Skip Nav Destination
Phase 3 randomized, placebo-controlled, double-blind study of high-dose continuous infusion cytarabine alone or with laromustine (VNP40101M) in patients with acute myeloid leukemia in first relapse
Wild-type FOXP3 is selectively active in CD4+CD25hi regulatory T cells of healthy female carriers of different FOXP3 mutations
Issue Archive
November 5 2009
In this Issue
Table of Contents
INSIDE BLOOD
BLOOD WORK
PLENARY PAPERS
Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal
Michael Heuser,Laura M. Sly,Bob Argiropoulos,Florian Kuchenbauer,Courteney Lai,Andrew Weng,Malina Leung,Grace Lin,Christy Brookes,Stephen Fung,Peter J. Valk,Ruud Delwel,Bob Löwenberg,Gerald Krystal,R. Keith Humphries
REVIEW ARTICLES
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
Phase 3 randomized, placebo-controlled, double-blind study of high-dose continuous infusion cytarabine alone or with laromustine (VNP40101M) in patients with acute myeloid leukemia in first relapse
Clinical Trials & Observations
Francis Giles,Norbert Vey,Daniel DeAngelo,Karen Seiter,Wendy Stock,Robert Stuart,Darinka Boskovic,Arnaud Pigneux,Martin Tallman,Joseph Brandwein,Jonathan Kell,Tadeusz Robak,Peter Staib,Xavier Thomas,Ann Cahill,Maher Albitar,Susan O'Brien
GENE THERAPY
CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII–specific immune responses in plasmid-mediated gene therapy–treated hemophilia mice
Carol H. Miao,Benjamin R. Harmeling,Steven F. Ziegler,Benjamin C. Yen,Troy Torgerson,Liping Chen,Roger J. Yau,Baowei Peng,Arthur R. Thompson,Hans D. Ochs,David J. Rawlings
HEMATOPOIESIS AND STEM CELLS
Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction
Michael L. Chen,T. Daniel Logan,Maryann L. Hochberg,Suresh G. Shelat,Xiang Yu,Gregory E. Wilding,Wei Tan,Gregory C. Kujoth,Tomas A. Prolla,Mary A. Selak,Mondira Kundu,Martin Carroll,James E. Thompson
Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis
Sonia Rodriguez,Angelo Chora,Boyan Goumnerov,Christen Mumaw,W. Scott Goebel,Luis Fernandez,Hasan Baydoun,Harm HogenEsch,David M. Dombkowski,Carol A. Karlewicz,Susan Rice,Laurence G. Rahme,Nadia Carlesso
IMMUNOBIOLOGY
Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction
Emanuela Marcenaro,Claudia Cantoni,Silvia Pesce,Carola Prato,Daniela Pende,Sophie Agaugué,Lorenzo Moretta,Alessandro Moretta
Different NK cell–activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity
Stephanie M. Wood,Marie Meeths,Samuel C. C. Chiang,Anne Grete Bechensteen,Jaap J. Boelens,Carsten Heilmann,Hisanori Horiuchi,Steen Rosthøj,Olga Rutynowska,Jacek Winiarski,Jennifer L. Stow,Magnus Nordenskjöld,Jan-Inge Henter,Hans-Gustaf Ljunggren,Yenan T. Bryceson
The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency
Allen K. L. Cheung,David J. Gottlieb,Bodo Plachter,Sandra Pepperl-Klindworth,Selmir Avdic,Anthony L. Cunningham,Allison Abendroth,Barry Slobedman
Wild-type FOXP3 is selectively active in CD4+CD25hi regulatory T cells of healthy female carriers of different FOXP3 mutations
Brief Report
Sara Di Nunzio,Massimiliano Cecconi,Laura Passerini,Alicia N. McMurchy,Udo Baron,Ivana Turbachova,Silvia Vignola,Erica Valencic,Alberto Tommasini,Anne Junker,Giantonio Cazzola,Sven Olek,Megan K. Levings,Lucia Perroni,Maria Grazia Roncarolo,Rosa Bacchetta
LYMPHOID NEOPLASIA
Eμ-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-κB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma
Zhaoyang Li,Hongsheng Wang,Liquan Xue,Dong-Mi Shin,Derry Roopenian,Wu Xu,Chen-Feng Qi,Mark Y. Sangster,Carlos J. Orihuela,Elaine Tuomanen,Jerold E. Rehg,Xiaoli Cui,Quangeng Zhang,Herbert C. Morse, III,Stephan W. Morris
MYELOID NEOPLASIA
E3 ligase–defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease
Srinivasa Rao Bandi,Christian Brandts,Marion Rensinghoff,Rebekka Grundler,Lara Tickenbrock,Gabriele Köhler,Justus Duyster,Wolfgang E. Berdel,Carsten Müller-Tidow,Hubert Serve,on behalf of the Study Alliance Leukemias,Bülent Sargin
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
A fundamental role of mAbp1 in neutrophils: impact on β2 integrin–mediated phagocytosis and adhesion in vivo
Jürgen Schymeinsky,Ronald Gerstl,Ingrid Mannigel,Katy Niedung,David Frommhold,Klaus Panthel,Jürgen Heesemann,Michael Sixt,Thomas Quast,Waldemar Kolanus,Attila Mocsai,Jürgen Wienands,Markus Sperandio,Barbara Walzog
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSFUSION MEDICINE
TRANSPLANTATION
Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation
Ann M. Leen,Anne Christin,Gary D. Myers,Hao Liu,Conrad R. Cruz,Patrick J. Hanley,Alana A. Kennedy-Nasser,Kathryn S. Leung,Adrian P. Gee,Robert A. Krance,Malcolm K. Brenner,Helen E. Heslop,Cliona M. Rooney,Catherine M. Bollard
Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units
Michael R. Verneris,Claudio G. Brunstein,Juliet Barker,Margaret L. MacMillan,Todd DeFor,David H. McKenna,Michael J. Burke,Bruce R. Blazar,Jeffrey S. Miller,Philip B. McGlave,Daniel J. Weisdorf,John E. Wagner
VASCULAR BIOLOGY
Bone marrow stem and progenitor cell contribution to neovasculogenesis is dependent on model system with SDF-1 as a permissive trigger
Gerard J. Madlambayan,Jason M. Butler,Koji Hosaka,Marda Jorgensen,Dongtao Fu,Steven M. Guthrie,Anitha K. Shenoy,Adam Brank,Kathryn J. Russell,Jaclyn Otero,Dietmar W. Siemann,Edward W. Scott,Christopher R. Cogle
CORRESPONDENCE
-
Cover Image
Cover Image
![issue cover]()
The cover shows confocal spinning disc microscopy of a neutrophil-like differentiated HL-60 cell expressing mAbp1-EGFP during β2 integrin–mediated phagocytosis of serum-opsonized Alexa 594–conjugated E coli. Consecutive images at indicated time points were extracted from the original recording that was performed with a frame rate of one picture per second. For better visualization, the EGFP fluorescence intensity was processed to pseudocolors. mAbp1 was dynamically enriched at the binding site of the E coli particle (dotted line). See the article by Schymeinsky et al on page 4209 and the supplemental video available online.
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkBack Matter
- PDF Icon PDF LinkAdvertising
- PDF Icon PDF LinkEditorial Board
Advertisement intended for health care professionals
Email alerts
Advertisement intended for health care professionals
