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Issue Archive

Volume 109, Issue 11
June 1 2007
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS
Pumping out platelets
Douglas B. Cines
View Articletitled, Pumping out platelets
CLINICAL TRIALS AND OBSERVATIONS
No more transplantation in CML?
Clinical Trials & Observations
François Guilhot
View Articletitled, No more transplantation in CML?
CLINICAL TRIALS AND OBSERVATIONS
PD-1+ T cells: exhausted and premature?
Clinical Trials & Observations
Lishan Su
View Articletitled, PD-1<sup>+</sup> T cells: exhausted and premature?
CLINICAL TRIALS AND OBSERVATIONS
How low can you go: quality effects of an anti-CD4 antibody
Clinical Trials & Observations
Ellen J. Kim,Alain H. Rook
View Articletitled, How low can you go: quality effects of an anti-CD4 antibody
GENE THERAPY
Altruistic donor T cells
Pierre Tiberghien
View Articletitled, Altruistic donor T cells
CLINICAL TRIALS AND OBSERVATIONS
Inhibitors in hemophilia: nature or nurture?
Clinical Trials & Observations
Thomas Abshire
View Articletitled, Inhibitors in hemophilia: nature or nurture?
HEMATOPOIESIS
Trading muscle iron for erythropoiesis at high altitude
Chaim Hershko
View Articletitled, Trading muscle iron for erythropoiesis at high altitude

BLOOD WORK

Adult T-cell leukemia/lymphoma
View Articletitled, Adult T-cell leukemia/lymphoma

PLENARY PAPERS

Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival
Adrian Wiestner,Mahsa Tehrani,Michael Chiorazzi,George Wright,Federica Gibellini,Kazutaka Nakayama,Hui Liu,Andreas Rosenwald,H. Konrad Muller-Hermelink,German Ott,Wing C. Chan,Timothy C. Greiner,Dennis D. Weisenburger,Julie Vose,James O. Armitage,Randy D. Gascoyne,Joseph M. Connors,Elias Campo,Emilio Montserrat,Francesc Bosch,Erlend B. Smeland,Stein Kvaloy,Harald Holte,Jan Delabie,Richard I. Fisher,Thomas M. Grogan,Thomas P. Miller,Wyndham H. Wilson,Elaine S. Jaffe,Louis M. Staudt,for the Lymphoma/Leukemia Molecular Profiling Project
View Articletitled, Point mutations and genomic deletions in <em>CCND1</em> create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival

ERRATUM

Erratum for Vlasáková et al., Histone deacetylase inhibitors suppress IFNα-induced up-regulation of promyelocytic leukemia protein
View Articletitled, Erratum for Vlasáková et al., Histone deacetylase inhibitors suppress IFNα-induced up-regulation of promyelocytic leukemia protein
Erratum for Fraser et al entitled Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression
View Articletitled, Erratum for Fraser et al entitled Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression

REVIEW ARTICLES

New thrombopoietic growth factors
David J. Kuter
View Articletitled, New thrombopoietic growth factors

HOW I TREAT

How I treat indolent lymphoma
John G. Gribben
View Articletitled, How I treat indolent lymphoma

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

The peritoneal micromilieu commits B cells to home to body cavities and the small intestine
Simon Berberich,Reinhold Förster,Oliver Pabst
View Articletitled, The peritoneal micromilieu commits B cells to home to body cavities and the small intestine

CLINICAL TRIALS AND OBSERVATIONS

Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFRA–positive chronic eosinophilic leukemia
Clinical Trials & Observations
Jelena V. Jovanovic,Joannah Score,Katherine Waghorn,Daniela Cilloni,Enrico Gottardi,Georgia Metzgeroth,Philipp Erben,Helena Popp,Christoph Walz,Andreas Hochhaus,Catherine Roche-Lestienne,Claude Preudhomme,Ellen Solomon,Jane Apperley,Michela Rondoni,Emanuela Ottaviani,Giovanni Martinelli,Finella Brito-Babapulle,Giuseppe Saglio,Rüdiger Hehlmann,Nicholas C. P. Cross,Andreas Reiter,David Grimwade,on behalf of the European LeukemiaNet
View Articletitled, Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in <em>FIP1L1-PDGFRA</em>–positive chronic eosinophilic leukemia
Supplemental data
Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study
Clinical Trials & Observations
Henrik Hasle,Todd A. Alonzo,Anne Auvrignon,Catherine Behar,Myron Chang,Ursula Creutzig,Alexandra Fischer,Erik Forestier,Alcira Fynn,Oskar A. Haas,Jochen Harbott,Christine J. Harrison,Nyla A. Heerema,Marry M. van den Heuvel-Eibrink,Gertjan J. L. Kaspers,Franco Locatelli,Peter Noellke,Sophia Polychronopoulou,Yaddanapudi Ravindranath,Bassem Razzouk,Dirk Reinhardt,Natalia N. Savva,Batia Stark,Stefan Suciu,Ichiro Tsukimoto,David K. Webb,Dorora Wojcik,William G. Woods,Martin Zimmermann,Charlotte M. Niemeyer,Susana C. Raimondi
View Articletitled, Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study
Supplemental data
Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study
Clinical Trials & Observations
Samantha C. Gouw,Johanna G. van der Bom,H. Marijke van den Berg,for the CANAL Study group
View Articletitled, Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study
Supplemental data
Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma
Clinical Trials & Observations
Youn H. Kim,Madeleine Duvic,Erik Obitz,Robert Gniadecki,Lars Iversen,Anders Österborg,Sean Whittaker,Timothy M. Illidge,Thomas Schwarz,Roland Kaufmann,Kevin Cooper,Kim M. Knudsen,Steen Lisby,Ole Baadsgaard,Susan J. Knox
View Articletitled, Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma
Racial variation in the relationship of anemia with mortality and mobility disability among older adults
Clinical Trials & Observations
Kushang V. Patel,Tamara B. Harris,Marion Faulhaber,Sara B. Angleman,Stephanie Connelly,Douglas C. Bauer,Lewis H. Kuller,Anne B. Newman,Jack M. Guralnik,for the Health, Aging, and Body Composition Study
View Articletitled, Racial variation in the relationship of anemia with mortality and mobility disability among older adults
Supplemental data
PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors
Clinical Trials & Observations
Ji-Yuan Zhang,Zheng Zhang,Xicheng Wang,Jun-Liang Fu,Jinxia Yao,Yanmei Jiao,Liangen Chen,Hui Zhang,Jianan Wei,Lei Jin,Ming Shi,George Fu Gao,Hao Wu,Fu-Sheng Wang
View Articletitled, PD-1 up-regulation is correlated with HIV-specific memory CD8<sup>+</sup> T-cell exhaustion in typical progressors but not in long-term nonprogressors
Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia
Clinical Trials & Observations
William G. Wierda,Susan O'Brien,Xuemei Wang,Stefan Faderl,Alessandra Ferrajoli,Kim-Anh Do,Jorge Cortes,Deborah Thomas,Guillermo Garcia-Manero,Charles Koller,Miloslav Beran,Francis Giles,Farhad Ravandi,Susan Lerner,Hagop Kantarjian,Michael Keating
View Articletitled, Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia
Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia
Clinical Trials & Observations
Rüdiger Hehlmann,Ute Berger,Markus Pfirrmann,Hermann Heimpel,Andreas Hochhaus,Joerg Hasford,Hans-Jochem Kolb,Tanja Lahaye,Ole Maywald,Andreas Reiter,Dieter K. Hossfeld,Christoph Huber,Helmut Löffler,Hans Pralle,Wolfgang Queisser,Andreas Tobler,Christoph Nerl,Max Solenthaler,Mariele E. Goebeler,Martin Griesshammer,Thomas Fischer,Stephan Kremers,Hartmut Eimermacher,Michael Pfreundschuh,Wolf-Dietrich Hirschmann,Klaus Lechner,Barbara Wassmann,Christiane Falge,Hartmut H. Kirchner,Alois Gratwohl,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group
View Articletitled, Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia
Supplemental data
Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort study
Clinical Trials & Observations
Samantha C. Gouw,Johanna G. van der Bom,Günter Auerswald,Carmen Escuriola Ettinghausen,Ulf Tedgård,H. Marijke van den Berg,for the CANAL Study group,for the CANAL Study group,for the CANAL Study group,for the CANAL Study group,for the CANAL Study group,for the CANAL Study group
View Articletitled, Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort study
Supplemental data

GENE THERAPY

Antitumor effects of HSV-TK–engineered donor lymphocytes after allogeneic stem-cell transplantation
Fabio Ciceri,Chiara Bonini,Sarah Marktel,Elisabetta Zappone,Paolo Servida,Massimo Bernardi,Alessandra Pescarollo,Attilio Bondanza,Jacopo Peccatori,Silvano Rossini,Zulma Magnani,Monica Salomoni,Claudia Benati,Maurilio Ponzoni,Luciano Callegaro,Paolo Corradini,Marco Bregni,Catia Traversari,Claudio Bordignon
View Articletitled, Antitumor effects of HSV-TK–engineered donor lymphocytes after allogeneic stem-cell transplantation
The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies
Catia Traversari,Sarah Marktel,Zulma Magnani,Patrizia Mangia,Vincenzo Russo,Fabio Ciceri,Chiara Bonini,Claudio Bordignon
View Articletitled, The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies

HEMATOPOIESIS

G-CSF treatment of severe congenital neutropenia reverses neutropenia but does not correct the underlying functional deficiency of the neutrophil in defending against microorganisms
Marta Donini,Stefania Fontana,Gianfranco Savoldi,William Vermi,Laura Tassone,Francesca Gentili,Elena Zenaro,Daniela Ferrari,Lucia D. Notarangelo,Fulvio Porta,Fabio Facchetti,Luigi D. Notarangelo,Stefano Dusi,Raffaele Badolato
View Articletitled, G-CSF treatment of severe congenital neutropenia reverses neutropenia but does not correct the underlying functional deficiency of the neutrophil in defending against microorganisms
Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle
Paul Robach,Gaetano Cairo,Cecilia Gelfi,Francesca Bernuzzi,Henriette Pilegaard,Agnese Viganò,Paolo Santambrogio,Paolo Cerretelli,José A. L. Calbet,Stéphane Moutereau,Carsten Lundby
View Articletitled, Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle
Evidence that the Pim1 kinase gene is a direct target of HOXA9
Yu-Long Hu,Emmanuelle Passegué,Stephen Fong,Corey Largman,Hugh Jeffrey Lawrence
View Articletitled, Evidence that the <em>Pim1</em> kinase gene is a direct target of HOXA9
Supplemental data
Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
Brief Report
Julian M. Jenkins,Daphne Williams,Yanli Deng,Joanne Uhl,Valerie Kitchen,David Collins,Connie L. Erickson-Miller
View Articletitled, Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure
Femke Zwerts,Florea Lupu,Astrid De Vriese,Saskia Pollefeyt,Lieve Moons,Rachel A. Altura,Yuying Jiang,Patrick H. Maxwell,Peter Hill,Hideyasu Oh,Claus Rieker,Désiré Collen,Simon J. Conway,Edward M. Conway
View Articletitled, Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure
Supplemental data
Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
Jeffrey S. Scehnet,Weidong Jiang,S. Ram Kumar,Valery Krasnoperov,Alexandre Trindade,Rui Benedito,Dusan Djokovic,Cristina Borges,Eric J. Ley,Antonio Duarte,Parkash S. Gill
View Articletitled, Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
Supplemental data
In vivo vasculogenic potential of human blood-derived endothelial progenitor cells
Juan M. Melero-Martin,Zia A. Khan,Arnaud Picard,Xiao Wu,Sailaja Paruchuri,Joyce Bischoff
View Articletitled, In vivo vasculogenic potential of human blood-derived endothelial progenitor cells
Supplemental data
Regulation of protein C inhibitor (PCI) activity by specific oxidized and negatively charged phospholipids
Julia M. Malleier,Olga Oskolkova,Valery Bochkov,Ingrid Jerabek,Barbora Sokolikova,Thomas Perkmann,Johannes Breuss,Bernd R. Binder,Margarethe Geiger
View Articletitled, Regulation of protein C inhibitor (PCI) activity by specific oxidized and negatively charged phospholipids
Supplemental data
Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment
Stefan Amatschek,Ernst Kriehuber,Wolfgang Bauer,Barbel Reininger,Paul Meraner,Alois Wolpl,Norbert Schweifer,Christian Haslinger,Georg Stingl,Dieter Maurer
View Articletitled, Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment
Supplemental data
Moderation of the platelet releasate response by aspirin
Judith A. Coppinger,Roisin O'Connor,Kieran Wynne,Michelle Flanagan,Matthew Sullivan,Patricia B. Maguire,Desmond J. Fitzgerald,Gerard Cagney
View Articletitled, Moderation of the platelet releasate response by aspirin
Supplemental data
Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells
Tri Minh Bui Nguyen,Indira V. Subramanian,Ameeta Kelekar,Sundaram Ramakrishnan
View Articletitled, Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells
Supplemental data
Platelet-bound lipopolysaccharide enhances Fc receptor–mediated phagocytosis of IgG-opsonized platelets
Brief Report
John W. Semple,Rukhsana Aslam,Michael Kim,Edwin R. Speck,John Freedman
View Articletitled, Platelet-bound lipopolysaccharide enhances Fc receptor–mediated phagocytosis of IgG-opsonized platelets
The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro
Brief Report
Stephen A. Newland,Iain C. Macaulay,Andres R. Floto,Edwin C. de Vet,Willem H. Ouwehand,Nicholas A. Watkins,Paul A. Lyons,Duncan R. Campbell
View Articletitled, The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro
Supplemental data

IMMUNOBIOLOGY

Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation
Ruth R. French,Vadim Y. Taraban,Graham R. Crowther,Tania F. Rowley,Juliet C. Gray,Peter W. Johnson,Alison L. Tutt,Aymen Al-Shamkhani,Martin J. Glennie
View Articletitled, Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation
Supplemental data
Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors
Pearlie K. Epling-Burnette,Fanqi Bai,Jeffrey S. Painter,Dana E. Rollison,Helmut R. Salih,Matthias Krusch,JianXiang Zou,Edna Ku,Bin Zhong,David Boulware,Lynn Moscinski,Sheng Wei,Julie Y. Djeu,Alan F. List
View Articletitled, Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors
Supplemental data
Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors
Robert S. Welner,Rosana Pelayo,Karla P. Garrett,Xinrong Chen,S. Scott Perry,Xiao-Hong Sun,Barbara L. Kee,Paul W. Kincade
View Articletitled, Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kit<sup>Hi</sup>CD62L<sup>+</sup> lymphoid progenitors
Supplemental data
HIV-1–specific CTLs effectively suppress replication of HIV-1 in HIV-1–infected macrophages
Mamoru Fujiwara,Masafumi Takiguchi
View Articletitled, HIV-1–specific CTLs effectively suppress replication of HIV-1 in HIV-1–infected macrophages
Bortezomib enhances dendritic cell (DC)–mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications
Radek Spisek,Anna Charalambous,Amitabha Mazumder,David H. Vesole,Sundar Jagannath,Madhav V. Dhodapkar
View Articletitled, Bortezomib enhances dendritic cell (DC)–mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications
Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections
Nobuhiro Nakano,Chiharu Nishiyama,Shunsuke Kanada,Yusuke Niwa,Naomi Shimokawa,Hiroko Ushio,Makoto Nishiyama,Ko Okumura,Hideoki Ogawa
View Articletitled, Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections
T cell–dependent survival of CD20+ and CD20− plasma cells in human secondary lymphoid tissue
David R. Withers,Claudia Fiorini,Randy T. Fischer,Rachel Ettinger,Peter E. Lipsky,Amrie C. Grammer
View Articletitled, T cell–dependent survival of CD20<sup>+</sup> and CD20<sup>−</sup> plasma cells in human secondary lymphoid tissue
Supplemental data
Adoptive transfer of tumor-primed, in vitro–activated, CD4+ T effector cells (TEs) combined with CD8+ TEs provides intratumoral TE proliferation and synergistic antitumor response
Li-Xin Wang,Suyu Shu,Mary L. Disis,Gregory E. Plautz
View Articletitled, Adoptive transfer of tumor-primed, in vitro–activated, CD4<sup>+</sup> T effector cells (T<sub>E</sub>s) combined with CD8<sup>+</sup> T<sub>E</sub>s provides intratumoral T<sub>E</sub> proliferation and synergistic antitumor response
Functional characterization of natural killer cells in type I leukocyte adhesion deficiency
Roberta Castriconi,Alessandra Dondero,Claudia Cantoni,Mariella Della Chiesa,Carola Prato,Marina Nanni,Maurilia Fiorini,Lucia Notarangelo,Silvia Parolini,Lorenzo Moretta,Luigi Notarangelo,Alessandro Moretta,Cristina Bottino
View Articletitled, Functional characterization of natural killer cells in type I leukocyte adhesion deficiency
CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype
Yuwen Zhu,Gefeng Zhu,Liqun Luo,Andrew S. Flies,Lieping Chen
View Articletitled, CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

NEOPLASIA

Monoclonal TCR-Vβ13.1+/CD4+/NKa+/CD8−/+dim T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin
Pilar Garrido,Francisco Ruiz-Cabello,Paloma Bárcena,Yorick Sandberg,Julia Cantón,Margarida Lima,Ana Balanzategui,Marcos González,Miguel Angel López-Nevot,Anton W. Langerak,Andrés C. García-Montero,Julia Almeida,Alberto Orfao
View Articletitled, Monoclonal TCR-Vβ13.1<sup>+</sup>/CD4<sup>+</sup>/NKa<sup>+</sup>/CD8<sup>−/+dim</sup> T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin
Development of a murine model for blastoid variant mantle-cell lymphoma
Richard J. Ford,Long Shen,Yen Chiu Lin-Lee,Lan V. Pham,Asha Multani,Hai-Jun Zhou,Archito T. Tamayo,ChongJie Zhang,Lesleyann Hawthorn,John K. Cowell,Julian L. Ambrus, Jr
View Articletitled, Development of a murine model for blastoid variant mantle-cell lymphoma
Supplemental data
Endogenous bcl-2 is not required for the development of Eμ-myc–induced B-cell lymphoma
Priscilla N. Kelly,Hamsa Puthalakath,Jerry M. Adams,Andreas Strasser
View Articletitled, Endogenous <em>bcl-2</em> is not required for the development of Eμ-<em>myc</em>–induced B-cell lymphoma
Supplemental data
Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma
Karène Mahtouk,Dirk Hose,Pierre Raynaud,Michael Hundemer,Michel Jourdan,Eric Jourdan,Veronique Pantesco,Marion Baudard,John De Vos,Marion Larroque,Thomas Moehler,Jean-Francois Rossi,Thierry Rème,Hartmut Goldschmidt,Bernard Klein
View Articletitled, Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma
The myeloproliferative disorder–associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3
Michelle B. Hookham,Joanne Elliott,Yvonne Suessmuth,Judith Staerk,Alister C. Ward,William Vainchenker,Melanie J. Percy,Mary Frances McMullin,Stefan N. Constantinescu,James A. Johnston
View Articletitled, The myeloproliferative disorder–associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3
Supplemental data
Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy
Heidi Nyman,Magdalena Adde,Marja-Liisa Karjalainen-Lindsberg,Minna Taskinen,Mattias Berglund,Rose-Marie Amini,Carl Blomqvist,Gunilla Enblad,Sirpa Leppä
View Articletitled, Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy
Supplemental data
p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors
Duonan Yu,Martin Carroll,Andrei Thomas-Tikhonenko
View Articletitled, p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia
Valerio Fulci,Sabina Chiaretti,Marina Goldoni,Gianluca Azzalin,Nicoletta Carucci,Simona Tavolaro,Leandro Castellano,Armando Magrelli,Franca Citarella,Monica Messina,Roberta Maggio,Nadia Peragine,Simona Santangelo,Francesca Romana Mauro,Pablo Landgraf,Thomas Tuschl,David B. Weir,Minchen Chien,James J. Russo,Jingyue Ju,Robert Sheridan,Chris Sander,Mihaela Zavolan,Anna Guarini,Robin Foà,Giuseppe Macino
View Articletitled, Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia
Supplemental data
The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells
Laurence de Leval,David S. Rickman,Caroline Thielen,Aurélien de Reynies,Yen-Lin Huang,Georges Delsol,Laurence Lamant,Karen Leroy,Josette Brière,Thierry Molina,Françoise Berger,Christian Gisselbrecht,Luc Xerri,Philippe Gaulard
View Articletitled, The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (T<sub>FH</sub>) cells
Supplemental data
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenström macroglobulinemia
Anne-Sophie Moreau,Xiaoying Jia,Hai T. Ngo,Xavier Leleu,Garrett O'Sullivan,Yazan Alsayed,Alexey Leontovich,Klaus Podar,Jeffrey Kutok,John Daley,Suzan Lazo-Kallanian,Evdoxia Hatjiharissi,Marc S. Raab,Lian Xu,Steven P. Treon,Teru Hideshima,Kenneth C. Anderson,Irene M. Ghobrial
View Articletitled, Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenström macroglobulinemia
CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia
Pär Josefsson,Christian H. Geisler,Henrik Leffers,Jørgen H. Petersen,Mette K. Andersen,Jesper Jurlander,Anne Mette Buhl
View Articletitled, <em>CLLU1</em> expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia
Comparative biodistributions of pretargeted radioimmunoconjugates targeting CD20, CD22, and DR molecules on human B-cell lymphomas
Anastasia Pantelias,John M. Pagel,Nathan Hedin,Laura Saganic,Shani Wilbur,Donald K. Hamlin,D. Scott Wilbur,Yukang Lin,Diane Stone,Don Axworthy,Ajay K. Gopal,Oliver W. Press
View Articletitled, Comparative biodistributions of pretargeted radioimmunoconjugates targeting CD20, CD22, and DR molecules on human B-cell lymphomas
The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy
Sergio Caffieri,Fabio Di Lisa,Federico Bolesani,Monica Facco,Gianpietro Semenzato,Francesco Dall'Acqua,Marcella Canton
View Articletitled, The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy
CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms
Fenghuang Zhan,Simona Colla,Xiaosong Wu,Bangzheng Chen,James P. Stewart,W. Michael Kuehl,Bart Barlogie,John D. Shaughnessy, Jr
View Articletitled, <em>CKS1B</em>, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27<sup>Kip1</sup>-dependent and -independent mechanisms
CD28-mediated regulation of multiple myeloma cell proliferation and survival
Nizar J. Bahlis,Anne M. King,Despina Kolonias,Louise M. Carlson,Hong Yu Liu,Mohamad A. Hussein,Howard R. Terebelo,Gerald E. Byrne, Jr,Bruce L. Levine,Lawrence H. Boise,Kelvin P. Lee
View Articletitled, CD28-mediated regulation of multiple myeloma cell proliferation and survival
Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study
Arghya Ray,Sandra W. Cowan-Jacob,Paul W. Manley,Jürgen Mestan,James D. Griffin
View Articletitled, Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study
Supplemental data
Hsp90 regulates the Fanconi anemia DNA damage response pathway
Tsukasa Oda,Toshiya Hayano,Hidenobu Miyaso,Nobuhiro Takahashi,Takayuki Yamashita
View Articletitled, Hsp90 regulates the Fanconi anemia DNA damage response pathway

RED CELLS

Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin
Sara Gardenghi,Maria F. Marongiu,Pedro Ramos,Ella Guy,Laura Breda,Amy Chadburn,YiFang Liu,Ninette Amariglio,Gideon Rechavi,Eliezer A. Rachmilewitz,William Breuer,Z. Ioav Cabantchik,Diedra M. Wrighting,Nancy C. Andrews,Maria de Sousa,Patricia J. Giardina,Robert W. Grady,Stefano Rivella
View Articletitled, Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin
Supplemental data
Highly homologous T-cell receptor beta sequences support a common target for autoreactive T cells in most patients with paroxysmal nocturnal hemoglobinuria
Lucia Gargiulo,Sonia Lastraioli,Giannamaria Cerruti,Martina Serra,Fabrizio Loiacono,Simona Zupo,Lucio Luzzatto,Rosario Notaro
View Articletitled, Highly homologous T-cell receptor beta sequences support a common target for autoreactive T cells in most patients with paroxysmal nocturnal hemoglobinuria

STEM CELLS IN HEMATOLOGY

Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells
Michelle B. Bowie,David G. Kent,Michael R. Copley,Connie J. Eaves
View Articletitled, Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells

TRANSPLANTATION

Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD
Kelli P. A. MacDonald,Rachel D. Kuns,Vanessa Rowe,Edward S. Morris,Tatjana Banovic,Helen Bofinger,Brendan O'Sullivan,Kate A. Markey,Alistair L. Don,Ranjeny Thomas,Geoffrey R. Hill
View Articletitled, Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD
Supplemental data
Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT
Brief Report
Jeffery S. Miller,Sarah Cooley,Peter Parham,Sherif S. Farag,Michael R. Verneris,Karina L. McQueen,Lisbeth A. Guethlein,Elizabeth A. Trachtenberg,Michael Haagenson,Mary M. Horowitz,John P. Klein,Daniel J. Weisdorf
View Articletitled, Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT

CORRESPONDENCE

Isolated high-molecular-weight kininogen deficiency: a novel frameshift mutation in exon 10
Toshio Shigekiyo,Junko Miyagi,Atsuhisa Shirakami,Hironobu Shibata,Kazuo Tsukai,Ken-ichi Aihara
View Articletitled, Isolated high-molecular-weight kininogen deficiency: a novel frameshift mutation in exon 10
Donor lymphocyte infusions for the treatment of minimal residual disease in acute leukemia
Alida Dominietto,Sarah Pozzi,Maurizio Miglino,Flavio Albarracin,Giovanna Piaggio,Francesca Bertolotti,Raffaella Grasso,Simona Zupo,Anna Maria Raiola,Marco Gobbi,Francesco Frassoni,Andrea Bacigalupo
View Articletitled, Donor lymphocyte infusions for the treatment of minimal residual disease in acute leukemia
Killer cell Ig-like receptors CD158a and CD158b display a coactivatory function, involving the c-Jun NH2-terminal protein kinase signaling pathway, when expressed on malignant CD4+ T cells from a patient with Sézary syndrome
Anne Marie-Cardine,Delphine Huet,Nicolas Ortonne,Natacha Remtoula,Sabine Le Gouvello,Martine Bagot,Armand Bensussan
View Articletitled, Killer cell Ig-like receptors CD158a and CD158b display a coactivatory function, involving the c-Jun NH<sub>2</sub>-terminal protein kinase signaling pathway, when expressed on malignant CD4<sup>+</sup> T cells from a patient with Sézary syndrome
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