crooks
View Articletitled, VEGF-mediated cross-talk within the neonatal murine thymus
Supplemental data
Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway
Nuria Izquierdo-Useros,Mar Naranjo-Gómez,Jacob Archer,Steven C. Hatch,Itziar Erkizia,Julià Blanco,Francesc E. Borràs,Maria Carmen Puertas,John H. Connor,Maria Teresa Fernández-Figueras,Landon Moore,Bonaventura Clotet,Suryaram Gummuluru,Javier Martinez-Picado
View Articletitled, Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway
Supplemental data
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival
Brief Report
Mohamed Lamkanfi,Lilian O. Moreira,Patrudu Makena,Diana C. J. Spierings,Kelli Boyd,Peter J. Murray,Douglas R. Green,Thirumala-Devi Kanneganti
View Articletitled, Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival

LYMPHOID NEOPLASIA

Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models
Melanie G. Cornejo,Michael G. Kharas,Miriam B. Werneck,Séverine Le Bras,Sandra A. Moore,Brian Ball,Marie Beylot-Barry,Scott J. Rodig,Jon C. Aster,Benjamin H. Lee,Harvey Cantor,Jean-Philippe Merlio,D. Gary Gilliland,Thomas Mercher
View Articletitled, Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models
Supplemental data
Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-κB
Tiejun Zhao,Jun-ichirou Yasunaga,Yorifumi Satou,Mitsuyoshi Nakao,Masahiko Takahashi,Masahiro Fujii,Masao Matsuoka
View Articletitled, Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-κB
Supplemental data
Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome
Bruno Chetaille,François Bertucci,Pascal Finetti,Benjamin Esterni,Aspasia Stamatoullas,Jean Michel Picquenot,Marie Christine Copin,Frank Morschhauser,Olivier Casasnovas,Tony Petrella,Thierry Molina,Anne Vekhoff,Pierre Feugier,Reda Bouabdallah,Daniel Birnbaum,Daniel Olive,Luc Xerri
View Articletitled, Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome
Supplemental data
The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL
Francesco E. Boccalatte,Claudia Voena,Chiara Riganti,Amalia Bosia,Lucia D'Amico,Ludovica Riera,Mangeng Cheng,Bruce Ruggeri,Ole N. Jensen,Valerie L. Goss,Kimberly Lee,Julie Nardone,John Rush,Roberto D. Polakiewicz,Michael J. Comb,Roberto Chiarle,Giorgio Inghirami
View Articletitled, The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL
Supplemental data
PKCβ is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCβ as a therapeutic target in chronic lymphocytic leukemia
Brief Report
Claudia Holler,Josefina D. Piñón,Ursula Denk,Christoph Heyder,Sebastian Hofbauer,Richard Greil,Alexander Egle
View Articletitled, PKCβ is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCβ as a therapeutic target in chronic lymphocytic leukemia
Supplemental data

MYELOID NEOPLASIA

Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features
Maria E. Figueroa,Bas J. Wouters,Lucy Skrabanek,Jacob Glass,Yushan Li,Claudia A. J. Erpelinck-Verschueren,Anton W. Langerak,Bob Löwenberg,Melissa Fazzari,John M. Greally,Peter J. M. Valk,Ari Melnick,Ruud Delwel
View Articletitled, Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
Desiree A. Steimer,Kelli Boyd,Osamu Takeuchi,Jill K. Fisher,Gerard P. Zambetti,Joseph T. Opferman
View Articletitled, Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
Supplemental data
Basophil effector function and homeostasis during helminth infection
Caspar Ohnmacht,David Voehringer
View Articletitled, Basophil effector function and homeostasis during helminth infection
Supplemental data

PLATELETS AND THROMBOPOIESIS

Role for MKL1 in megakaryocytic maturation
Ee-chun Cheng,Qing Luo,Emanuela M. Bruscia,Matthew J. Renda,James A. Troy,Stephanie A. Massaro,David Tuck,Vincent Schulz,Shrikant M. Mane,Nancy Berliner,Yi Sun,Stephan W. Morris,Caihong Qiu,Diane S. Krause
View Articletitled, Role for MKL1 in megakaryocytic maturation
Supplemental data
Platelets actively sequester angiogenesis regulators
Giannoula Lakka Klement,Tai-Tung Yip,Flavia Cassiola,Lena Kikuchi,David Cervi,Vladimir Podust,Joseph E. Italiano,Erin Wheatley,Abdo Abou-Slaybi,Elise Bender,Nava Almog,Mark W. Kieran,Judah Folkman
View Articletitled, Platelets actively sequester angiogenesis regulators
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Transferrin-a modulates hepcidin expression in zebrafish embryos
Paula G. Fraenkel,Yann Gibert,Jason L. Holzheimer,Victoria J. Lattanzi,Sarah F. Burnett,Kimberly A. Dooley,Rebecca A. Wingert,Leonard I. Zon
View Articletitled, Transferrin-a modulates hepcidin expression in zebrafish embryos
Supplemental data

TRANSPLANTATION

HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism
Takakazu Kawase,Keitaro Matsuo,Koichi Kashiwase,Hidetoshi Inoko,Hiroh Saji,Seishi Ogawa,Shunichi Kato,Takehiko Sasazuki,Yoshihisa Kodera,Yasuo Morishima,for The Japan Marrow Donor Program
View Articletitled, HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism
Supplemental data

VASCULAR BIOLOGY

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality
Frank Niessen,Christian Furlan-Freguia,José A. Fernández,Laurent O. Mosnier,Francis J. Castellino,Hartmut Weiler,Hugh Rosen,John H. Griffin,Wolfram Ruf
View Articletitled, Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

CORRESPONDENCE

Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7
Ingrid Furlan,Christiane Batz,Christian Flotho,Brigitte Mohr,Michael Lübbert,Meinolf Suttorp,Charlotte M. Niemeyer
View Articletitled, Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7
Etanercept for treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation
Haydar Frangoul,Tatsuki Koyama,Jennifer Domm
View Articletitled, Etanercept for treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation
Response: Etanercept for idiopathic pneumonia syndrome
Gregory Yanik,Kenneth Cooke
View Articletitled, Response: Etanercept for idiopathic pneumonia syndrome
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