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Volume 102, Issue 2

July 15 2003

In this Issue

INSIDE BLOOD
PLENARY PAPERS
ERRATA
PERSPECTIVES
REVIEW ARTICLES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

Jump-starting immune reconstitution after stem cell transplantation

Kenneth I. Weinberg

View Articletitled, Jump-starting immune reconstitution after stem cell transplantation

DDAVP and interleukin-11: a boosting combination

Peter J. Lenting,Jan J. Sixma

View Articletitled, DDAVP and interleukin-11: a boosting combination

Another advance for globin gene therapy

David M. Bodine

View Articletitled, Another advance for globin gene therapy

Collagen-mediated platelet activation and PI3K

Charles S. Abrams

View Articletitled, Collagen-mediated platelet activation and PI3K

The biology and treatment of ITP: what's next?

Steven E. McKenzie

View Articletitled, The biology and treatment of ITP: what's next?

Angiopoietin expression in multiple myeloma

William T. Bellamy

View Articletitled, Angiopoietin expression in multiple myeloma

Use of FLT3 inhibitors in leukemia: a wrench in the activation loop

D. Gary Gilliland

View Articletitled, Use of FLT3 inhibitors in leukemia: a wrench in the activation loop

Hematopoietic cells for targeting iatrogenic immunomodulation

William M. Nauseef

View Articletitled, Hematopoietic cells for targeting iatrogenic immunomodulation

Peptidoglycan recognition and neutrophil function

Jerrold Weiss

View Articletitled, Peptidoglycan recognition and neutrophil function

PLENARY PAPERS

Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation

Caroline Arber,Andrew BitMansour,Timothy E. Sparer,John P. Higgins,Edward S. Mocarski,Irving L. Weissman,Judith A. Shizuru,Janice M. Y. Brown

View Articletitled, Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation

Impaired thymic negative selection causes autoimmune graft-versus-host disease

Takanori Teshima,Pavan Reddy,Chen Liu,Debra Williams,Kenneth R. Cooke,James L. M. Ferrara

View Articletitled, Impaired thymic negative selection causes autoimmune graft-versus-host disease

Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP)

Eva H. N. Olsen,Arlene S. McCain,Elizabeth P. Merricks,Thomas H. Fischer,Ivy M. Dillon,Robin A. Raymer,Dwight A. Bellinger,Scot A. Fahs,Robert R. Montgomery,James C. Keith, Jr,Robert G. Schaub,Timothy C. Nichols

View Articletitled, Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP)

ERRATA

Erratum for vol. 101, p. 1653

View Articletitled, Erratum for vol. 101, p. 1653

PERSPECTIVES

New designs for phase 2 clinical trials
Clinical Trials & Observations

Elihu H. Estey,Peter F. Thall

View Articletitled, New designs for phase 2 clinical trials

REVIEW ARTICLES

Platelet-collagen interaction: is GPVI the central receptor?

Bernhard Nieswandt,Steve P. Watson

View Articletitled, Platelet-collagen interaction: is GPVI the central receptor?

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Prognosis of inv(16)/t(16;16) acute myeloid leukemia (AML): a survey of 110 cases from the French AML Intergroup
Clinical Trials & Observations

Jacques Delaunay,Norbert Vey,Thierry Leblanc,Pierre Fenaux,Françoise Rigal-Huguet,Francis Witz,Thierry Lamy,Anne Auvrignon,Didier Blaise,Arnaud Pigneux,Francine Mugneret,Christian Bastard,Nicole Dastugue,Jacqueline Van den Akker,Denis Fière,Josy Reiffers,Sylvie Castaigne,Guy Leverger,Jean-Luc Harousseau,Hervé Dombret,for the French Acute Myeloid Leukemia (AML) Intergroup including the Groupe Ouest-Est des Leucémies Aiguës Myéloblastiques (GOELAM), the Leucémies Aiguës Myéloblastiques de l'Enfant (LAME), the Acute Leukemia French Association (ALFA), and the Bordeaux-Grenoble-Marseille-Toulouse (BGMT) cooperative groups

View Articletitled, Prognosis of inv(16)/t(16;16) acute myeloid leukemia (AML): a survey of 110 cases from the French AML Intergroup

Graft-versus-host disease following allogeneic transplantation from HLA-identical sibling with antithymocyte globulin–based reduced-intensity preparative regimen
Clinical Trials & Observations

Mohamad Mohty,Jacques-Olivier Bay,Catherine Faucher,Bachra Choufi,Karin Bilger,Olivier Tournilhac,Norbert Vey,Anne-Marie Stoppa,Diane Coso,Christian Chabannon,Patrice Viens,Dominique Maraninchi,Didier Blaise

View Articletitled, Graft-versus-host disease following allogeneic transplantation from HLA-identical sibling with antithymocyte globulin–based reduced-intensity preparative regimen

Melphalan-mobilized blood stem cell components contain minimal clonotypic myeloma cell contamination
Clinical Trials & Observations Brief Report

Ping Zhou,Yana Zhang,Carmen Martinez,Nagesh Kalakonda,Stephen D. Nimer,Raymond L. Comenzo

View Articletitled, Melphalan-mobilized blood stem cell components contain minimal clonotypic myeloma cell contamination

GENE THERAPY

Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway

Andrew M. Davidoff,Catherine Y. C. Ng,Junfang Zhou,Yunyu Spence,Amit C. Nathwani

View Articletitled, Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway

Genetically targeted radiotherapy for multiple myeloma

David Dingli,Rosa Maria Diaz,Elizabeth R. Bergert,Michael K. O'Connor,John C. Morris,Stephen J. Russell

View Articletitled, Genetically targeted radiotherapy for multiple myeloma

Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence

Simona Cavalieri,Sabrina Cazzaniga,Massimo Geuna,Zulma Magnani,Claudio Bordignon,Luigi Naldini,Chiara Bonini

View Articletitled, Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence

Successful treatment of murine β-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

Derek A. Persons,Esther R. Allay,Nobukuni Sawai,Phillip W. Hargrove,Thomas P. Brent,Hideki Hanawa,Arthur W. Nienhuis,Brian P. Sorrentino

View Articletitled, Successful treatment of murine β-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

HEMATOPOIESIS

Severe telomere shortening in patients with paroxysmal nocturnal hemoglobinuria affects both GPI^– and GPI⁺ hematopoiesis
Brief Report

Anastasios Karadimitris,David J. Araten,Lucio Luzzatto,Rosario Notaro

View Articletitled, Severe telomere shortening in patients with paroxysmal nocturnal hemoglobinuria affects both GPI– and GPI+ hematopoiesis

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
Brief Report

Richard C. Allsopp,Gregg B. Morin,Ronald DePinho,Calvin B. Harley,Irving L. Weissman

View Articletitled, Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

The heme-heme oxygenase system: a molecular switch in wound healing

Frank A. D. T. G. Wagener,Hugo E. van Beurden,Johannes W. von den Hoff,Gosse J. Adema,Carl G. Figdor

View Articletitled, The heme-heme oxygenase system: a molecular switch in wound healing

Asp1424Asn MYH9 mutation results in an unstable protein responsible for the phenotypes in May-Hegglin anomaly/Fechtner syndrome

Samuel Deutsch,Alexandra Rideau,Marie-Luce Bochaton-Piallat,Giuseppe Merla,Antoine Geinoz,Giulio Gabbiani,Torsten Schwede,Thomas Matthes,Stylianos E. Antonarakis,Photis Beris

View Articletitled, Asp1424Asn MYH9 mutation results in an unstable protein responsible for the phenotypes in May-Hegglin anomaly/Fechtner syndrome

Fibrinogen gamma-chain splice variant γ′ alters fibrin formation and structure

Amy V. Cooper,Kristina F. Standeven,Robert A. S. Ariëns

View Articletitled, Fibrinogen gamma-chain splice variant γ′ alters fibrin formation and structure

Functional phenotype of phosphoinositide 3-kinase p85α-null platelets characterized by an impaired response to GP VI stimulation

Naohide Watanabe,Hideaki Nakajima,Hidenori Suzuki,Atsushi Oda,Yumiko Matsubara,Masaaki Moroi,Yasuo Terauchi,Takashi Kadowaki,Harumi Suzuki,Shigeo Koyasu,Yasuo Ikeda,Makoto Handa

View Articletitled, Functional phenotype of phosphoinositide 3-kinase p85α-null platelets characterized by an impaired response to GP VI stimulation

Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease

Lee A. O'Brien,Paula D. James,Maha Othman,Ergul Berber,Cherie Cameron,Colleen R. P. Notley,Carol A. Hegadorn,Jeffrey J. Sutherland,Christine Hough,Georges E. Rivard,Denise O'Shaunessey,David Lillicrap,the Association of Hemophilia Clinic Directors of Canada

View Articletitled, Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease

IVIg-mediated amelioration of murine ITP via FcγRIIB is independent of SHIP1, SHP-1, and Btk activity
Brief Report

Andrew R. Crow,Seng Song,John Freedman,Cheryl D. Helgason,R. Keith Humphries,Katherine A. Siminovitch,Alan H. Lazarus

View Articletitled, IVIg-mediated amelioration of murine ITP via FcγRIIB is independent of SHIP1, SHP-1, and Btk activity

Factor VII gene intronic mutation in a lethal factor VII deficiency: effects on splice-site selection
Brief Report

Keren Borensztajn,Marie-Laure Sobrier,Anne-Marie Fischer,Ouerdia Chafa,Serge Amselem,Jacqueline Tapon-Bretaudiére

View Articletitled, Factor VII gene intronic mutation in a lethal factor VII deficiency: effects on splice-site selection

IMMUNOBIOLOGY

Selective blockade of CD28 and not CTLA-4 with a single-chain Fv–α₁-antitrypsin fusion antibody

Bernard Vanhove,Geneviève Laflamme,Flora Coulon,Marie Mougin,Patricia Vusio,Fabienne Haspot,Jérôme Tiollier,Jean-Paul Soulillou

View Articletitled, Selective blockade of CD28 and not CTLA-4 with a single-chain Fv–α1-antitrypsin fusion antibody

Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells

Susanne M. Schmidt,Kerstin Schag,Martin R. Müller,Markus M. Weck,Silke Appel,Lothar Kanz,Frank Grünebach,Peter Brossart

View Articletitled, Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells

Low frequency of CD94/NKG2A⁺ T lymphocytes in patients with HTLV-1–associated myelopathy/tropical spastic paraparesis, but not in asymptomatic carriers
Clinical Trials & Observations

Mineki Saito,Veronique M. Braud,Peter Goon,Emmanuel Hanon,Graham P. Taylor,Akiko Saito,Nobutaka Eiraku,Yuetsu Tanaka,Koichiro Usuku,Jonathan N. Weber,Mitsuhiro Osame,Charles R. M. Bangham

View Articletitled, Low frequency of CD94/NKG2A+ T lymphocytes in patients with HTLV-1–associated myelopathy/tropical spastic paraparesis, but not in asymptomatic carriers

Ontogeny and innate properties of neonatal dendritic cells

Cheng-Ming Sun,Laurence Fiette,Myriam Tanguy,Claude Leclerc,Richard Lo-Man

View Articletitled, Ontogeny and innate properties of neonatal dendritic cells

Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation

Karin Tarte,Fenghuang Zhan,John De Vos,Bernard Klein,John Shaughnessy, Jr

View Articletitled, Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation

Supplemental data

CD8α⁺ mouse spleen dendritic cells do not originate from the CD8α^- dendritic cell subset

Shalin Naik,David Vremec,Li Wu,Meredith O'Keeffe,Ken Shortman

View Articletitled, CD8α+ mouse spleen dendritic cells do not originate from the CD8α- dendritic cell subset

Therapeutic effect of idiotype-specific CD4⁺ T cells against B-cell lymphoma in the absence of anti-idiotypic antibodies

Katrin U. Lundin,Peter O. Hofgaard,Hilde Omholt,Ludvig A. Munthe,Alexandre Corthay,Bjarne Bogen

View Articletitled, Therapeutic effect of idiotype-specific CD4+ T cells against B-cell lymphoma in the absence of anti-idiotypic antibodies

ATP gradients inhibit the migratory capacity of specific human dendritic cell types: implications for P2Y₁₁ receptor signaling

Max Schnurr,Tracey Toy,Patrizia Stoitzner,Paul Cameron,Amanda Shin,Tina Beecroft,Ian D. Davis,Jonathan Cebon,Eugene Maraskovsky

View Articletitled, ATP gradients inhibit the migratory capacity of specific human dendritic cell types: implications for P2Y11 receptor signaling

The minor histocompatibility antigen HA-3 arises from differential proteasome–mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein

Eric Spierings,Anthony G. Brickner,Jennifer A. Caldwell,Suzanne Zegveld,Nia Tatsis,Els Blokland,Jos Pool,Richard A. Pierce,Sahana Mollah,Jeffrey Shabanowitz,Laurence C. Eisenlohr,Peter Van Veelen,Ferry Ossendorp,Donald F. Hunt,Els Goulmy,Victor H. Engelhard

View Articletitled, The minor histocompatibility antigen HA-3 arises from differential proteasome–mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein

NEOPLASIA

Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia

Stefan Faderl,David Harris,Quin Van,Hagop M. Kantarjian,Moshe Talpaz,Zeev Estrov

View Articletitled, Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia

Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis

Nicola Giuliani,Simona Colla,Mirca Lazzaretti,Roberto Sala,Giovanni Roti,Cristina Mancini,Sabrina Bonomini,Paolo Lunghi,Magda Hojden,Giovenzio Genestreti,Mirija Svaldi,Paolo Coser,Pier Paolo Fattori,Gabriella Sammarelli,Gian Carlo Gazzola,Regis Bataille,Camillo Almici,Cecilia Caramatti,Lina Mangoni,Vittorio Rizzoli

View Articletitled, Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis

Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor

Rebekka Grundler,Christian Thiede,Cornelius Miething,Christine Steudel,Christian Peschel,Justus Duyster

View Articletitled, Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8–mediated apoptosis and down-regulation of c-FLIP protein

Jennifer L. Aron,Mark R. Parthun,Guido Marcucci,Shinichi Kitada,Andrew P. Mone,Melanie E. Davis,Tiansheng Shen,Timothy Murphy,Joseph Wickham,Chris Kanakry,David M. Lucas,John C. Reed,Michael R. Grever,John C. Byrd

View Articletitled, Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8–mediated apoptosis and down-regulation of c-FLIP protein

Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph⁺ acute lymphoblastic leukemia
Brief Report

Wolf-Karsten Hofmann,Martina Komor,Barbara Wassmann,Letetia C. Jones,Harald Gschaidmeier,Dieter Hoelzer,H. Phillip Koeffler,Oliver G. Ottmann

View Articletitled, Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia

PHAGOCYTES

Oxidative stress is a critical mediator of the angiotensin II signal in human neutrophils: involvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-κB

Rajaa El Bekay,Moisés Álvarez,Javier Monteseirín,Gonzalo Álba,Pedro Chacón,Antonio Vega,José Martín-Nieto,Juan Jiménez,Elízabeth Pintado,Francisco J. Bedoya,Francisco Sobrino

View Articletitled, Oxidative stress is a critical mediator of the angiotensin II signal in human neutrophils: involvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-κB

Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites

Damien Chaussabel,Roshanak Tolouei Semnani,Mary Ann McDowell,David Sacks,Alan Sher,Thomas B. Nutman

View Articletitled, Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites

Supplemental data

Sorting of soluble TNF-receptor for granule storage in hematopoietic cells as a principle for targeting of selected proteins to inflamed sites

Ying Gao,Hanna Rosén,Ellinor Johnsson,Jero Calafat,Hans Tapper,Inge Olsson

View Articletitled, Sorting of soluble TNF-receptor for granule storage in hematopoietic cells as a principle for targeting of selected proteins to inflamed sites

Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)–deficient mice

Roman Dziarski,Kenneth A. Platt,Eva Gelius,Håkan Steiner,Dipika Gupta

View Articletitled, Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)–deficient mice

RED CELLS

A promoter mutation in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene causes X-linked sideroblastic anemia

Soumeya Bekri,Alison May,Philip D. Cotter,Ala I. Al-Sabah,Xiaojun Guo,Gillian S. Masters,David F. Bishop

View Articletitled, A promoter mutation in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene causes X-linked sideroblastic anemia

Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum

Fausta Omodeo-Salè,Anna Motti,Nicoletta Basilico,Silvia Parapini,Piero Olliaro,Donatella Taramelli

View Articletitled, Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum

The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation

Wulin Aerbajinai,Mara Giattina,Y. Terry Lee,Mark Raffeld,Jeffery L. Miller

View Articletitled, The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation

Single-chain antibody fragments derived from a human synthetic phage-display library bind thrombospondin and inhibit sickle cell adhesion

Nicholas A. Watkins,Lily M. Du,J. Paul Scott,Willem H. Ouwehand,Cheryl A. Hillery

View Articletitled, Single-chain antibody fragments derived from a human synthetic phage-display library bind thrombospondin and inhibit sickle cell adhesion

A novel missense mutation in the γ-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production
Clinical Trials & Observations

David Hamilton,Jian Hui Wu,Moulay Alaoui-Jamali,Gerald Batist

View Articletitled, A novel missense mutation in the γ-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production

TRANSFUSION MEDICINE

Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP^- neutrophils from NB1 GP–expressing individuals and association of low expression with NB1 gene polymorphisms
Brief Report

Jens Wolff,Cornelia Brendel,Ludger Fink,Rainer M. Bohle,Karin Kissel,Juergen Bux

View Articletitled, Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP–expressing individuals and association of low expression with NB1 gene polymorphisms

TRANSPLANTATION

G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases

Anke Franzke,Wenji Piao,Jörg Lauber,Patricia Gatzlaff,Christian Könecke,Wiebke Hansen,Angela Schmitt-Thomsen,Bernd Hertenstein,Jan Buer,Arnold Ganser

View Articletitled, G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases

Transient expansion of Mac1⁺Ly6-G⁺Ly6-C⁺ early myeloid cells with suppressor activity in spleens of murine radiation marrow chimeras: possible implications for the graft-versus-host and graft-versus-leukemia reactivity of donor lymphocyte infusions

An D. Billiau,Sabine Fevery,Omer Rutgeerts,Willy Landuyt,Mark Waer

View Articletitled, Transient expansion of Mac1+Ly6-G+Ly6-C+ early myeloid cells with suppressor activity in spleens of murine radiation marrow chimeras: possible implications for the graft-versus-host and graft-versus-leukemia reactivity of donor lymphocyte infusions

Long-term remission in mantle cell lymphoma following high-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting (R-HDS regimen)

Alessandro M. Gianni,Michele Magni,Maurizio Martelli,Massimo Di Nicola,Carmelo Carlo-Stella,Silvana Pilotti,Alessandro Rambaldi,Sergio Cortelazzo,Caterina Patti,Guido Parvis,Fabio Benedetti,Saveria Capria,Paolo Corradini,Corrado Tarella,Tiziano Barbui

View Articletitled, Long-term remission in mantle cell lymphoma following high-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting (R-HDS regimen)

Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation
Clinical Trials & Observations

Marco Mielcarek,Paul J. Martin,Wendy Leisenring,Mary E. D. Flowers,David G. Maloney,Brenda M. Sandmaier,Michael B. Maris,Rainer Storb

View Articletitled, Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation

Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays

Tamotsu Ichiba,Takanori Teshima,Rork Kuick,David E. Misek,Chen Liu,Yuichiro Takada,Yoshinobu Maeda,Pavan Reddy,Debra L. Williams,Samir M. Hanash,James L. M. Ferrara

View Articletitled, Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays

CORRESPONDENCE

Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients

Obiageli N. Onwuazor,Xiao-Yan Wen,Ding-Yan Wang,Lihua Zhuang,Esther Masih-Khan,Jaimie Claudio,Bart Barlogie,John D. Shaughnessy, Jr,A. Keith Stewart

View Articletitled, Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients

Usefulness of quantitative assessment of the WT1 gene transcript as a marker for minimal residual disease detection

Daniela Cilloni,Enrico Gottardi,Milena Fava,Francesca Messa,Sonia Carturan,Alessandro Busca,Angelo Guerrasio,Giuseppe Saglio

View Articletitled, Usefulness of quantitative assessment of the WT1 gene transcript as a marker for minimal residual disease detection

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

ERRATA

PERSPECTIVES

New designs for phase 2 clinical trials Clinical Trials & Observations

REVIEW ARTICLES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Prognosis of inv(16)/t(16;16) acute myeloid leukemia (AML): a survey of 110 cases from the French AML Intergroup Clinical Trials & Observations

Graft-versus-host disease following allogeneic transplantation from HLA-identical sibling with antithymocyte globulin–based reduced-intensity preparative regimen Clinical Trials & Observations

Melphalan-mobilized blood stem cell components contain minimal clonotypic myeloma cell contamination Clinical Trials & Observations Brief Report

GENE THERAPY

HEMATOPOIESIS

Severe telomere shortening in patients with paroxysmal nocturnal hemoglobinuria affects both GPI– and GPI+ hematopoiesis Brief Report

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IVIg-mediated amelioration of murine ITP via FcγRIIB is independent of SHIP1, SHP-1, and Btk activity Brief Report

Factor VII gene intronic mutation in a lethal factor VII deficiency: effects on splice-site selection Brief Report